Abstract:
:Subsets of GABAergic neurons are able to maintain high frequency discharge patterns, which requires efficient replenishment of the releasable pool of GABA. Although glutamine is considered a preferred precursor of GABA, the identity of transporters involved in glutamine uptake by GABAergic neurons remains elusive. Molecular analyses revealed that SAT1 (Slc38a1) features system A characteristics with a preferential affinity for glutamine, and that SAT1 mRNA expression is associated with GABAergic neurons. By generating specific antibodies against SAT1 we show that this glutamine carrier is particularly enriched in GABAergic neurons. Cellular SAT1 distribution resembles that of GAD67, an essential GABA synthesis enzyme, suggesting that SAT1 can be involved in translocating glutamine into GABAergic neurons to facilitate inhibitory neurotransmitter generation.
journal_name
Front Neuroanatjournal_title
Frontiers in neuroanatomyauthors
Solbu TT,Bjørkmo M,Berghuis P,Harkany T,Chaudhry FAdoi
10.3389/neuro.05.001.2010subject
Has Abstractpub_date
2010-02-08 00:00:00pages
1issn
1662-5129journal_volume
4pub_type
杂志文章abstract::In rodents, sexual behavior depends on the adequate detection of sexually relevant stimuli. The olfactory bulb (OB) is a region of the adult mammalian brain undergoing constant cell renewal by continuous integration of new granular and periglomerular neurons in the accessory (AOB) and main (MOB) olfactory bulbs. The p...
journal_title:Frontiers in neuroanatomy
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journal_title:Frontiers in neuroanatomy
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journal_title:Frontiers in neuroanatomy
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journal_title:Frontiers in neuroanatomy
pub_type: 杂志文章,评审
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journal_title:Frontiers in neuroanatomy
pub_type: 杂志文章
doi:10.3389/fnana.2016.00092
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pub_type: 杂志文章
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journal_title:Frontiers in neuroanatomy
pub_type: 杂志文章
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journal_title:Frontiers in neuroanatomy
pub_type: 杂志文章
doi:10.3389/fnana.2018.00041
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journal_title:Frontiers in neuroanatomy
pub_type: 杂志文章
doi:10.3389/fnana.2018.00009
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journal_title:Frontiers in neuroanatomy
pub_type: 杂志文章
doi:10.3389/fnana.2014.00127
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journal_title:Frontiers in neuroanatomy
pub_type: 杂志文章,评审
doi:10.3389/fnana.2014.00077
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journal_title:Frontiers in neuroanatomy
pub_type: 杂志文章
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journal_title:Frontiers in neuroanatomy
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doi:10.3389/fnana.2017.00097
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journal_title:Frontiers in neuroanatomy
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journal_title:Frontiers in neuroanatomy
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journal_title:Frontiers in neuroanatomy
pub_type: 杂志文章
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journal_title:Frontiers in neuroanatomy
pub_type: 杂志文章,评审
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journal_title:Frontiers in neuroanatomy
pub_type: 杂志文章
doi:10.3389/fnana.2018.00052
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journal_title:Frontiers in neuroanatomy
pub_type: 杂志文章,评审
doi:10.3389/fnana.2015.00014
更新日期:2015-03-05 00:00:00
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journal_title:Frontiers in neuroanatomy
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