Abstract:
:The viral transactivator of HTLV-I, Tax, has long been shown to target the earliest steps of transcription by forming quaternary complexes with sequence specific transcription factors and histone-modifying enzymes in the LTR of HTLV-I. However, a new study suggests that Tax preferentially transactivates the 21-bp repeats through CREB1 and not other bZIP proteins. The additional transactivation of Tax-responsive promoters subsequent to initiation is also presented. This result highlights a potentially novel role of Tax following TBP recruitment (i.e. initiation) and may expand the mechanism of Tax transactivation in promoter clearance and transcriptional elongation.
journal_name
Retrovirologyjournal_title
Retrovirologyauthors
de la Fuente C,Kashanchi Fdoi
10.1186/1742-4690-1-19subject
Has Abstractpub_date
2004-07-30 00:00:00pages
19issn
1742-4690pii
1742-4690-1-19journal_volume
1pub_type
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