Matrix metalloproteinase-1 and tissue inhibitors do not predict incident coronary artery disease in the atherosclerosis risk in communities (ARIC) study.

Abstract:

:Matrix metalloproteinases (MMPs) and tissue inhibitors of matrix metalloproteinases (TIMPs) are thought to be associated with coronary artery disease. The association of these markers with incident coronary artery disease has not been well described. Using a case-cohort design, we selected 216 individuals who had incident coronary artery disease (case group) and 225 individuals from a cohort random sample (comparison group) from participants enrolled in the Atherosclerosis Risk in Communities study. We measured plasma levels of MMP-1 and TIMP-1, traditional risk factors, and other markers of inflammation. We found no significant difference in TIMP-1 levels between the case group (827.8 +/- 23.8 ng/mL) and the comparison group (819.31 +/- 16.1 ng/mL) (P=0.77), and no significant difference in the frequency of MMP-1 levels that were dichotomized at the minimum detectable value of 1.7 ng/mL (P=0.49). In models adjusted for age, sex, race, body mass index, hypertension, diabetes, total cholesterol, high-density lipoprotein cholesterol, triglycerides, fibrinogen, von Willebrand factor, and white blood cell count, the hazard-rate ratio for incident coronary artery disease was 1.14 (95% confidence interval, 0.63-2.04; P=0.67) for individuals whose TIMP-1 levels were above, versus at or below the mean, and 1.17 (95% confidence interval, 0.63-2.19; P=0.62) for individuals whose MMP-1 levels were above 1.7 ng/mL. We conclude that TIMP-1 and MMP-1 levels in plasma were not predictive of incident coronary artery disease in a case-cohort random sample of the Atherosclerosis Risk in Communities study, a population study of asymptomatic middle-aged adults who had no prevalent atherosclerosis upon enrollment.

journal_name

Tex Heart Inst J

authors

Nambi V,Morrison AC,Hoogeveen RC,Coresh J,Miles S,Rhodes CE,Sharrett AR,Boerwinkle BE,Ballantyne CM

subject

Has Abstract

pub_date

2008-01-01 00:00:00

pages

388-94

issue

4

eissn

0730-2347

issn

1526-6702

journal_volume

35

pub_type

杂志文章
  • Contemporary treatment of unstable angina and non-ST-segment-elevation myocardial infarction (part 2).

    abstract::In Part 1 of this review, we discussed how plaque rupture is the most common underlying cause of most cases of unstable angina/non-ST-segment-elevation myocardial infarction (UA/NSTEMI) and how early risk stratification is vital for the timely diagnosis and treatment of acute coronary syndromes (ACS). Now, in Part 2, ...

    journal_title:Texas Heart Institute journal

    pub_type: 杂志文章,评审

    doi:

    authors: Sami S,Willerson JT

    更新日期:2010-01-01 00:00:00

  • Resolution of right-sided heart failure symptoms after resection of a primary ovarian carcinoid tumor.

    abstract::Carcinoid tumors are rare neuroendocrine malignancies that typically originate from the gastrointestinal tract. Patients who are diagnosed with carcinoid heart disease generally have poor prognoses because of advanced metastases during staging and few therapeutic options. We present the case of a 61-year-old woman wit...

    journal_title:Texas Heart Institute journal

    pub_type: 杂志文章

    doi:10.14503/THIJ-13-3314

    authors: Goldman T,Adamson K,Yang E

    更新日期:2014-10-01 00:00:00

  • Safety and Outcomes of Transcatheter Closure of Patent Ductus Arteriosus in Children With Pulmonary Artery Hypertension.

    abstract::To investigate whether transcatheter device closure of patent ductus arteriosus (PDA) is safe in children with pulmonary artery hypertension, we retrospectively analyzed our experience with 33 patients who underwent the procedure from January 2000 through August 2015. Pulmonary artery hypertension was defined as a pul...

    journal_title:Texas Heart Institute journal

    pub_type: 杂志文章

    doi:10.14503/THIJ-19-6982

    authors: Salavitabar A,Krishnan US,Turner ME,Vincent JA,Torres AJ,Crystal MA

    更新日期:2020-08-01 00:00:00

  • Stent implantation in an adult with coarctation of the aorta in the presence of advanced secondary heart failure.

    abstract::We report the case of a 56-year-old woman with congenital coarctation of the aorta, who presented in critical clinical condition with advanced secondary cardiomyopathy and heart failure. We successfully applied an unusual technique to pass the aortic obstruction, and then implanted a PALMAZ stent. The procedure result...

    journal_title:Texas Heart Institute journal

    pub_type: 杂志文章

    doi:

    authors: Alcibar J,Peña N,Oñate A,Gochi R,Barrenechea JI

    更新日期:1999-01-01 00:00:00

  • The prevention of cardiovascular disease in cancer survivors.

    abstract::The number of cancer survivors in the United States has exceeded 12 million and is increasing. After secondary malignancies, cardiovascular disease is the leading cause of late morbidity and death among cancer survivors. The cardiovascular needs of cancer survivors have not been described. We describe the clinical cha...

    journal_title:Texas Heart Institute journal

    pub_type: 杂志文章

    doi:

    authors: Daher IN,Daigle TR,Bhatia N,Durand JB

    更新日期:2012-01-01 00:00:00

  • Progressive visual deterioration leading to blindness after pediatric heart transplantation.

    abstract::We present the case of a 10-year-old girl who developed visual loss progressing to blindness after orthotopic heart transplantation and an immunosuppressive regimen of cyclosporine, azathioprine, and prednisone. Headaches and visual deterioration began 2 months after transplantation, and a diagnosis of pseudotumor cer...

    journal_title:Texas Heart Institute journal

    pub_type: 杂志文章

    doi:

    authors: Schowengerdt KO Jr,Gajarski RJ,Denfield S

    更新日期:1993-01-01 00:00:00

  • Hypertrophic obstructive cardiomyopathy in combination with anomalous insertion of papillary muscle directly into anterior mitral leaflet and "sawfish" systolic narrowing of the left anterior descending coronary artery.

    abstract::This report describes an unusual case of subaortic stenosis in which hypertrophic obstructive cardiomyopathy was found in combination with both anomalous insertion of papillary muscle directly into the anterior mitral leaflet and "sawfish" systolic narrowing of the left anterior descending coronary artery. Definitive ...

    journal_title:Texas Heart Institute journal

    pub_type: 杂志文章

    doi:

    authors: Taşdemir O,Küçükaksu DS,Kural T,Bayazit K

    更新日期:1994-01-01 00:00:00

  • Superior vena cava thrombosis and paradoxical embolic stroke due to collateral drainage from the brachiocephalic vein to the left atrium.

    abstract::Thrombosis involving a permanent infusion catheter in the subclavian vein and superior vena cava is relatively common, especially in cancer patients. Edema of the arms and head is a well-known clinical consequence of this thrombosis, with an intrinsic risk of pulmonary embolism; however, systemic embolization into the...

    journal_title:Texas Heart Institute journal

    pub_type: 杂志文章

    doi:

    authors: Nascimbene A,Angelini P

    更新日期:2011-01-01 00:00:00

  • Repair of postinfarction ventricular septal rupture with a tailored, 3-dimensional patch.

    abstract::We modified the technique of patch repair for postinfarction ventricular septal rupture by beginning with a larger-than-needed circular patch and later trimming it into a 3-dimensional patch to match the size of the exclusion area. This technique makes it easier to determine the optimal size for the patch, and the com...

    journal_title:Texas Heart Institute journal

    pub_type: 杂志文章

    doi:

    authors: Fujiwara H,Sugano T,Someya T

    更新日期:2004-01-01 00:00:00

  • Rapid development of coronary arterial stenosis following valve replacement: an unusual cause of myocardial ischemia.

    abstract::A 56-year-old woman had unstable angina pectoris 3 months after aortic and mitral valve replacement for rheumatic heart disease. Repeat coronary arteriography revealed critical proximal left anterior descending and circumflex artery stenoses in previously normal coronary arteries. This case emphasizes the need for tho...

    journal_title:Texas Heart Institute journal

    pub_type: 杂志文章

    doi:

    authors: Graf R,Verani MS

    更新日期:1986-09-01 00:00:00

  • 19-year patency of a coronary-coronary venous bypass graft.

    abstract::No data are available on the long-term outcome of coronary-coronary venous bypass grafting. We describe a case in which we successfully stented a discrete, critical stenosis of a coronary-coronary venous graft that had been placed 19 years earlier to minimize manipulation of a severely calcified ascending aorta. Coron...

    journal_title:Texas Heart Institute journal

    pub_type: 杂志文章

    doi:

    authors: Mariscalco G,Blanzola C,Leva C,Bruno VD,Luvini M,Sala A

    更新日期:2005-01-01 00:00:00

  • Myocardial protection in diffuse coronary artery disease. Intermittent retrograde cold-blood cardioplegia at systemic normothermia versus intermittent antegrade cold-blood cardioplegia at moderate systemic hypothermia.

    abstract::In order to determine the comparative merits of antegrade cardioplegia at moderate systemic hypothermia versus retrograde cardioplegia at systemic normothermia, we performed coronary artery bypass grafting using intermittent oxygenated blood cardioplegia in 2 sets of 50 consecutive patients with triple-vessel disease ...

    journal_title:Texas Heart Institute journal

    pub_type: 杂志文章

    doi:

    authors: Hoffman D,Fernandes S,Frater RW,Sisto D

    更新日期:1993-01-01 00:00:00

  • Left stellate ganglion block for continuous ventricular arrhythmias during percutaneous left ventricular assist device support.

    abstract::A 58-year-old man presented with chest pain and tightness and was diagnosed with a Q-wave anterior myocardial infarction. He then developed pulseless ventricular arrhythmias, which were treated with repeated direct-current shocks and intravenous amiodarone. He underwent emergency cardiac catheterization: stents were d...

    journal_title:Texas Heart Institute journal

    pub_type: 杂志文章

    doi:

    authors: Loyalka P,Hariharan R,Gholkar G,Gregoric ID,Tamerisa R,Nathan S,Kar B

    更新日期:2011-01-01 00:00:00

  • Total arterial coronary bypass: long-term results.

    abstract::Three groups of consecutive patients who had undergone primary elective coronary artery bypass operations were compared at 10 to 20 years of follow-up (mean, 13.6 years), in order to test the supposition that arterial conduits provide better long-term outcome than do the "standard" left internal mammary-to-left anteri...

    journal_title:Texas Heart Institute journal

    pub_type: 杂志文章

    doi:

    authors: Korompai FL,Knight WL

    更新日期:2005-01-01 00:00:00

  • High-Grade Atrioventricular Block Associated With Acute Influenza.

    abstract::Influenza causes cardiac and pulmonary complications that can lead to death. Its effect on the conduction system, first described a century ago, has long been thought to be fairly benign. We report 2 cases of high-grade atrioventricular block associated with acute influenza infection. Both patients-a 50-year-old woman...

    journal_title:Texas Heart Institute journal

    pub_type: 杂志文章

    doi:10.14503/THIJ-18-6658

    authors: Ergle K,Gooden JY,Ahmed MM

    更新日期:2020-06-01 00:00:00

  • Chest pain and angiographically normal coronary arteries. Implications for treatment.

    abstract::Approximately 20% to 30% of patients who undergo coronary arteriography for the evaluation of chest pain are found to have normal coronary arteries. These patients have a survival rate comparable to that of the normal population, yet they continue to complain of symptoms on extended follow-up, and about half of this g...

    journal_title:Texas Heart Institute journal

    pub_type: 杂志文章,评审

    doi:

    authors: Mukerji V,Beitman BD,Alpert MA

    更新日期:1993-01-01 00:00:00

  • Structural failure of a Starr-Edwards aortic track valve.

    abstract::Structural failure of a Model 2400 Starr-Edwards aortic track valve occurred suddenly, 4 years after implantation. At operation, the valve cage was removed from the descending aorta. Examination of the excised prosthesis disclosed minimal cloth wear and no evidence of infective growth; however, three struts were fract...

    journal_title:Texas Heart Institute journal

    pub_type: 杂志文章

    doi:

    authors: Ringel RE,Moulton AL,Burns JE,Brenner JI,Berman MA

    更新日期:1983-03-01 00:00:00

  • Bronchogenic cyst.

    abstract::The clinical presentation of the bronchogenic cyst is variable, from respiratory distress at birth to late appearance of symptoms. In order to determine clinical features and treatments, we retrospectively studied the medical records and pathology reports of all patients with bronchogenic cysts (n = 22) referred to ou...

    journal_title:Texas Heart Institute journal

    pub_type: 杂志文章

    doi:

    authors: Sarper A,Ayten A,Golbasi I,Demircan A,Isin E

    更新日期:2003-01-01 00:00:00

  • Magnetic resonance imaging of myocardial fibrosis in hypertrophic cardiomyopathy.

    abstract::Myocardial fibrosis can occur in patients who have hypertrophic cardiomyopathy in the absence of epicardial coronary disease. In such patients, myocardial fibrosis has been linked to a poorer prognosis than in those without fibrosis. Gadolinium-DTPA delayed-enhancement magnetic resonance imaging (de-MRI) accurately id...

    journal_title:Texas Heart Institute journal

    pub_type: 杂志文章

    doi:

    authors: Wilson JM,Villareal RP,Hariharan R,Massumi A,Muthupillai R,Flamm SD

    更新日期:2002-01-01 00:00:00

  • Severe spinal cord ischemic injury secondary to device embolization after transcatheter closure of a patent arterial duct.

    abstract::Percutaneous closure of patent arterial ducts with the Amplatzer Ductal Occluder has become an effective and widely accepted alternative to surgical management. Although rarely, the occluder can be dislodged after an initially successful deployment, and with catastrophic consequences. We describe such a case in a 12-m...

    journal_title:Texas Heart Institute journal

    pub_type: 杂志文章,评审

    doi:10.14503/THIJ-12-2927

    authors: Tang L,Zhou S,Shen X

    更新日期:2014-02-01 00:00:00

  • Embolization of a complete prosthetic aortic valve to the abdominal aorta. Long-term survival after surgery.

    abstract::We describe a case of complete embolization of an aortic valve prosthesis to the abdominal aorta. To our knowledge, this patient is the 1st asymptomatic long-term survivor of this catastrophic event. In such cases, we recommend emergency surgery on the basis of echocardiographic results alone. Delay for more complete ...

    journal_title:Texas Heart Institute journal

    pub_type: 杂志文章

    doi:

    authors: Villani M,Leotta E,Cesarani F,Isolato G

    更新日期:1996-01-01 00:00:00

  • Successful outcome following a disrupted Björk-Shiley prosthetic mitral valve.

    abstract::This report describes an early diagnosis and successful correction of a disrupted "improved" Björk-Shiley prosthetic valve in the mitral position. The role of 2-Dimensional echocardiography in the diagnosis is emphasized. ...

    journal_title:Texas Heart Institute journal

    pub_type: 杂志文章

    doi:

    authors: Patel RR,Senan P,Nair M,Ramesh ML,Ticzon AR

    更新日期:1985-03-01 00:00:00

  • Rapid Extracorporeal Membrane Oxygenation Overcomes Fulminant Myocarditis Induced by 5‑Fluorouracil.

    abstract::Fulminant myocarditis is a rare but potentially life-threatening illness caused by 5-fluorouracil cardiotoxicity. Data supporting the use of extracorporeal membrane oxygenation for the treatment of fulminant myocarditis are limited. A 49-year-old, previously healthy white man, recently diagnosed with anal squamous cel...

    journal_title:Texas Heart Institute journal

    pub_type: 杂志文章

    doi:10.14503/THIJ-15-5100

    authors: Amraotkar AR,Pachika A,Grubb KJ,DeFilippis AP

    更新日期:2016-04-01 00:00:00

  • Ventricular arrhythmias in congestive heart failure: clinical significance and management.

    abstract::The benefit of defibrillator therapy has been well established for patients with LV dysfunction (ejection fraction less than 35%), coronary artery disease, NSVT, and inducible and nonsuppressible ventricular tachycardia. Implantable cardioverter-defibrillator therapy is also indicated for all CHF patients in NYHA func...

    journal_title:Texas Heart Institute journal

    pub_type: 杂志文章,评审

    doi:

    authors: Khoshnevis GR,Massumi A

    更新日期:1999-01-01 00:00:00

  • Remission of chronic, advanced heart failure after left ventricular unloading with an implantable left ventricular assist device.

    abstract::We describe the case of a 35-year-old man with severe, dilated idiopathic cardiomyopathy who was placed on the waiting list for cardiac transplantation. While awaiting transplantation, his heart failure decompensated to such a degree that left ventricular assist device support was necessary. He did well on device supp...

    journal_title:Texas Heart Institute journal

    pub_type: 杂志文章

    doi:

    authors: Demirozu ZT,Frazier OH

    更新日期:2012-01-01 00:00:00

  • Suspected Legionella-induced perimyocarditis in an adult in the absence of pneumonia: a rare clinical entity.

    abstract::Legionella infection can manifest itself in many clinical forms, most commonly as pneumonia, but rarely in the form of myocardial involvement. Legionella with myocardial involvement independent of pneumonia is almost never seen in the adult population and therefore is cited only a handful of times in the medical liter...

    journal_title:Texas Heart Institute journal

    pub_type: 杂志文章

    doi:

    authors: Burke PT,Shah R,Thabolingam R,Saba S

    更新日期:2009-01-01 00:00:00

  • Going around the bend: deep inspiration facilitates difficult stent delivery in the native coronary arteries.

    abstract::Percutaneous coronary intervention in tortuous or calcified vessels poses a substantial challenge for interventional cardiologists. Many techniques have been described to overcome the challenge, including the use of stiffer wires, buddy wires, the anchor balloon technique, and deep seating of the guide catheter. Herei...

    journal_title:Texas Heart Institute journal

    pub_type: 杂志文章

    doi:

    authors: Attaran RR,Butman S,Movahed MR

    更新日期:2011-01-01 00:00:00

  • Myocardial dysplasia in a 3rd-trimester fetus. An ultrasound and pathologic study.

    abstract::Arrested myocardial development, often described as spongiosum heart, has been reported in association with obstructive semilunar valve disease and, much more rarely, as a primary disease in adolescents and adults. To our knowledge, this condition has never been diagnosed in utero. We describe the echocardiographic an...

    journal_title:Texas Heart Institute journal

    pub_type: 杂志文章

    doi:

    authors: Paladini D,Russo M,Palmieri S,Pacileo G,Caruso G,Ianniruberto A,Martinelli P,Calabrò R

    更新日期:1997-01-01 00:00:00

  • Lambl's excrescences: review and recommendations.

    abstract::Lambl's excrescences are filiform fronds that occur at sites of valve closure. They originate as small thrombi on endocardial surfaces (where the valve margins contact) and have the potential to embolize to distant organs. We describe the case of a 61-year-old woman who presented with repeated episodes of stroke. She ...

    journal_title:Texas Heart Institute journal

    pub_type: 杂志文章,评审

    doi:

    authors: Aziz F,Baciewicz FA Jr

    更新日期:2007-01-01 00:00:00

  • Recurrent Biatrial Myxoma in a 41-Year-Old Woman after Left Atrial Myxoma Resection.

    abstract::Bilateral recurrence of atrial myxoma has been reported only a few times. We describe the case of a 41-year-old woman who had undergone left atrial myxoma resection and presented 9 years later with myxomas in both atria. The patient underwent successful resection of both masses with resolution of symptoms. We discuss ...

    journal_title:Texas Heart Institute journal

    pub_type: 杂志文章

    doi:10.14503/THIJ-16-6017

    authors: Jia X,Kohli A,Jarjour J,Chen CJ,Gilmore B,Tabbaa R,Poythress EL

    更新日期:2017-12-19 00:00:00