Abstract:
:Matrix metalloproteinases (MMPs) and tissue inhibitors of matrix metalloproteinases (TIMPs) are thought to be associated with coronary artery disease. The association of these markers with incident coronary artery disease has not been well described. Using a case-cohort design, we selected 216 individuals who had incident coronary artery disease (case group) and 225 individuals from a cohort random sample (comparison group) from participants enrolled in the Atherosclerosis Risk in Communities study. We measured plasma levels of MMP-1 and TIMP-1, traditional risk factors, and other markers of inflammation. We found no significant difference in TIMP-1 levels between the case group (827.8 +/- 23.8 ng/mL) and the comparison group (819.31 +/- 16.1 ng/mL) (P=0.77), and no significant difference in the frequency of MMP-1 levels that were dichotomized at the minimum detectable value of 1.7 ng/mL (P=0.49). In models adjusted for age, sex, race, body mass index, hypertension, diabetes, total cholesterol, high-density lipoprotein cholesterol, triglycerides, fibrinogen, von Willebrand factor, and white blood cell count, the hazard-rate ratio for incident coronary artery disease was 1.14 (95% confidence interval, 0.63-2.04; P=0.67) for individuals whose TIMP-1 levels were above, versus at or below the mean, and 1.17 (95% confidence interval, 0.63-2.19; P=0.62) for individuals whose MMP-1 levels were above 1.7 ng/mL. We conclude that TIMP-1 and MMP-1 levels in plasma were not predictive of incident coronary artery disease in a case-cohort random sample of the Atherosclerosis Risk in Communities study, a population study of asymptomatic middle-aged adults who had no prevalent atherosclerosis upon enrollment.
journal_name
Tex Heart Inst Jjournal_title
Texas Heart Institute journalauthors
Nambi V,Morrison AC,Hoogeveen RC,Coresh J,Miles S,Rhodes CE,Sharrett AR,Boerwinkle BE,Ballantyne CMsubject
Has Abstractpub_date
2008-01-01 00:00:00pages
388-94issue
4eissn
0730-2347issn
1526-6702journal_volume
35pub_type
杂志文章abstract::Aortoventricular fistula, a rare congenital or acquired defect of the aortic wall, is characterized by an abnormal connection between the aorta and one of the ventricles. Symptom severity correlates with the diameter of the fistula and with the acute or chronic timing of presentation. The diagnosis is usually made by ...
journal_title:Texas Heart Institute journal
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doi:10.14503/THIJ-17-6332
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journal_title:Texas Heart Institute journal
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journal_title:Texas Heart Institute journal
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journal_title:Texas Heart Institute journal
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journal_title:Texas Heart Institute journal
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journal_title:Texas Heart Institute journal
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更新日期:2004-01-01 00:00:00
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journal_title:Texas Heart Institute journal
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journal_title:Texas Heart Institute journal
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journal_title:Texas Heart Institute journal
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journal_title:Texas Heart Institute journal
pub_type: 杂志文章
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journal_title:Texas Heart Institute journal
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doi:
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pub_type: 杂志文章
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journal_title:Texas Heart Institute journal
pub_type: 杂志文章,评审
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更新日期:2012-01-01 00:00:00
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journal_title:Texas Heart Institute journal
pub_type: 杂志文章
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journal_title:Texas Heart Institute journal
pub_type: 杂志文章
doi:
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journal_title:Texas Heart Institute journal
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更新日期:2008-01-01 00:00:00
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pub_type: 杂志文章,多中心研究
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journal_title:Texas Heart Institute journal
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