Abstract:
:Abnormalities in EEG gamma band oscillations (GBO, 30-80 Hz) serve as a prominent biomarker of schizophrenia (Sz), associated with positive, negative, and cognitive symptoms. Chronic, subanesthetic administration of antagonists of N-methyl-D-aspartate receptors (NMDAR), such as ketamine, elicits behavioral effects, and alterations in cortical interneurons similar to those observed in Sz. However, the chronic effects of ketamine on neocortical GBO are unknown. Thus, here we examine the effects of chronic (five daily i.p. injections) application of ketamine (5 and 30 mg/kg) and the more specific NMDAR antagonist, MK-801 (0.02, 0.5, and 2 mg/kg), on neocortical GBO ex vivo. Oscillations were generated by focal application of the glutamate receptor agonist, kainate (KA), in coronal brain slices containing the prelimbic cortex. This region constitutes the rodent analog of the human dorsolateral prefrontal cortex, a brain region strongly implicated in Sz-pathophysiology. Here we report the novel finding that chronic ketamine elicits a reduction in the peak oscillatory frequency of KA-elicited oscillations (from 47 to 40 Hz at 30 mg/kg). Moreover, the power of GBO in the 40-50 Hz band was reduced. These findings are reminiscent of both the reduced resonance frequency and power of cortical oscillations observed in Sz clinical studies. Surprisingly, MK-801 had no significant effect, suggesting care is needed when equating Sz-like behavioral effects elicited by different NMDAR antagonists to alterations in GBO activity. We conclude that chronic ketamine in the mouse mimics GBO abnormalities observed in Sz patients. Use of this ex vivo slice model may be useful in testing therapeutic compounds which rescue these GBO abnormalities.
journal_name
Front Psychiatryjournal_title
Frontiers in psychiatryauthors
McNally JM,McCarley RW,Brown REdoi
10.3389/fpsyt.2013.00106subject
Has Abstractpub_date
2013-09-17 00:00:00pages
106issn
1664-0640journal_volume
4pub_type
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journal_title:Frontiers in psychiatry
pub_type: 杂志文章
doi:10.3389/fpsyt.2011.00010
更新日期:2011-03-17 00:00:00
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journal_title:Frontiers in psychiatry
pub_type: 杂志文章
doi:10.3389/fpsyt.2018.00145
更新日期:2018-04-19 00:00:00
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journal_title:Frontiers in psychiatry
pub_type: 杂志文章
doi:10.3389/fpsyt.2018.00486
更新日期:2018-10-08 00:00:00
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pub_type: 杂志文章
doi:10.3389/fpsyt.2020.602315
更新日期:2020-12-07 00:00:00
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journal_title:Frontiers in psychiatry
pub_type: 杂志文章,评审
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pub_type: 杂志文章
doi:10.3389/fpsyt.2020.533784
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pub_type: 杂志文章
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pub_type: 杂志文章,评审
doi:10.3389/fpsyt.2019.00494
更新日期:2019-07-12 00:00:00
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journal_title:Frontiers in psychiatry
pub_type: 杂志文章
doi:10.3389/fpsyt.2013.00149
更新日期:2013-11-15 00:00:00
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journal_title:Frontiers in psychiatry
pub_type: 杂志文章
doi:10.3389/fpsyt.2018.00123
更新日期:2018-04-18 00:00:00
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journal_title:Frontiers in psychiatry
pub_type: 杂志文章
doi:10.3389/fpsyt.2020.00725
更新日期:2020-07-29 00:00:00
abstract::Background: Catatonia is a syndrome comprising psychomotor, behavioral, and autonomous symptoms which may occur in the context of severe schizophrenic, affective, and other mental disorders or medical conditions. Treatment options include high dose benzodiazepines (lorazepam) and electroconvulsive therapy (ECT) with s...
journal_title:Frontiers in psychiatry
pub_type: 杂志文章
doi:10.3389/fpsyt.2019.00086
更新日期:2019-02-27 00:00:00
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journal_title:Frontiers in psychiatry
pub_type: 杂志文章
doi:10.3389/fpsyt.2020.572583
更新日期:2020-11-24 00:00:00
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journal_title:Frontiers in psychiatry
pub_type: 杂志文章,评审
doi:10.3389/fpsyt.2018.00567
更新日期:2018-11-06 00:00:00
abstract::Introduction: Clozapine is the most effective antipsychotic used for treatment resistant schizophrenia and recurrent suicidal behavior in schizophrenia or schizoaffective disorder. However, it has been underutilized due to its adverse reaction profile. Although clozapine is typically associated with neutropenia leadin...
journal_title:Frontiers in psychiatry
pub_type:
doi:10.3389/fpsyt.2020.572102
更新日期:2020-10-14 00:00:00
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journal_title:Frontiers in psychiatry
pub_type: 杂志文章
doi:10.3389/fpsyt.2020.566196
更新日期:2020-11-13 00:00:00
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journal_title:Frontiers in psychiatry
pub_type: 杂志文章
doi:10.3389/fpsyt.2013.00098
更新日期:2013-09-05 00:00:00
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journal_title:Frontiers in psychiatry
pub_type: 杂志文章
doi:10.3389/fpsyt.2018.00381
更新日期:2018-08-21 00:00:00
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journal_title:Frontiers in psychiatry
pub_type: 杂志文章
doi:10.3389/fpsyt.2017.00242
更新日期:2017-11-20 00:00:00
abstract:Background:Past studies using the Bonn Scale for the Assessment of Basic Symptoms (hereafter, Bonn Scale) have shown that self-reported perceptual/cognitive disturbances reveal which persons have or will soon develop schizophrenia. Here, we focused specifically on the clinical value of self-reported visual perceptual a...
journal_title:Frontiers in psychiatry
pub_type: 杂志文章
doi:10.3389/fpsyt.2018.00069
更新日期:2018-03-12 00:00:00
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pub_type: 杂志文章
doi:10.3389/fpsyt.2020.00832
更新日期:2020-08-31 00:00:00
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journal_title:Frontiers in psychiatry
pub_type: 杂志文章
doi:10.3389/fpsyt.2020.567189
更新日期:2020-10-09 00:00:00
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journal_title:Frontiers in psychiatry
pub_type: 杂志文章
doi:10.3389/fpsyt.2020.586355
更新日期:2020-11-20 00:00:00
abstract:Background:High prevalence of mental disorders has been found among female prisoners in Western countries, however, little is known about the epidemiology of mental disorders in such populations in China. This study aims to investigate psychiatric morbidity and comorbidity among sentenced prisoners in a female prison i...
journal_title:Frontiers in psychiatry
pub_type: 杂志文章
doi:10.3389/fpsyt.2020.00271
更新日期:2020-04-14 00:00:00
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journal_title:Frontiers in psychiatry
pub_type: 杂志文章
doi:10.3389/fpsyt.2017.00234
更新日期:2017-11-13 00:00:00
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journal_title:Frontiers in psychiatry
pub_type: 杂志文章
doi:10.3389/fpsyt.2012.00067
更新日期:2012-07-05 00:00:00
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journal_title:Frontiers in psychiatry
pub_type: 杂志文章
doi:10.3389/fpsyt.2020.535624
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journal_title:Frontiers in psychiatry
pub_type: 杂志文章
doi:10.3389/fpsyt.2020.586114
更新日期:2020-12-03 00:00:00
abstract:Background:Patients with schizophrenia and individuals at ultra-high risk for psychosis (UHR) have been reported to exhibit impaired recognition of facial emotion expressions. This impairment has involved both inaccuracy and negative bias of facial emotion recognition. The present study aimed to investigate whether UHR...
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pub_type: 杂志文章
doi:10.3389/fpsyt.2020.00577
更新日期:2020-06-26 00:00:00
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journal_title:Frontiers in psychiatry
pub_type: 杂志文章
doi:10.3389/fpsyt.2019.00433
更新日期:2019-07-04 00:00:00