Synaptic control of motoneuron excitability in rodents: from months to milliseconds.


:1. Motoneurons (MN) shape motor patterns by transforming inputs into action potential output. This transformation, excitability, is determined by an interaction between synaptic inputs and intrinsic membrane properties. Excitability is not static, but changes over multiple time scales. The purpose of the present paper is to review our recent data on synaptic factors important in the dynamic control of MN excitability over time scales ranging from weeks to milliseconds. 2. Developmental changes in modulation of MN excitability are well established. Noradrenergic potentiation of hypoglossal (XII) MN inspiratory activity in rhythmically active medullary slice preparations from rodents increases during the first two postnatal weeks. This is due to increasing alpha 1- and beta-adrenoceptor excitatory mechanisms and to a decreasing inhibitory mechanism mediated by alpha 2-adrenoceptors. Over a similar period, ATP potentiation of XII inspiratory activity does not change. 3. Motoneuron excitability may also change on a faster time scale, such as between different behaviours or different phases of a behaviour. Examination of this has been confounded by the fact that excitatory synaptic drives underlying behaviour can obscure smaller concurrent changes in excitability. Using the rhythmically active neonatal rat brain-stem-spinal cord preparation, we blocked excitatory inspiratory drive to phrenic MN (PMN) to reveal a reduction in PMN excitability specific to the inspiratory phase that: (i) arises from an inhibitory GABAergic input; (ii) is not mediated by recurrent pathways; and (iii) is proportional to and synchronous with the excitatory inspiratory input. We propose that the proportionality of the concurrent inhibitory and excitatory drives provides a means for phase-specific modulation of PMN gain. 4. Modulation across such diverse time scales emphasizes the active role that synaptic factors play in controlling MN excitability and shaping behaviour.


Funk GD,Parkis MA,Selvaratnam SR,Robinson DM,Miles GB,Peebles KC





Has Abstract


2000-01-01 00:00:00












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    pub_type: 杂志文章,评审


    authors: Mitchelson F,Choo LK,Darroch S

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  • Ion channels, long QT syndrome and arrhythmogenesis in ageing.

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    pub_type: 杂志文章,评审


    authors: Jeevaratnam K,Chadda KR,Salvage SC,Valli H,Ahmad S,Grace AA,Huang CL

    更新日期:2017-12-01 00:00:00

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    authors: Hoffman WE,Miletich DJ,Volkman PH,Albrecht RF

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    authors: Ziogas J,Story DF,Rand MJ

    更新日期:1984-07-01 00:00:00

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    authors: Cheng ZB,Kobayashi M,Nosaka S

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    authors: Chang W,Wang Y,Li W,Geng Z

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  • Cellular calcium regulatory machinery of vasorelaxation elicited by petasin.

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    pub_type: 杂志文章


    authors: Wang GJ,Lin YL,Chen CH,Wu XC,Liao JF,Ren J

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    authors: Wach RA,Gill GW,Suggett AJ,Bee D,Barer G

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    pub_type: 杂志文章


    authors: Dart AM,Riemersma RA

    更新日期:1991-01-01 00:00:00

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    authors: Falckh PH,Harkin LA,Head RJ

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    authors: Lucafò M,Bravin V,Tommasini A,Martelossi S,Rabach I,Ventura A,Decorti G,De Iudicibus S

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    authors: Wang Q,Horisberger JD,Maillard M,Brunner HR,Rossier BC,Burnier M

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  • Uneven changes in circulating blood cell counts with adrenergic stimulation to the canine spleen.

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    pub_type: 杂志文章


    authors: Kurpad AV,Shetty PS

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    authors: Winterhager E,Reuss B,Hellmann P,Spray DC,Gruemmer R

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  • Key mechanisms underlying netrin-1 prevention of impaired spatial and object memory in Aβ1-42 CA1-injected rats.

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    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Zamani E,Parviz M,Roghani M,Mohseni-Moghaddam P

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    pub_type: 杂志文章


    authors: Kawano Y,Yoshida K,Kawamura M,Yoshimi H,Ashida T,Abe H,Imanishi M,Kimura G,Kojima S,Kuramochi M

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    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Aydogdu N,Atmaca G,Yalcin O,Taskiran R,Tastekin E,Kaymak K

    更新日期:2006-01-01 00:00:00

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    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Kotecha N,Neild TO

    更新日期:1986-03-01 00:00:00

  • Antihypertensive effects of DL-tetrahydropalmatine: an active principle isolated from Corydalis.

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    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Lin MT,Chueh FY,Hsieh MT,Chen CF

    更新日期:1996-08-01 00:00:00

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    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Chu ZM,Beilin LJ

    更新日期:1997-06-01 00:00:00

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    pub_type: 杂志文章


    authors: Krzanowski JJ,Polson JB,Goldman AL,Ebel TA,Szentivanyi A

    更新日期:1979-01-01 00:00:00

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    pub_type: 杂志文章


    authors: Raghavendran HB,Sathivel A,Yogeeta RS,Devaki T

    更新日期:2007-03-01 00:00:00