Cardiovascular actions of human endothelin in conscious sheep.


:1. Synthetic human endothelin was injected intravenously over the range 1.5-50 micrograms to examine its cardiovascular actions in conscious sheep. 2. Mean arterial pressure increased by 9-21 mmHg within 30-120 s over the range 5-50 micrograms endothelin. The increase in blood pressure was associated with increased calculated total peripheral resistance and a fall in cardiac output and heart rate. Stroke volume was increased. 3. Injection of endothelin into ganglion blocked sheep produced vasoconstriction and an increased blood pressure response associated with an attenuation of the effects on cardiac output, heart rate and stroke volume. 4. This study suggests that endothelin produces potent arterial vasoconstriction and reflex mediated effects on the heart in conscious sheep.


Scoggins BA,Spence CD,Parkes DG,McDonald M,Wade JD,Coghlan JP




Has Abstract


1989-04-01 00:00:00












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    pub_type: 杂志文章


    authors: Nguyen-Simonnet H,Gauthier C,Pellet M

    更新日期:1981-07-01 00:00:00

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    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章,评审


    authors: Welch WJ

    更新日期:2006-10-01 00:00:00

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    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Pinkham MI,Barrett CJ

    更新日期:2015-06-01 00:00:00

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    authors: Chen B,Strauch K,Jin Y,Cui H,Nelin LD,Chicoine LG

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    journal_title:Clinical and experimental pharmacology & physiology

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    authors: Kaufman S

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    journal_title:Clinical and experimental pharmacology & physiology

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    pub_type: 杂志文章,评审


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    更新日期:1999-12-01 00:00:00

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    journal_title:Clinical and experimental pharmacology & physiology

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    pub_type: 杂志文章


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    journal_title:Clinical and experimental pharmacology & physiology

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    journal_title:Clinical and experimental pharmacology & physiology

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    journal_title:Clinical and experimental pharmacology & physiology

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    authors: Tsi D,Tan BK

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