The Regulation of Immune Responses by DC Derived Type I IFN.

abstract：:Myalgic encephalomyelitis (ME) often also called chronic fatigue syndrome (ME/CFS) is a common, debilitating, disease of unknown origin. Although a subject of controversy and a considerable scientific literature, we think that a solid understanding of ME/CFS pathogenesis is emerging. In this study, we compiled recent ...

journal_title：Frontiers in immunology

authors： Blomberg J,Gottfries CG,Elfaitouri A,Rizwan M,Rosén A

更新日期：2018-02-15 00:00:00

abstract：:NOD-like receptors (NLRs) are a class of cytoplasmic pattern-recognition receptors. Although most NLRs play some role in immunity, their functions range from regulating antigen presentation (NLRC5, CIITA) to pathogen/damage sensing (NLRP1, NLRP3, NLRC1/2, NLRC4) to suppression or modulation of inflammation (NLRC3, NLR...

journal_title：Frontiers in immunology

authors： Lupfer C,Kanneganti TD

更新日期：2013-09-17 00:00:00

abstract：:Natural killer (NK) cells are potent cytotoxic effector cells for cancer therapy and potentially for severe viral infections. However, there are technical challenges to obtain sufficient numbers of functionally active NK cells from a patient's blood since they represent only 10% of the lymphocytes and are often dysfun...

journal_title：Frontiers in immunology

authors： Klingemann H,Boissel L,Toneguzzo F

更新日期：2016-03-14 00:00:00

abstract：:Tumor necrosis factor receptor-associated factor (TRAF) proteins are key signaling molecules that function in various cellular signaling events including immune response, cell death and survival, development, and thrombosis. Their roles in cellular signaling are mediated mostly by direct interactions with various rece...

journal_title：Frontiers in immunology

authors： Park HH

更新日期：2018-08-30 00:00:00

abstract：:Pertussis or whooping cough, mainly caused by Bordetella pertussis, is a severe respiratory disease that can affect all age groups but is most severe and can be life-threatening in young children. Vaccines against this disease are widely available since the 1950s. Despite high global vaccination coverage, the disease ...

journal_title：Frontiers in immunology

authors： Solans L,Locht C

更新日期：2019-01-14 00:00:00

abstract：:There is accumulating evidence to indicate that long non-coding RNAs (lncRNAs) are important regulators of the inflammatory response. In this report, we have employed next generation sequencing to identify 14 lncRNAs that are differentially expressed in human lung fibroblasts following the induction of inflammation us...

journal_title：Frontiers in immunology

authors： Hadjicharalambous MR,Roux BT,Feghali-Bostwick CA,Murray LA,Clarke DL,Lindsay MA

更新日期：2018-12-11 00:00:00

abstract：:Graft versus host disease (GVHD) is the major complication of allogeneic hematopoietic stem cell transplantation. GVHD is characterized by an imbalance between the effector and regulatory arms of the immune system which results in the over production of inflammatory cytokines. Moreover, there is a persistent reduction...

journal_title：Frontiers in immunology

authors： Beres AJ,Drobyski WR

更新日期：2013-06-24 00:00:00

abstract：Background:New sequencing techniques have revolutionized the identification of the molecular basis of primary immunodeficiency disorders (PID) not only by establishing a gene-based diagnosis but also by facilitating defect-specific treatment strategies, improving quality of life and survival, and allowing factual genet...

journal_title：Frontiers in immunology

authors： Segundo GRS,Nguyen ATV,Thuc HT,Nguyen LNQ,Kobayashi RH,Le HT,Le HTM,Torgerson TR,Ochs HD

更新日期：2018-02-16 00:00:00

abstract：:Endometriosis is an estrogen-dependent disease with symptoms of dysmenorrhea, chronic pain, and infertility that affects 6-10% of women of reproductive age. Medical or surgical therapy, such as administration of an anti-gonadotropin or ovarian cystectomy, provide effective pain relief. However, neither therapy can be ...

journal_title：Frontiers in immunology

authors： Kato T,Yasuda K,Matsushita K,Ishii KJ,Hirota S,Yoshimoto T,Shibahara H

更新日期：2019-08-22 00:00:00

abstract：:A wide variety of biomaterials have been developed as both stabilizing structures for the injured bone and inducers of bone neoformation. They differ in chemical composition, shape, porosity, and mechanical properties. The most extensively employed and studied subset of bioceramics are calcium phosphate materials (CaP...

journal_title：Frontiers in immunology

authors： Humbert P,Brennan MÁ,Davison N,Rosset P,Trichet V,Blanchard F,Layrolle P

更新日期：2019-04-02 00:00:00

abstract：:Adoptive cell transfer therapy is currently one of the most promising approaches for cancer treatment. This therapy has some limitations, however, such as the dispersion of in vivo-administered cells, causing only a small proportion to reach the tumor. Nanotechnological approaches could offer a solution for this drawb...

journal_title：Frontiers in immunology

authors： Sanz-Ortega L,Rojas JM,Portilla Y,Pérez-Yagüe S,Barber DF

更新日期：2019-08-30 00:00:00

abstract：:B7 proteins CD80 (B7-1) and CD86 (B7-2) are expressed on most antigen-presenting cells and provide critical co-stimulatory or inhibitory input to T cells via their T-cell-expressed receptors: CD28 and CTLA-4. CD28 is expressed on effector T cells and regulatory T cells (Tregs), and CD28-dependent signals are required ...

journal_title：Frontiers in immunology

authors： Brzostek J,Gascoigne NR,Rybakin V

更新日期：2016-02-04 00:00:00

abstract：Background:A plurality of neurological syndromes is associated with autoantibodies against neural antigens relevant for diagnosis and therapy. Identification of these antigens is crucial to understand the pathogenesis and to develop specific immunoassays. Using an indirect immunofluorescence assay (IFA)-based approach ...

journal_title：Frontiers in immunology

authors： Scharf M,Miske R,Kade S,Hahn S,Denno Y,Begemann N,Rochow N,Radzimski C,Brakopp S,Probst C,Teegen B,Stöcker W,Komorowski L

更新日期：2018-07-09 00:00:00

abstract：:Plasmacytoid dendritic cells (pDCs) are a specialized subset of DCs capable of rapidly producing copious amounts of type I IFN (IFN-I) in response to viral infections. The mechanism regulating rapid production of IFN-I after pDCs are exposed to viral nucleic acids remains elusive. Here, we show that the transcription ...

journal_title：Frontiers in immunology

authors： Ko YA,Chan YH,Liu CH,Liang JJ,Chuang TH,Hsueh YP,Lin YL,Lin KI

更新日期：2018-08-07 00:00:00

abstract：:Moraxella catarrhalis is a human-specific commensal of the respiratory tract and an opportunistic pathogen. It is one of the leading cause of otitis media in children and of acute exacerbations in patients with chronic obstructive pulmonary disease, resulting in significant morbidity and economic burden. Vaccines and ...

journal_title：Frontiers in immunology

authors： Laabei M,Colineau L,Bettoni S,Maziarz K,Ermert D,Riesbeck K,Ram S,Blom AM

更新日期：2020-09-02 00:00:00

abstract：:Microtubules play critical roles in regulating the activation of NLRP3 inflammasome and microtubule-destabilizing agents such as colchicine have been shown to suppress the activation of this inflammasome. However, it remains largely unknown whether paclitaxel, a microtubule-stabilizing agent being used in cancer thera...

journal_title：Frontiers in immunology

authors： Zeng QZ,Yang F,Li CG,Xu LH,He XH,Mai FY,Zeng CY,Zhang CC,Zha QB,Ouyang DY

更新日期：2019-01-29 00:00:00

abstract：:Although NGS technologies fuel advances in high-throughput HLA genotyping methods for identification and classification of HLA genes to assist with precision medicine efforts in disease and transplantation, the efficiency of these methods are impeded by the absence of adequately-characterized high-frequency HLA allele...

journal_title：Frontiers in immunology

authors： Suzuki S,Ranade S,Osaki K,Ito S,Shigenari A,Ohnuki Y,Oka A,Masuya A,Harting J,Baybayan P,Kitazume M,Sunaga J,Morishima S,Morishima Y,Inoko H,Kulski JK,Shiina T

更新日期：2018-10-04 00:00:00

abstract：:Although the role that Autoimmune Regulator (Aire) plays in the induction of central tolerance is well known, the precise cellular and molecular mechanisms are still unclear and debated. In the prevailing view, Aire serves mainly as a direct inducer of tissue-specific antigens. However, there is a growing amount of ev...

journal_title：Frontiers in immunology

authors： Laan M,Peterson P

更新日期：2013-10-11 00:00:00

abstract：:Primary immunodeficiencies (PIDs) are genetic disorders impairing host immunity, leading to life-threatening infections, autoimmunity, and/or malignancies. Genomic technologies have been critical for expediting the discovery of novel genetic defects underlying PIDs, expanding our knowledge of the complex clinical phen...

journal_title：Frontiers in immunology

authors： Seleman M,Hoyos-Bachiloglu R,Geha RS,Chou J

更新日期：2017-07-24 00:00:00

abstract：:HLA-E is a member of the non-classical HLA molecules and by interaction with activating or inhibitory receptors of NK and T cells, HLA-E can lead to immune activation or suppression context-dependently. Recently, the non-classical HLA molecules gain more attention in the setting of allogeneic hematopoietic stem cell t...

journal_title：Frontiers in immunology

authors： Kordelas L,Schwich E,Lindemann M,Heinemann FM,Buttkereit U,Horn PA,Beelen DW,Rebmann V

更新日期：2020-01-10 00:00:00

abstract：:Due to limited sepsis patient cohort size and extreme heterogeneity, only one significant locus and suggestive associations at several independent loci were implicated by three genome-wide association studies. However, genes from such suggestive loci may also provide crucial information to unravel genetic mechanisms t...

journal_title：Frontiers in immunology

authors： Le KTT,Matzaraki V,Netea MG,Wijmenga C,Moser J,Kumar V

更新日期：2019-08-14 00:00:00

abstract：:Despite advances, identification and formulation of safe and effective vaccine for long-lasting protection against leishmaniasis is still inadequate. In this study, we have identified a novel antigen, leishmanial elongation factor-1α (EF1-α), as an immunodominant component of solubilized leishmanial membrane antigens ...

journal_title：Frontiers in immunology

authors： Sabur A,Bhowmick S,Chhajer R,Ejazi SA,Didwania N,Asad M,Bhattacharyya A,Sinha U,Ali N

更新日期：2018-01-30 00:00:00

abstract：:Inflammation is a common characteristic of chronic liver disease (CLD). Inflammasomes are multiprotein complexes that can sense and recognize various exogenous and endogenous danger signals, eventually activating interleukin (IL)-1β and IL-18. The sensor component of the inflammasome system is a nucleotide-binding oli...

journal_title：Frontiers in immunology

authors： Wu X,Dong L,Lin X,Li J

更新日期：2017-12-12 00:00:00

abstract：:A systemic immune related response (SIME) of radiotherapy has been occasionally observed on metastatic tumors, but the clinical outcomes remain poor. Novel treatment approaches are therefore needed to improve SIME ratio. We used a combination of hypo-fractionated radiation therapy (H-RT) with low-dose total body irrad...

journal_title：Frontiers in immunology

authors： Liu J,Zhou J,Wu M,Hu C,Yang J,Li D,Wu P,Chen Y,Chen P,Lin S,Cui Y,Fu S,Wu J

更新日期：2019-02-27 00:00:00

abstract：:[This corrects the article DOI: 10.3389/fimmu.2019.01135.]. ...

journal_title：Frontiers in immunology

authors： Ramirez GA,Rovere-Querini P,Blasi M,Sartorelli S,Di Chio MC,Baldini M,De Lorenzo R,Bozzolo EP,Leone R,Mantovani A,Manfredi AA,Tombetti E

更新日期：2019-07-24 00:00:00

abstract：:Glycoproteins perform extra- and intracellular functions in innate and adaptive immunity by lectin-based interactions to exposed glyco-determinants. Herein, we document and mechanistically explain the formation of subcellular-specific N-glycosylation determinants on glycoproteins trafficking through the shared biosynt...

journal_title：Frontiers in immunology

authors： Lee LY,Lin CH,Fanayan S,Packer NH,Thaysen-Andersen M

更新日期：2014-08-25 00:00:00

abstract：:Studies in the recent years have advanced the knowledge of how host and parasite factors contribute to the pathogenesis of human tegumentary leishmaniasis. Polymorphism within populations of Leishmania from the same species has been documented; indicating that infection with different strains may lead to distinct clin...

journal_title：Frontiers in immunology

authors： Carvalho LP,Passos S,Schriefer A,Carvalho EM

更新日期：2012-10-04 00:00:00

abstract：:Background: Iron deficiency may impair adaptive immunity and is common among African infants at time of vaccination. Whether iron deficiency impairs vaccine response and whether iron supplementation improves humoral vaccine response is uncertain. Methods: We performed two studies in southern coastal Kenya. In a birth ...

journal_title：Frontiers in immunology

authors： Stoffel NU,Uyoga MA,Mutuku FM,Frost JN,Mwasi E,Paganini D,van der Klis FRM,Malhotra IJ,LaBeaud AD,Ricci C,Karanja S,Drakesmith H,King CH,Zimmermann MB

更新日期：2020-07-13 00:00:00

abstract：:Over the last decade, the acceleration in the clinical use of mesenchymal stromal cells (MSCs) has been nothing short of spectacular. Perhaps most surprising is how little we know about the "MSC product." Although MSCs are being delivered to patients at an alarming rate, the regulatory requirements for MSC therapies (...

journal_title：Frontiers in immunology

authors： Wilson A,Hodgson-Garms M,Frith JE,Genever P

更新日期：2019-05-16 00:00:00

abstract：:Defensins represents an integral part of the innate immune system serving to ward off potential pathogens and to protect the intestinal barrier from microbial encroachment. In addition to their antimicrobial activities, defensins in general, and human β-defensin 2 (hBD2) in particular, also exhibit immunomodulatory ca...

journal_title：Frontiers in immunology

authors： Koeninger L,Armbruster NS,Brinch KS,Kjaerulf S,Andersen B,Langnau C,Autenrieth SE,Schneidawind D,Stange EF,Malek NP,Nordkild P,Jensen BAH,Wehkamp J

更新日期：2020-01-31 00:00:00