Ferulic acid alleviates symptoms of preeclampsia in rats by upregulating vascular endothelial growth factor.

abstract：:1. It has been proposed that hypertension alters the respiratory and cardiovascular responses to chemoreceptor stimulation. However, in studies of human hypertension or in genetic animal models of hypertension it has been difficult to unequivocally attribute the changes to hypertension per se, rather than to a genetic...

journal_title：Clinical and experimental pharmacology & physiology

authors： Groom AS,Malpas SC

更新日期：1997-03-01 00:00:00

abstract：:1. Calcified arteriosclerotic lesions have been recognized early in life as abnormalities in coronary arteries. 2. We examined coronary arterial plaques as an undecalcified tissue and revealed widespread mineralization within the plaque. Non-collagenous proteins that regulate calcification, such as osteopontin, have b...

journal_title：Clinical and experimental pharmacology & physiology

authors： Fitzpatrick LA

更新日期：1996-03-01 00:00:00

abstract：:1. The effects of the alpha-beta-adrenergic antagonist labetalol on the activation of human platelets by adrenaline and other aggregating stimuli have been investigated. 2. Labetalol inhibited platelet aggregation and secretion induced by collagen and the second phase of aggregation caused by ADP, platelet activating ...

journal_title：Clinical and experimental pharmacology & physiology

authors： Anfossi G,Trovati M,Lanzio M,Mularoni E,Massucco P,Emanuelli G

更新日期：1988-06-01 00:00:00

abstract：:1. Anastomosis (vasovasostomy) of epididymal and prostatic halves of vasa deferentia was carried out in rats in which unilateral or bilateral medial transection (vasectomy) had been performed 4 weeks previously. 2. Noradrenaline levels in epididymal halves of vasa deferentia, 8 weeks after anastomosis with prostatic h...

journal_title：Clinical and experimental pharmacology & physiology

authors： DeGaris RM,Pennefather JN

更新日期：1987-05-01 00:00:00

abstract：:1. mu-Opioid receptor agonists mediate their central analgesic effects by actions on neurons within brain regions such as the mid-brain periaqueductal grey (PAG). Within the PAG, mu-opioid receptor-mediated analgesia results from inhibition of GABAergic influences on output projection neurons. We have established that...

journal_title：Clinical and experimental pharmacology & physiology

authors： Christie MJ,Connor M,Vaughan CW,Ingram SL,Bagley EE

更新日期：2000-07-01 00:00:00

abstract：:1. Twelve treated hypertensive patients (ages 58-71 years) who had also been treated for joint disease participated in a randomized double-blind crossover placebo-controlled study to investigate the effects of indomethacin (25 mg three times daily) on blood pressure and biochemical parameters over a 6-week period. 2. ...

journal_title：Clinical and experimental pharmacology & physiology

authors： Wing LM,Bune AJ,Chalmers JP,Graham JR,West MJ

更新日期：1981-09-01 00:00:00

abstract：:1. The common pathological alteration in virtually every progressive chronic kidney disease (CKD) is renal fibrosis. 2. This review focuses on some growth factors, which are particularly well-established in contributing to fibrosis, such as the profibrotic, transforming growth factor-β, and connective tissue growth fa...

journal_title：Clinical and experimental pharmacology & physiology

authors： Boor P,Floege J

更新日期：2011-07-01 00:00:00

abstract：:1. (-)[125I]-Cyanopindolol (CYP) binding to non-beta-adrenoceptor sites in dog kidney was characterized in homogenate preparations and their distribution in sections determined using autoradiography. 2. In homogenate studies, (-)[125I]-CYP bound to a single population of non-interacting sites (Bmax = 5.45, s.e.m. = 1....

journal_title：Clinical and experimental pharmacology & physiology

authors： Lew R,Summers RJ

更新日期：1987-09-01 00:00:00

abstract：:1. Angiotensin (Ang)II is involved in responses to hypovolaemia, such as sodium appetite and increase in blood pressure. Target areas subserving these responses for AngII include the cardiovascular system in the periphery and the circumventricular organs in the brain. 2. Conflicting data have been reported for the rol...

journal_title：Clinical and experimental pharmacology & physiology

authors： De Luca LA Jr,Sugawara AM,Menani JV

更新日期：2000-05-01 00:00:00

abstract：:MicroRNA plays an integral role in the development of atherosclerosis. Our study aimed to investigate the roles of miR-599 in lipopolysaccharide (LPS)-induced endothelial damage in human umbilical vein endothelial cells (HUVECs). HUVECs were transfected with a miR-599 mimic and negative control, and then exposed to LP...

journal_title：Clinical and experimental pharmacology & physiology

authors： Wang J,Du A,Wang H,Li Y

更新日期：2020-08-01 00:00:00

abstract：:Lamotrigine (LTG) is one of the most widely used antiepileptic drugs. Confusion still exists in the literature as to the relative influence of age, body weight, and concomitant drug therapy on LTG pharmacokinetics. So, the objective of this study is to evaluate the influence of patient-related factors and comedication...

journal_title：Clinical and experimental pharmacology & physiology

authors： Baldoni AO,Freitas-Lima P,de Santi Ferreira FI,Martinez EZ,Queiroz RH,Sakamoto AC,Alexandre V,Perucca E,Pereira LR

更新日期：2016-07-01 00:00:00

abstract：:1. Anoxic perfusion of the isolated rat heart releases noradrenaline in the absence of sympathetic nerve fibre stimulation. 2. Anoxic noradrenaline release is enhanced by reducing the extracellular Na+ concentration, consistent with the proposal that such release occurs by carrier-mediated efflux. 3. Release is also e...

journal_title：Clinical and experimental pharmacology & physiology

authors： Dart AM,Riemersma RA

更新日期：1991-01-01 00:00:00

abstract：:1. The use of the isolated lung strip and single open tracheal ring for studying Schultz Dale anaphylactic contractions in both the peripheral and central airways is described. 2. This method is particularly relevant to studies of anaphylaxis because many preparations may be obtained from a single sensitized animal. 3...

journal_title：Clinical and experimental pharmacology & physiology

authors： Lulich KM,Papadimitriou JM,Paterson JW

更新日期：1979-11-01 00:00:00

abstract：:1. Renomedullary interstitial cells (RMIC), abundant throughout the medulla of the kidney, have been demonstrated to have binding sites for many vasoactive peptides, including atrial natriuretic peptide, endothelin, angiotensin II and bradykinin (BK). These observations would support the hypothesis that interactions b...

journal_title：Clinical and experimental pharmacology & physiology

authors： Dean R,Maric C,Aldred GP,Casley D,Zhuo J,Harris P,Alcorn D,Mendelsohn FA

更新日期：1999-01-01 00:00:00

abstract：:1. Dexamethasone (Dex)-induced hypertension is characterized by endothelial dysfunction associated with nitric oxide (NO) deficiency and increased superoxide (O2-) production. Atorvastatin (Ato) possesses pleiotropic properties that have been reported to improve endothelial function through increased availability of N...

journal_title：Clinical and experimental pharmacology & physiology

authors： Mondo CK,Yang WS,Zhang N,Huang TG

更新日期：2006-11-01 00:00:00

abstract：:1. The calcineurin inhibitor cyclosporine is widely used to prevent allograft rejection after solid organ transplantation. It has a narrow therapeutic index and shows considerable interindividual differences in its pharmacokinetics. Interindividual differences in the activity and expression of the metabolising enzymes...

journal_title：Clinical and experimental pharmacology & physiology

authors： Hu YF,Qiu W,Liu ZQ,Zhu LJ,Liu ZQ,Tu JH,Wang D,Li Z,He J,Zhong GP,Zhou G,Zhou HH

更新日期：2006-11-01 00:00:00

abstract：:The effects of inflammatory changes on the absorption of different-sized probes and their permeability ratios are poorly understood. The aim of the present study was to determine the effects of a pharmacological agent on the permeability of the gut mucosa to saccharidic probes of larger and smaller molecular weight. P...

journal_title：Clinical and experimental pharmacology & physiology

authors： Sequeira IR,Lentle RG,Kruger MC,Hurst RD

更新日期：2014-02-01 00:00:00

abstract：:1. Breast cancer resistance protein (BCRP, ABCG2) is a drug efflux transporter that is believed to affect the drug disposition of several drugs and xenobiotics. In the present study, we evaluated the localization and functional expression of BCRP in the human choriocarcinoma cell line BeWo, an in vitro model of the hu...

journal_title：Clinical and experimental pharmacology & physiology

authors： Ceckova M,Libra A,Pavek P,Nachtigal P,Brabec M,Fuchs R,Staud F

更新日期：2006-01-01 00:00:00

abstract：:1. Hepatic resection with concomitant periods of ischaemia and reperfusion (I/R) is required to perform reduced-size liver (RSL) transplantation procedures, such as living donor or split liver transplantation. Although a great deal of progress has been made using these types of surgical procedures, a significant numbe...

journal_title：Clinical and experimental pharmacology & physiology

authors： Urakami H,Abe Y,Grisham MB

更新日期：2007-09-01 00:00:00

abstract：:1. Two aspects of cholesterol absorption; (a) the importance of solubilization and (b) the effects of different bile salts on the mucosal metabolism and lymphatic output of cholesterol, have been investigated using two different in vivo techniques. 2. Bile diverted lymph fistula rats were infused intraduodenally at a ...

journal_title：Clinical and experimental pharmacology & physiology

authors： Watt SM,Simmonds WJ

更新日期：1976-07-01 00:00:00

abstract：:The kidney has a unique environment that results in relatively low tissue oxygen tension (Po2). However, recent studies have shown that renal hypoxia is more severe during hypertension and may reflect changes in the way O2 is used. The present review summarizes studies that explore the relationship between renal oxyge...

journal_title：Clinical and experimental pharmacology & physiology

authors： Welch WJ

更新日期：2006-10-01 00:00:00

abstract：:1. Protease-activated receptor 2 (PAR2), present in capsaicin-sensitive sensory neurons, induces gastric mucus secretion and mucosal cytoprotection. 2. We studied the possible cross-talk between PAR2 and vanilloid receptor 1 (VR1). The VR1 antagonist capsazepine partially inhibited the PAR2-mediated increase in gastri...

journal_title：Clinical and experimental pharmacology & physiology

authors： Kawabata A,Kinoshita M,Kuroda R,Kakehi K

更新日期：2002-04-01 00:00:00

abstract：:Cannabinoid inverse agonists possess antidepressant-like properties, but the mechanism of this action is unknown. Numerous studies have reported the interaction between opioid and cannabinoid pathways. In this study, acute foot-shock stress was used in mice to investigate the involvement of the opioid pathway in the a...

journal_title：Clinical and experimental pharmacology & physiology

authors： Ostadhadi S,Haj-Mirzaian A,Nikoui V,Kordjazy N,Dehpour AR

更新日期：2016-02-01 00:00:00

abstract：:1. The present study was undertaken to investigate the effects of aerobic physical exercise on membrane function in mild essential hypertension. 2. Hypertensive patients were divided into an exercise group (n = 8) and a non-exercise (control) group (n = 8). Physical exercise within the intensity of the anaerobic thres...

journal_title：Clinical and experimental pharmacology & physiology

authors： Tsuda K,Yoshikawa A,Kimura K,Nishio I

更新日期：2003-05-01 00:00:00

abstract：:Summary 1. The non-selective K(+) channel blocker 4-aminopyridine (4-AP) has shown clinical efficacy in the treatment of neurological disorders such as multiple sclerosis. The clinical usefulness of 4-AP is hampered by its ability to produce seizures. Nerispirdine, an analogue of 4-AP, is currently under clinical inve...

journal_title：Clinical and experimental pharmacology & physiology

authors： Smith C,Kongsamut S,Wang H,Ji J,Kang J,Rampe D

更新日期：2009-11-01 00:00:00

abstract：:1. The effects of volume depletion and NaHCO(3) loading on the expression of Na(+)/H(+) exchanger isoform 3 (NHE3), Na(+) : HCO(3)(-) cotransporter type 1 (NBC1) and neuronal (n) and inducible (i) isoforms of nitric oxide synthase (NOS) were determined in rat kidney. 2. Adult male Sprague-Dawley rats were used. Rats w...

journal_title：Clinical and experimental pharmacology & physiology

authors： Ma SK,Kang JS,Bae EH,Choi C,Lee J,Kim SH,Choi KC,Kim SW

更新日期：2008-03-01 00:00:00

abstract：:1. Accumulating animal and human data suggest that nitric oxide (NO) is important for both coronary and peripheral haemodynamic control and metabolic regulation during performance of exercise. 2. While still controversial, NO of endothelial origin is thought to potentiate exercise-induced hyperaemia, both in the perip...

journal_title：Clinical and experimental pharmacology & physiology

authors： Kingwell BA

更新日期：2000-04-01 00:00:00

abstract：:Chronic low back pain (LBP) has high prevalence in the adult population which is associated with enormous disability. Hence, our aim was to further characterise our LBP rat model by using immunohistological and immunohistochemical methods at an advanced stage (day 49) of the model. Male Sprague-Dawley rats were anaest...

journal_title：Clinical and experimental pharmacology & physiology

authors： Park TSW,Khan N,Kuo A,Nicholson JR,Corradini L,Smith MT

更新日期：2020-09-05 00:00:00

abstract：:1. Sulfur dioxide (SO(2) ) has recently been found to have various biological effects on the cardiovascular system. The present study was designed to explore the effects of SO(2) derivatives on the L-type calcium current (I (Ca, L) ) in isolated rat ventricular cardiomyocytes. 2. A Langendorf system was used to dissoc...

journal_title：Clinical and experimental pharmacology & physiology

authors： Zhang RY,Du JB,Sun Y,Chen S,Tsai HJ,Yuan L,Li L,Tang CS,Jin HF

更新日期：2011-07-01 00:00:00

abstract：:The authors have previously demonstrated that a low and intermittent peripheral dose of rapamycin (1 mg/kg three times/week) to rats inhibited mTORC1 signalling, but avoided the hyperlipidemia and diabetes-like syndrome associated with higher doses of rapamycin. The dosing regimen reduced food intake, body weight, adi...

journal_title：Clinical and experimental pharmacology & physiology

authors： Toklu HZ,Bruce EB,Sakarya Y,Carter CS,Morgan D,Matheny MK,Kirichenko N,Scarpace PJ,Tümer N

更新日期：2016-09-01 00:00:00