Expression of infectious murine leukemia viruses by RAW264.7 cells, a potential complication for studies with a widely used mouse macrophage cell line.

abstract：BACKGROUND:Protein arginine methyltransferase 6 (PRMT6) is a nuclear enzyme that methylates arginine residues on histones and transcription factors. In addition, PRMT6 inhibits HIV-1 replication in cell culture by directly methylating and interfering with the functions of several HIV-1 proteins, i.e. Tat, Rev and nucle...

journal_title：Retrovirology

authors： Singhroy DN,Mesplède T,Sabbah A,Quashie PK,Falgueyret JP,Wainberg MA

更新日期：2013-07-17 00:00:00

abstract：BACKGROUND:One facet of the complexity underlying the biology of HIV-1 resides not only in its limited number of viral proteins, but in the extensive repertoire of cellular proteins they interact with and their higher-order assembly. HIV-1 encodes the regulatory protein Tat (86-101aa), which is essential for HIV-1 repl...

journal_title：Retrovirology

authors： Gautier VW,Gu L,O'Donoghue N,Pennington S,Sheehy N,Hall WW

更新日期：2009-05-19 00:00:00

abstract：:In HIV-infected people, resting CD4+ T cells are the main reservoir of latent virus and the reason for the failure of drug therapy to cure HIV infection. Still, we do not have a complete understanding of the factors regulating HIV replication in these cells. A recent paper in Cell describes a new trick that the virus ...

journal_title：Retrovirology

authors： Bukrinsky M

更新日期：2008-09-22 00:00:00

abstract：BACKGROUND:The human T-cell leukemia virus type 1 (HTLV-1) Tax protein indirectly influences transcriptional activation, signal transduction, cell cycle control, and apoptosis. The function of Tax primarily relies on protein-protein interactions. We have previously shown that Tax upregulates the cell cycle checkpoint p...

journal_title：Retrovirology

authors： Kehn K,Deng L,de la Fuente C,Strouss K,Wu K,Maddukuri A,Baylor S,Rufner R,Pumfery A,Bottazzi ME,Kashanchi F

更新日期：2004-04-13 00:00:00

abstract：BACKGROUND:We have previously reported that CD4 T cells from some exposed uninfected (EU) Vietnamese intravenous drug users are relatively resistant to HIV infection in vitro. Here, we further characterized the restriction of viral replication in CD4 T cells from five EUs and assessed its persistence in serial samples....

journal_title：Retrovirology

authors： Sáez-Cirión A,Versmisse P,Truong LX,Chakrabarti LA,Carpentier W,Barré-Sinoussi F,Scott-Algara D,Pancino G

更新日期：2006-11-08 00:00:00

abstract：:Sidaction's appeal regarding the sentencing of medical personnels in the Libyan-HIV infection cases. ...

journal_title：Retrovirology

authors： Fleutelot E

更新日期：2006-12-27 00:00:00

abstract：:HTLV-1 Tax can induce senescence by up-regulating the levels of cyclin-dependent kinase inhibitors p21(CIP1/WAF1) and p27(KIP1). Tax increases p27(KIP1) protein stability by activating the anaphase promoting complex/cyclosome (APC/C) precociously, causing degradation of Skp2 and inactivation of SCF(Skp2), the E3 ligas...

journal_title：Retrovirology

authors： Zhang L,Zhi H,Liu M,Kuo YL,Giam CZ

更新日期：2009-04-08 00:00:00

abstract：BACKGROUND:International travel plays a role in the spread of HIV-1 across Europe. It is, however, not known whether international travel is more important for spread of the epidemic as compared to endogenous infections within single countries. In this study, phylogenetic associations among HIV of newly diagnosed patie...

journal_title：Retrovirology

authors： Frentz D,Wensing AM,Albert J,Paraskevis D,Abecasis AB,Hamouda O,Jørgensen LB,Kücherer C,Struck D,Schmit JC,Åsjö B,Balotta C,Beshkov D,Camacho RJ,Clotet B,Coughlan S,De Wit S,Griskevicius A,Grossman Z,Horban A,Kolu

更新日期：2013-04-03 00:00:00

abstract：BACKGROUND:MicroRNA (miRNA)-mediated RNA silencing is integral to virtually every cellular process including cell cycle progression and response to virus infection. The interplay between RNA silencing and HIV-1 is multifaceted, and accumulating evidence posits a strike-counterstrike interface that alters the cellular e...

journal_title：Retrovirology

authors： Hayes AM,Qian S,Yu L,Boris-Lawrie K

更新日期：2011-05-13 00:00:00

abstract：BACKGROUND:It has been accepted that HIV buds from the cell surface in T lymphocytes, whereas in macrophages it buds into intracellular endosomes. Recent studies, on the other hand, suggest that HIV preferentially buds from the cell surface even in monocytic cells. However, most studies are based on observations in acu...

journal_title：Retrovirology

authors： Suyama M,Daikoku E,Goto T,Sano K,Morikawa Y

更新日期：2009-07-13 00:00:00

abstract：BACKGROUND:SAMHD1 is an HIV-1 restriction factor in non-dividing monocytes, dendritic cells (DCs), macrophages, and resting CD4+ T-cells. Acting as a deoxynucleoside triphosphate (dNTP) triphosphohydrolase, SAMHD1 hydrolyzes dNTPs and restricts HIV-1 infection in macrophages and resting CD4+ T-cells by decreasing the i...

journal_title：Retrovirology

authors： St Gelais C,de Silva S,Amie SM,Coleman CM,Hoy H,Hollenbaugh JA,Kim B,Wu L

更新日期：2012-12-11 00:00:00

abstract：BACKGROUND:Elderly HIV-1 infected individuals progress to AIDS more frequently and rapidly than people becoming infected at a young age. To identify possible reasons for these differences in clinical progression, we performed comprehensive phenotypic analyses of CD4+ T cells from uninfected young and elderly individual...

journal_title：Retrovirology

authors： Heigele A,Joas S,Regensburger K,Kirchhoff F

更新日期：2015-10-09 00:00:00

abstract：BACKGROUND:Certain murine leukemia viruses (MLVs) are capable of inducing progressive spongiform motor neuron disease in susceptible mice upon infection of the central nervous system (CNS). The major CNS parenchymal target of these neurovirulent retroviruses (NVs) are the microglia, whose infection is largely coinciden...

journal_title：Retrovirology

authors： Dimcheff DE,Volkert LG,Li Y,DeLucia AL,Lynch WP

更新日期：2006-05-12 00:00:00

abstract：BACKGROUND:HIV-1 infects a wide range of CD4+ T cells with different phenotypic properties and differing expression levels of entry coreceptors. We sought to determine the viral tropism of subtype C (C-HIV) Envelope (Env) clones for different CD4+ T cell subsets and whether tropism changes during acute to chronic disea...

journal_title：Retrovirology

authors： Gartner MJ,Gorry PR,Tumpach C,Zhou J,Dantanarayana A,Chang JJ,Angelovich TA,Ellenberg P,Laumaea AE,Nonyane M,Moore PL,Lewin SR,Churchill MJ,Flynn JK,Roche M

更新日期：2020-08-06 00:00:00

abstract：BACKGROUND:The HIV-1 Rev regulatory protein binds as an oligomeric complex to viral RNA mediating nuclear export of incompletely spliced and non-spliced viral mRNAs encoding the viral structural proteins. However, the biological significance of the obligatory complex formation of Rev upon the viral RNA is unclear. RES...

journal_title：Retrovirology

authors： Furnes C,Arnesen T,Askjaer P,Kjems J,Szilvay AM

更新日期：2005-06-10 00:00:00

abstract：BACKGROUND:The reliable diagnosis of human T-cell leukemia virus type 1 (HTLV-1) infection is important, particularly as it can be vertically transmitted by breast feeding mothers to their infants. However, current diagnosis in Japan requires a confirmatory western blot (WB) test after screening/primary testing for HTL...

journal_title：Retrovirology

authors： Okuma K,Kuramitsu M,Niwa T,Taniguchi T,Masaki Y,Ueda G,Matsumoto C,Sobata R,Sagara Y,Nakamura H,Satake M,Miura K,Fuchi N,Masuzaki H,Okayama A,Umeki K,Yamano Y,Sato T,Iwanaga M,Uchimaru K,Nakashima M,Utsunomiya A

更新日期：2020-08-24 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via the original article. ...

journal_title：Retrovirology

authors： Desimmie BA,Weydert C,Schrijvers R,Vets S,Demeulemeester J,Proost P,Paron I,De Rijck J,Mast J,Bannert N,Gijsbers R,Christ F,Debyser Z

更新日期：2020-07-29 00:00:00

abstract：BACKGROUND:Previous studies suggest that active selection limits the number of HIV-1 variants acquired by a newly infected individual from the diverse variants circulating in the transmitting partner. We compared HIV-1 envelopes from 9 newly infected subjects and their linked transmitting partner to explore potential m...

journal_title：Retrovirology

authors： Pena-Cruz V,Etemad B,Chatziandreou N,Nyein PH,Stock S,Reynolds SJ,Laeyendecker O,Gray RH,Serwadda D,Lee SJ,Quinn TC,Sagar M

更新日期：2013-12-26 00:00:00

abstract：:The viral transactivator of HTLV-I, Tax, has long been shown to target the earliest steps of transcription by forming quaternary complexes with sequence specific transcription factors and histone-modifying enzymes in the LTR of HTLV-I. However, a new study suggests that Tax preferentially transactivates the 21-bp repe...

journal_title：Retrovirology

authors： de la Fuente C,Kashanchi F

更新日期：2004-07-30 00:00:00

abstract：:The identification of the most appropriate marker to measure reservoir size has been a great challenge for the HIV field. Quantitative viral outgrowth assay (QVOA), the reference standard to quantify the amount of replication-competent virus, has several limitations, as it is laborious, expensive, and unable to robust...

journal_title：Retrovirology

authors： Pinzone MR,O'Doherty U

更新日期：2018-02-17 00:00:00

abstract：BACKGROUND:Jaagsiekte sheep retrovirus (JSRV) causes a contagious lung cancer in sheep and goats that can be transmitted by aerosols produced by infected animals. Virus entry into cells is initiated by binding of the viral envelope (Env) protein to a specific cell-surface receptor, Hyal2. Unlike almost all other retrov...

journal_title：Retrovirology

authors： Miller AD,De Las Heras M,Yu J,Zhang F,Liu SL,Vaughan AE,Vaughan TL,Rosadio R,Rocca S,Palmieri G,Goedert JJ,Fujimoto J,Wistuba II

更新日期：2017-01-20 00:00:00

abstract：BACKGROUND:Endogenous retroviruses (ERVs) are genetic elements with a retroviral origin that are integrated into vertebrate genomes. In felids (Mammalia, Carnivora, Felidae), ERVs have been described mostly in the domestic cat, and only rarely in wild species. To gain insight into the origins and evolutionary dynamics ...

journal_title：Retrovirology

authors： Mata H,Gongora J,Eizirik E,Alves BM,Soares MA,Ravazzolo AP

更新日期：2015-03-15 00:00:00

abstract：BACKGROUND:The widespread use of highly effective, combination antiretroviral therapy (cART) has led to a significant reduction in the incidence of HIV-associated dementia (HAD). Despite these advances, the prevalence of HIV-1 associated neurocognitive disorders (HANDs) has been estimated at approximately 40%-50%. In t...

journal_title：Retrovirology

authors： Evering TH,Kamau E,St Bernard L,Farmer CB,Kong XP,Markowitz M

更新日期：2014-08-15 00:00:00

abstract：BACKGROUND:The continued persistence of HIV-1 as a public health concern due to the lack of a cure calls for the development of new tools for studying replication of the virus. Here, we used NanoLuc, a small and extremely bright luciferase protein, to develop an HIV-1 bioluminescent reporter virus that simplifies funct...

journal_title：Retrovirology

authors： Kirui J,Freed EO

更新日期：2020-05-19 00:00:00

abstract：BACKGROUND:In chickens, as in most birds, female gonad morphogenesis is asymmetrical. Gonads appear first rather similarly, but only the left one undergoes full differentiation and gives rise to a functional ovary. The right gonad, in which the cortex does not develop, remains restricted to the medulla and finally regr...

journal_title：Retrovirology

authors： Carré-Eusèbe D,Coudouel N,Magre S

更新日期：2009-06-17 00:00:00

abstract：:Correlates of protection (CoPs) against infection by primate lentiviruses remain undefined. Modest protection against HIV-1 was observed in one human vaccine trial, whereas previous trials and vaccine-challenge experiments in non-human primates have yielded inconsistent but intriguing results. Although high levels of ...

journal_title：Retrovirology

authors： Klasse PJ,Moore JP

更新日期：2012-10-01 00:00:00

abstract：BACKGROUND:Formation of a mature core is a crucial event for infectivity of retroviruses such as Mason-Pfizer monkey virus (M-PMV). The process is triggered by proteolytic cleavage of the polyprotein precursor Gag, which releases matrix, capsid (CA), and nucleocapsid proteins. Once released, CA assembles to form a matu...

journal_title：Retrovirology

authors： Obr M,Hadravová R,DoleŽal M,KříŽová I,Papoušková V,Zídek L,Hrabal R,Ruml T,Rumlová M

更新日期：2014-10-30 00:00:00

abstract：BACKGROUND:Chemokine receptors (CKRs), the primordial receptors for primate lentiviruses, are sufficient to mediate virus-cell fusion. Several different fusogenic CKRs and related receptors provide a broad potential host cell range, presumably advantageous for viral spread within a given infected individual, and across...

journal_title：Retrovirology

authors： Iyengar S,Schwartz DH

更新日期：2012-07-25 00:00:00

abstract：BACKGROUND:HIV infection results in inhibited cholesterol efflux by apolipoprotein A-I (apoA-I) in macrophages, and this impairment involves Nef mediated down-regulation and redistribution of ATP-binding cassette transporter A1 (ABCA-1). We investigated the effect of caveolin-1 (Cav-1) on the cholesterol efflux by apoA...

journal_title：Retrovirology

authors： Lin S,Nadeau PE,Wang X,Mergia A

更新日期：2012-10-15 00:00:00

abstract：BACKGROUND:Early HIV-1 infection causes massive CD4+ T cell death in the gut and translocation of bacteria into the circulation. However, the programmed cell death (PCD) pathways used by HIV-1 to kill CD4+ T cells in the gut, and the impact of microbial exposure on T cell loss, remain unclear. Understanding mucosal HIV...

journal_title：Retrovirology

authors： Steele AK,Lee EJ,Manuzak JA,Dillon SM,Beckham JD,McCarter MD,Santiago ML,Wilson CC

更新日期：2014-02-04 00:00:00