SARS: systematic review of treatment effects.

abstract：:Drawing upon interviews with experts and a review of the literature, Gavin Yamey proposes a new framework for scaling up global health interventions. ...

journal_title：PLoS medicine

authors： Yamey G

更新日期：2011-06-01 00:00:00

abstract：BACKGROUND:As the number of HIV-infected women initiating lifelong antiretroviral therapy (ART) during pregnancy increases globally, concerns have emerged regarding low levels of retention in HIV services and suboptimal adherence to ART during the postpartum period. We examined the impact of integrating postpartum ART ...

journal_title：PLoS medicine

authors： Myer L,Phillips TK,Zerbe A,Brittain K,Lesosky M,Hsiao NY,Remien RH,Mellins CA,McIntyre JA,Abrams EJ

更新日期：2018-03-30 00:00:00

abstract：BACKGROUND:Important differences exist in the diagnosis of malnutrition when comparing the 2006 World Health Organization (WHO) Child Growth Standards and the 1977 National Center for Health Statistics (NCHS) reference. However, their relationship with mortality has not been studied. Here, we assessed the accuracy of t...

journal_title：PLoS medicine

authors： Lapidus N,Luquero FJ,Gaboulaud V,Shepherd S,Grais RF

更新日期：2009-03-03 00:00:00

abstract：BACKGROUND:To reduce the risk of drug-induced haemolysis, all patients should be tested for glucose-6-phosphate dehydrogenase (G6PD) deficiency (G6PDd) prior to prescribing primaquine (PQ)-based radical cure for the treatment of vivax malaria. This systematic review and individual patient meta-analysis assessed the uti...

journal_title：PLoS medicine

authors： Ley B,Winasti Satyagraha A,Rahmat H,von Fricken ME,Douglas NM,Pfeffer DA,Espino F,von Seidlein L,Henriques G,Oo NN,Menard D,Parikh S,Bancone G,Karahalios A,Price RN

更新日期：2019-12-13 00:00:00

abstract：BACKGROUND:Pediatric acute lymphoblastic leukemia (ALL) is the most common childhood cancer and the leading cause of cancer-related mortality in children. T cell ALL (T-ALL) represents about 15% of pediatric ALL cases and is considered a high-risk disease. T-ALL is often associated with resistance to treatment, includi...

journal_title：PLoS medicine

authors： Li Y,Buijs-Gladdines JG,Canté-Barrett K,Stubbs AP,Vroegindeweij EM,Smits WK,van Marion R,Dinjens WN,Horstmann M,Kuiper RP,Buijsman RC,Zaman GJ,van der Spek PJ,Pieters R,Meijerink JP

更新日期：2016-12-20 00:00:00

abstract：BACKGROUND:A nonsputum blood test capable of predicting progression of healthy individuals to active tuberculosis (TB) before clinical symptoms manifest would allow targeted treatment to curb transmission. We aimed to develop a proteomic biomarker of risk of TB progression for ultimate translation into a point-of-care ...

journal_title：PLoS medicine

authors： Penn-Nicholson A,Hraha T,Thompson EG,Sterling D,Mbandi SK,Wall KM,Fisher M,Suliman S,Shankar S,Hanekom WA,Janjic N,Hatherill M,Kaufmann SHE,Sutherland J,Walzl G,De Groote MA,Ochsner U,Zak DE,Scriba TJ,ACS and GC6–74

更新日期：2019-04-16 00:00:00

abstract：:Antimalarial drugs will be essential tools at all stages of malaria elimination along the path towards eradication, including the early control or "attack" phase to drive down transmission and the later stages of maintaining interruption of transmission, preventing reintroduction of malaria, and eliminating the last r...

journal_title：PLoS medicine

authors： malERA Consultative Group on Drugs.

更新日期：2011-01-25 00:00:00

abstract：BACKGROUND:Psychosis is a severe mental condition that is characterized by a loss of contact with reality and is typically associated with hallucinations and delusional beliefs. There are numerous psychiatric conditions that present with psychotic symptoms, most importantly schizophrenia, bipolar affective disorder, an...

journal_title：PLoS medicine

authors： Huang JT,Leweke FM,Oxley D,Wang L,Harris N,Koethe D,Gerth CW,Nolden BM,Gross S,Schreiber D,Reed B,Bahn S

更新日期：2006-11-01 00:00:00

abstract：BACKGROUND:Bilharzia is one of the major parasitic infections affecting the public health and socioeconomic circumstances in (sub) tropical areas. Its causative agents are schistosomes. Since these worms remain in their host for decades, they have developed mechanisms to evade or resist the immune system. Like several ...

journal_title：PLoS medicine

authors： Sprong H,Suchanek M,van Dijk SM,van Remoortere A,Klumperman J,Avram D,van der Linden J,Leusen JH,van Hellemond JJ,Thiele C

更新日期：2006-08-01 00:00:00

abstract：:David Studdert and colleagues explore how to balance public health, individual freedom, and good government when it comes to sugar-sweetened drinks. ...

journal_title：PLoS medicine

authors： Studdert DM,Flanders J,Mello MM

更新日期：2015-07-07 00:00:00

abstract：:A major challenge in monitoring universal health coverage (UHC) is identifying an indicator that can adequately capture the multiple components underlying the UHC initiative. Effective coverage, which unites individual and intervention characteristics into a single metric, offers a direct and flexible means to measure...

journal_title：PLoS medicine

authors： Ng M,Fullman N,Dieleman JL,Flaxman AD,Murray CJ,Lim SS

更新日期：2014-09-22 00:00:00

abstract：:H. Bart van der Worp and colleagues discuss the controversies and possibilities of translating the results of animal experiments into human clinical trials. ...

journal_title：PLoS medicine

authors： van der Worp HB,Howells DW,Sena ES,Porritt MJ,Rewell S,O'Collins V,Macleod MR

更新日期：2010-03-30 00:00:00

abstract：:In this month's editorial, PLOS Medicine's Chief Editor Larry Peiperl discusses the relevance of patient care to a journal editor's work. ...

journal_title：PLoS medicine

authors： Peiperl L,PLOS Medicine Editors.

更新日期：2017-09-26 00:00:00

abstract：BACKGROUND:The World Health Organization (WHO) released revised guidelines in 2015 recommending that all people living with HIV, regardless of CD4 count, initiate antiretroviral therapy (ART) upon diagnosis. However, few studies have projected the global resources needed for rapid scale-up of ART. Under the Health Poli...

journal_title：PLoS medicine

authors： Dutta A,Barker C,Kallarakal A

更新日期：2015-11-24 00:00:00

abstract：BACKGROUND:Identifying stage II patients with colorectal cancer (CRC) at higher risk of progression is a clinical priority in order to optimize the advantages of adjuvant chemotherapy while avoiding unnecessary toxicity. Recently, the intensity and the quality of the host immune response in the tumor microenvironment h...

journal_title：PLoS medicine

authors： Sanz-Pamplona R,Melas M,Maoz A,Schmit SL,Rennert H,Lejbkowicz F,Greenson JK,Sanjuan X,Lopez-Zambrano M,Alonso MH,Qu C,McDonnell KJ,Idos GE,Vignali M,Emerson R,Fields P,Guinó E,Santos C,Salazar R,Robins HS,Rennert

更新日期：2020-09-24 00:00:00

abstract：BACKGROUND:Outbreaks of emerging infectious diseases, especially those of a global nature, require rapid epidemiological analysis and information dissemination. The final products of those activities usually comprise internal memoranda and briefs within public health authorities and original research published in peer-...

journal_title：PLoS medicine

authors： Xing W,Hejblum G,Leung GM,Valleron AJ

更新日期：2010-05-04 00:00:00

abstract：BACKGROUND:Postpartum hemorrhage (PPH) is a leading cause of maternal death in sub-Saharan Africa. Although the World Health Organization recommends use of oxytocin for prevention of PPH, misoprostol use is increasingly common owing to advantages in shelf life and potential for sublingual administration. There is a lac...

journal_title：PLoS medicine

authors： Atukunda EC,Siedner MJ,Obua C,Mugyenyi GR,Twagirumukiza M,Agaba AG

更新日期：2014-11-04 00:00:00

abstract：:Mirjam Kretzschmar and colleagues describe the BCoDE project, which uses a pathogen-based incidence approach to better estimate the infectious disease burden in Europe. ...

journal_title：PLoS medicine

authors： Kretzschmar M,Mangen MJ,Pinheiro P,Jahn B,Fèvre EM,Longhi S,Lai T,Havelaar AH,Stein C,Cassini A,Kramarz P,BCoDE consortium.

更新日期：2012-01-01 00:00:00

abstract：:[This corrects the article DOI: 10.1371/journal.pmed.1002781.]. ...

journal_title：PLoS medicine

authors： Penn-Nicholson A,Hraha T,Thompson EG,Sterling D,Mbandi SK,Wall KM,Fisher M,Suliman S,Shankar S,Hanekom WA,Janjic N,Hatherill M,Kaufmann SHE,Sutherland J,Walzl G,De Groote MA,Ochsner U,Zak DE,Scriba TJ,ACS and GC6–74

更新日期：2019-07-18 00:00:00

abstract：BACKGROUND:Patients with unprovoked (i.e., without the presence of apparent transient risk factors such as recent surgery) venous thromboembolism (VTE) are at risk of recurrence if anticoagulants are stopped after 3-6 months, yet their risk remains heterogeneous. Thus, prolonging anticoagulant treatment should be consi...

journal_title：PLoS medicine

authors： Geersing GJ,Hendriksen JMT,Zuithoff NPA,Roes KC,Oudega R,Takada T,Schutgens REG,Moons KGM

更新日期：2020-06-26 00:00:00

abstract：BACKGROUND:Since 1998 the serious public health problem in South East Asia of counterfeit artesunate, containing no or subtherapeutic amounts of the active antimalarial ingredient, has led to deaths from untreated malaria, reduced confidence in this vital drug, large economic losses for the legitimate manufacturers, an...

journal_title：PLoS medicine

authors： Newton PN,Fernández FM,Plançon A,Mildenhall DC,Green MD,Ziyong L,Christophel EM,Phanouvong S,Howells S,McIntosh E,Laurin P,Blum N,Hampton CY,Faure K,Nyadong L,Soong CW,Santoso B,Zhiguang W,Newton J,Palmer K

更新日期：2008-02-01 00:00:00

abstract：BACKGROUND:Despite repeated outbreaks, in particular the devastating 2014-2016 epidemic, there is no effective treatment validated for patients with Ebola virus disease (EVD). Among the drug candidates is the broad-spectrum polymerase inhibitor favipiravir, which showed a good tolerance profile in patients with EVD (JI...

journal_title：PLoS medicine

authors： Guedj J,Piorkowski G,Jacquot F,Madelain V,Nguyen THT,Rodallec A,Gunther S,Carbonnelle C,Mentré F,Raoul H,de Lamballerie X

更新日期：2018-03-27 00:00:00

abstract：:Community efforts and peer support programs are needed in addition to provider-initiated and opt-out HIV testing in adolescents, Sheri Weiser and colleagues discuss. ...

journal_title：PLoS medicine

authors： Lightfoot M,Dunbar M,Weiser SD

更新日期：2017-07-25 00:00:00

abstract：BACKGROUND:TKM-130803, a small interfering RNA lipid nanoparticle product, has been developed for the treatment of Ebola virus disease (EVD), but its efficacy and safety in humans has not been evaluated. METHODS AND FINDINGS:In this single-arm phase 2 trial, adults with laboratory-confirmed EVD received 0.3 mg/kg of T...

journal_title：PLoS medicine

authors： Dunning J,Sahr F,Rojek A,Gannon F,Carson G,Idriss B,Massaquoi T,Gandi R,Joseph S,Osman HK,Brooks TJ,Simpson AJ,Goodfellow I,Thorne L,Arias A,Merson L,Castle L,Howell-Jones R,Pardinaz-Solis R,Hope-Gill B,Ferri M,

更新日期：2016-04-19 00:00:00

abstract：BACKGROUND:It remains unclear when standard systematic reviews and meta-analyses that rely on published aggregate data (AD) can provide robust clinical conclusions. We aimed to compare the results from a large cohort of systematic reviews and meta-analyses based on individual participant data (IPD) with meta-analyses o...

journal_title：PLoS medicine

authors： Tierney JF,Fisher DJ,Burdett S,Stewart LA,Parmar MKB

更新日期：2020-01-31 00:00:00

abstract：:[This corrects the article DOI: 10.1371/journal.pmed.1001659.]. ...

journal_title：PLoS medicine

authors： PLOS Medicine Staff.

更新日期：2015-03-03 00:00:00

abstract：BACKGROUND:The alpha-thalassaemias are the commonest genetic disorders of humans. It is generally believed that this high frequency reflects selection through a survival advantage against death from malaria; nevertheless, the epidemiological description of the relationships between alpha-thalassaemia, malaria, and othe...

journal_title：PLoS medicine

authors： Wambua S,Mwangi TW,Kortok M,Uyoga SM,Macharia AW,Mwacharo JK,Weatherall DJ,Snow RW,Marsh K,Williams TN

更新日期：2006-05-01 00:00:00

abstract：BACKGROUND:trans-fatty acids (TFAs) are a well-known risk factor of ischemic heart disease (IHD). In Australia, the highest TFA intake is concentrated to the most socioeconomically disadvantaged groups. Elimination of industrial TFA (iTFA) from the Australian food supply could result in reduced IHD mortality and morbid...

journal_title：PLoS medicine

authors： Marklund M,Zheng M,Veerman JL,Wu JHY

更新日期：2020-11-02 00:00:00

abstract：BACKGROUND:Psoriasis is a common inflammatory skin disease that has been reported to be associated with obesity. We aimed to investigate a possible causal relationship between body mass index (BMI) and psoriasis. METHODS AND FINDINGS:Following a review of published epidemiological evidence of the association between o...

journal_title：PLoS medicine

authors： Budu-Aggrey A,Brumpton B,Tyrrell J,Watkins S,Modalsli EH,Celis-Morales C,Ferguson LD,Vie GÅ,Palmer T,Fritsche LG,Løset M,Nielsen JB,Zhou W,Tsoi LC,Wood AR,Jones SE,Beaumont R,Saunes M,Romundstad PR,Siebert S,McInn

更新日期：2019-01-31 00:00:00

abstract：BACKGROUND:Assessing the mortality impact of the 2009 influenza A H1N1 virus (H1N1pdm09) is essential for optimizing public health responses to future pandemics. The World Health Organization reported 18,631 laboratory-confirmed pandemic deaths, but the total pandemic mortality burden was substantially higher. We estim...

journal_title：PLoS medicine

authors： Simonsen L,Spreeuwenberg P,Lustig R,Taylor RJ,Fleming DM,Kroneman M,Van Kerkhove MD,Mounts AW,Paget WJ,GLaMOR Collaborating Teams.

更新日期：2013-11-01 00:00:00