Neuronize: a tool for building realistic neuronal cell morphologies.

abstract：:Experimentalallergic encephalomyelitis (EAE) is an animal model for inflammatory demyelinating autoimmune disease, i.e., multiple sclerosis (MS). In the present study, we investigated the antineuroinflammatory/neuroprotective effects of C16, an ανβ3 integrin-binding peptide, and recombinant rat ciliary neurotrophic fa...

journal_title：Frontiers in neuroanatomy

authors： Fang M,He D,Zhang F,Hu Z,Yang J,Jiang H,Han S

更新日期：2013-12-30 00:00:00

abstract：:In the olfactory bulb (OB) a sophisticated neuronal network mediates the primary processing of sensory information and extensive investigations over the past decades have greatly improved our understanding of the morphology and neuronal organization of the OB. However, efforts have mostly been focused on the different...

journal_title：Frontiers in neuroanatomy

authors： Maier AM,Breer H,Strotmann J

更新日期：2017-12-18 00:00:00

abstract：:The anterior cingulate cortex (ACC), surrounding the genu of the corpus callosum, plays important roles in emotional processing and is functionally divided into the dorsal, perigenual, and subgenual subregions (dACC, pgACC, and sgACC, respectively). Previous studies have suggested that the pgACC and sgACC have distinc...

journal_title：Frontiers in neuroanatomy

authors： Sakata H,Kim Y,Nejime M,Konoike N,Miyachi S,Nakamura K

更新日期：2019-07-31 00:00:00

abstract：:Historically, the molecular and cellular mechanisms of cerebellar development were investigated through structural descriptions and studying spontaneous mutations in animal models and humans. Advances in experimental embryology, genetic engineering, and neuroimaging techniques render today the possibility to approach ...

journal_title：Frontiers in neuroanatomy

authors： Martinez S,Andreu A,Mecklenburg N,Echevarria D

更新日期：2013-06-26 00:00:00

abstract：:The thalamocingulate tract is a key component of the Papez circuit that connects the anterior thalamic nucleus (ATN) to the cingulum bundle. While the other white matter connections, consisting of the fornix, cingulum bundle and mammillothalamic tract, were well defined in Papez's original 1937 paper, the anatomy of t...

journal_title：Frontiers in neuroanatomy

authors： Weininger J,Roman E,Tierney P,Barry D,Gallagher H,Murphy P,Levins KJ,O'Keane V,O'Hanlon E,Roddy DW

更新日期：2019-02-18 00:00:00

abstract：:Accurate 3D reconstruction of neurons is vital for applications linking anatomy and physiology. Reconstructions are typically created using Neurolucida after biocytin histology (BH). An alternative inexpensive and fast method is to use freeware such as Neuromantic to reconstruct from fluorescence imaging (FI) stacks a...

journal_title：Frontiers in neuroanatomy

authors： Blackman AV,Grabuschnig S,Legenstein R,Sjöström PJ

更新日期：2014-07-11 00:00:00

abstract：:Pathways arising from the ventral tegmental area (VTA) release dopamine and other neurotransmitters during the expectation and achievement of reward, and are regarded as central links of the brain networks that create drive, pleasure, and addiction. While the global pattern of VTA projections is well-known, the actual...

journal_title：Frontiers in neuroanatomy

authors： Aransay A,Rodríguez-López C,García-Amado M,Clascá F,Prensa L

更新日期：2015-05-19 00:00:00

abstract：:Dendritic spines are key components of a variety of microcircuits and they represent the majority of postsynaptic targets of glutamatergic axon terminals in the brain. The present article will focus on the discovery of dendritic spines, which was possible thanks to the application of the Golgi technique to the study o...

journal_title：Frontiers in neuroanatomy

authors： DeFelipe J

更新日期：2015-03-05 00:00:00

abstract：:Carnivorans are a diverse group of mammals that includes carnivorous, omnivorous and herbivorous, domesticated and wild species, with a large range of brain sizes. Carnivory is one of several factors expected to be cognitively demanding for carnivorans due to a requirement to outsmart larger prey. On the other hand, l...

journal_title：Frontiers in neuroanatomy

authors： Jardim-Messeder D,Lambert K,Noctor S,Pestana FM,de Castro Leal ME,Bertelsen MF,Alagaili AN,Mohammad OB,Manger PR,Herculano-Houzel S

更新日期：2017-12-12 00:00:00

abstract：:Calcium stores in neurons are heterogeneous in compartmentalization and molecular composition. Danio rerio (zebrafish) is an animal model with a simply folded cerebellum similar in cellular organization to that of mammals. The aim of the study was to identify new endoplasmic reticulum (ER) calcium store markers in zeb...

journal_title：Frontiers in neuroanatomy

authors： Furlan S,Campione M,Murgia M,Mosole S,Argenton F,Volpe P,Nori A

更新日期：2020-04-21 00:00:00

abstract：:Expansion microscopy and light sheet imaging (ExLSM) provide a viable alternative to existing tissue clearing and large volume imaging approaches. The analysis of intact volumes of brain tissue presents a distinct challenge in neuroscience. Recent advances in tissue clearing and light sheet microscopy have re-addresse...

journal_title：Frontiers in neuroanatomy

authors： Düring DN,Rocha MD,Dittrich F,Gahr M,Hahnloser RHR

更新日期：2019-01-31 00:00:00

abstract：:Dopamine (DA) modulates the effects of amino acid neurotransmitters (AANs), including GABA and glutamate, in motor, visual, olfactory, and reward systems (Hnasko et al., 2010; Stuber et al., 2010; Hnasko and Edwards, 2012). The results suggest that DA may play a similar modulatory role in the auditory pathways. Previo...

journal_title：Frontiers in neuroanatomy

authors： Fyk-Kolodziej BE,Shimano T,Gafoor D,Mirza N,Griffith RD,Gong TW,Holt AG

更新日期：2015-07-22 00:00:00

abstract：:Imaging entire mouse brains at submicron resolution has historically been a challenging undertaking and largely confined to the province of dedicated atlasing initiatives. This has limited systematic investigations into important areas of neuroscience, such as neural circuits, brain mapping and neurodegeneration. In t...

journal_title：Frontiers in neuroanatomy

authors： Amato SP,Pan F,Schwartz J,Ragan TM

更新日期：2016-03-22 00:00:00

abstract：:We evaluated the neuropil distribution of the enzymes NADPH diaphorase (NADPH-d) and cytochrome oxidase (CO) in the spinal cord of the agouti, a medium-sized diurnal rodent, together with the distribution pattern and morphometrical characteristics of NADPH-d reactive neurons across different spinal segments. Neuropil ...

journal_title：Frontiers in neuroanatomy

authors： Freire MA,Tourinho SC,Guimarães JS,Oliveira JL,Picanço-Diniz CW,Gomes-Leal W,Pereira A

更新日期：2008-05-26 00:00:00

abstract：:Immunohistochemistry (IHC) is a valuable method for identifying discrete neurochemical molecules by the interaction of target antigens with validated antibodies tagged with a visible label (e.g., peroxidase). We have developed an immunostaining method that is highly sensitive in detection of neurochemical antigens. Ou...

journal_title：Frontiers in neuroanatomy

authors： Goto S,Morigaki R,Okita S,Nagahiro S,Kaji R

更新日期：2015-03-03 00:00:00

abstract：:The hypothalamus has been a central topic in neuroanatomy because of its important physiological functions, but its mature organization remains elusive. Deciphering its embryonic and adult organization is crucial in an evolutionary approach of the organization of the vertebrate forebrain. Here we studied the molecular...

journal_title：Frontiers in neuroanatomy

authors： Santos-Durán GN,Menuet A,Lagadec R,Mayeur H,Ferreiro-Galve S,Mazan S,Rodríguez-Moldes I,Candal E

更新日期：2015-04-08 00:00:00

abstract：:Really interesting new gene (RING) finger protein is a type of zinc-binding motif found in a large family of functionally distinct proteins. RING finger proteins are involved in diverse cellular processes including apoptosis, DNA repair, cell cycle, signal transduction, tumour suppressor, vesicular transport, and pero...

journal_title：Frontiers in neuroanatomy

authors： Cham KL,Soga T,Parhar IS

更新日期：2017-08-31 00:00:00

abstract：:Involuntary movements or dyskinesia, represent a debilitating complication of levodopa therapy for Parkinson's disease. Dyskinesia is, ultimately, experienced by the vast majority of the patients. Despite the importance of this problem, little was known about the cause of dyskinesia, a situation that has dramatically ...

journal_title：Frontiers in neuroanatomy

authors： Barroso-Chinea P,Bezard E

更新日期：2010-09-14 00:00:00

abstract：:Previous developmental studies of the thalamus (alar part of the diencephalic prosomere p2) have defined the molecular basis for the acquisition of the thalamic competence (preparttening), the subsequent formation of the secondary organizer in the zona limitans intrathalamica, and the early specification of two antero...

journal_title：Frontiers in neuroanatomy

authors： Bandín S,Morona R,González A

更新日期：2015-08-10 00:00:00

abstract：:A60, the mouse monoclonal antibody against the neuronal nuclear protein (NeuN), is the most widely used neuronal marker in neuroscience research and neuropathological assays. Previous studies identified fragments of A60-immunoprecipitated protein as Synapsin I (Syn I), suggesting the antibody will demonstrate cross im...

journal_title：Frontiers in neuroanatomy

authors： Mao S,Xiong G,Zhang L,Dong H,Liu B,Cohen NA,Cohen AS

更新日期：2016-05-13 00:00:00

abstract：:Larger mammalian cerebral cortices tend to have increasingly folded surfaces, often considered to result from the lateral expansion of the gray matter (GM), which, in a volume constrained by the cranium, causes mechanical compression that is relieved by inward folding of the white matter (WM), or to result from differ...

journal_title：Frontiers in neuroanatomy

authors： Mota B,Herculano-Houzel S

更新日期：2012-02-02 00:00:00

abstract：:Expression patterns of Nkx2.1 and Islet-1 (Isl1), which encode transcription factors that are key in the regionalization of the forebrain, were analyzed by combined immunohistochemical methods in young adult specimens of two lungfishes (Neoceratodus forsteri and Protopterus dolloi) and a urodele amphibian (Pleurodeles...

journal_title：Frontiers in neuroanatomy

authors： Moreno N,López JM,Morona R,Lozano D,Jiménez S,González A

更新日期：2018-05-18 00:00:00

abstract：:Subsets of GABAergic neurons are able to maintain high frequency discharge patterns, which requires efficient replenishment of the releasable pool of GABA. Although glutamine is considered a preferred precursor of GABA, the identity of transporters involved in glutamine uptake by GABAergic neurons remains elusive. Mol...

journal_title：Frontiers in neuroanatomy

authors： Solbu TT,Bjørkmo M,Berghuis P,Harkany T,Chaudhry FA

更新日期：2010-02-08 00:00:00

abstract：:In rodents, sexual behavior depends on the adequate detection of sexually relevant stimuli. The olfactory bulb (OB) is a region of the adult mammalian brain undergoing constant cell renewal by continuous integration of new granular and periglomerular neurons in the accessory (AOB) and main (MOB) olfactory bulbs. The p...

journal_title：Frontiers in neuroanatomy

authors： Portillo W,Unda N,Camacho FJ,Sánchez M,Corona R,Arzate DM,Díaz NF,Paredes RG

更新日期：2012-07-06 00:00:00

abstract：:When does adult hippocampal neurogenesis begin? We describe the development of the neurogenic niche in the subgranular zone (SGZ) of the hippocampal dentate gyrus. We did so from the perspective of the situation in the adult. Ontogeny of the dentate gyrus is complex and results in an ectopic neurogenic niche that life...

journal_title：Frontiers in neuroanatomy

authors： Nicola Z,Fabel K,Kempermann G

更新日期：2015-05-07 00:00:00

abstract：:Non-invasive in vivo neuroimaging techniques provide a wide array of possibilities to study human brain function. A number of approaches are available that improve our understanding of the anatomical location of brain activation patterns, including the development of probabilistic conversion tools to register individu...

journal_title：Frontiers in neuroanatomy

authors： Alkemade A,Groot JM,Forstmann BU

更新日期：2018-12-05 00:00:00

abstract：:Gaucher's disease (GD) is the most prevalent lysosomal storage disorder. GD is caused by homozygous mutations of the GBA1 gene, which codes for beta-glucocerebrosidase (GCase). Although GD primarily affects peripheral tissues, the presence of neurological symptoms has been reported in several GD subtypes. GBA1 mutatio...

journal_title：Frontiers in neuroanatomy

authors： Franco R,Sánchez-Arias JA,Navarro G,Lanciego JL

更新日期：2018-06-28 00:00:00

abstract：:The artiodactyl brain has multiple levels of vascular pooling and the rostral epidural rete mirabile (RERM) at its base. The current study is the first of its kind to precisely demonstrate the arterial vasculature of the dromedary brain, utilizing a new casting method with colored latex and epoxy paint. In total, 35 f...

journal_title：Frontiers in neuroanatomy

authors： Al Aiyan A,Menon P,AlDarwich A,Almuhairi F,Alnuaimi S,Bulshawareb A,Qablan M,Shehab S

更新日期：2019-07-05 00:00:00

abstract：:Biological impacts of light beyond vision, i.e., non-visual functions of light, signify the need to better understand light detection (or photoreception) systems in vertebrates. Photopigments, which comprise light-absorbing chromophores bound to a variety of G-protein coupled receptor opsins, are responsible for visua...

journal_title：Frontiers in neuroanatomy

authors： Hang CY,Kitahashi T,Parhar IS

更新日期：2016-04-27 00:00:00

abstract：:The radial dimension expands during central nervous system development after the proliferative neuroepithelium is molecularly patterned. The process is associated with neurogenesis, radial glia scaffolding, and migration of immature neurons into the developing mantle stratum. Radial histogenetic units, defined as a de...

journal_title：Frontiers in neuroanatomy

authors： Garcia-Calero E,Puelles L

更新日期：2020-11-10 00:00:00