Abstract:
:Cellular hypoxia is a fundamental mechanism of injury in the critically ill. The study of human responses to hypoxia occurring as a consequence of hypobaria defines the fields of high-altitude medicine and physiology. A new paradigm suggests that the physiological and pathophysiological responses to extreme environmental challenges (for example, hypobaric hypoxia, hyperbaria, microgravity, cold, heat) may be similar to responses seen in critical illness. The present review explores the idea that human responses to the hypoxia of high altitude may be used as a means of exploring elements of the pathophysiology of critical illness.
journal_name
Crit Carejournal_title
Critical care (London, England)authors
Grocott M,Montgomery H,Vercueil Adoi
10.1186/cc5142subject
Has Abstractpub_date
2007-01-01 00:00:00pages
203issue
1eissn
1364-8535issn
1466-609Xpii
cc5142journal_volume
11pub_type
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