Abstract:
:1. Patients with chronic kidney disease (CKD) demonstrate a high burden of vascular disease. This vascular disease is unusual by way of a preponderance of medial calcification. Further, traditional cardiovascular risk factors fail to fully explain the high cardiovascular event rate in this population. 2. The present review examines the problem of medial calcification and arterial stiffness evident in patients with CKD and explores evidence for its existence and the potential pathological process involved. Many factors are emerging as potential culprits in this disease entity, although the specific roles of components such as fetuin-A, matrix Gla protein, osteopontin and fibroblast growth factor-23 have yet to be determined. Calcium and phosphate balance remains integral to the pathological process. 3. Pulse wave velocity has proven to be a useful tool to assess and follow arterial stiffness in CKD patients and is discussed. 4. Finally, techniques aimed at reducing or reversing arterial calcification and stiffness are discussed, with as yet no definitive answers available.
journal_name
Clin Exp Pharmacol Physioljournal_title
Clinical and experimental pharmacology & physiologyauthors
Kerr PG,Guerin APdoi
10.1111/j.1440-1681.2007.04660.xsubject
Has Abstractpub_date
2007-07-01 00:00:00pages
683-7issue
7eissn
0305-1870issn
1440-1681pii
CEP4660journal_volume
34pub_type
杂志文章,评审abstract::1. Raised intracranial pressure (ICP) is a major factor associated with morbidity and mortality in patients with severe head injury. Identifying the mechanisms responsible for raised ICP may be difficult and, as a result, treatment prescribed may be non-specific and often ineffective. 2. Research aimed at obtaining mo...
journal_title:Clinical and experimental pharmacology & physiology
pub_type: 杂志文章,评审
doi:10.1111/j.1440-1681.1998.tb02350.x
更新日期:1998-11-01 00:00:00
abstract::Painful diabetic neuropathy (PDN) is a type of peripheral neuropathic pain that develops as a consequence of prolonged hyperglycaemia-induced injury to the long nerves. Apart from pain, PDN is also characterized by morphine hyposensitivity. Intriguingly, in streptozotocin (STZ)-induced diabetic rats exhibiting marked ...
journal_title:Clinical and experimental pharmacology & physiology
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doi:10.1111/1440-1681.13091
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pub_type: 杂志文章
doi:10.1111/j.1440-1681.1977.tb02672.x
更新日期:1977-07-01 00:00:00
abstract::1. Inflammation, particularly the pro-inflammatory cytokine tumour necrosis factor (TNF), increases necrosis of skeletal muscle. Depletion of inflammatory cells, such as neutrophils, cromolyn blockade of mast cell degranulation or pharmacological blockade of TNF reduces necrosis of dystrophic myofibres in the mdx mous...
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pub_type: 杂志文章,评审
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journal_title:Clinical and experimental pharmacology & physiology
pub_type: 杂志文章
doi:10.1111/j.1440-1681.1982.tb00837.x
更新日期:1982-11-01 00:00:00
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journal_title:Clinical and experimental pharmacology & physiology
pub_type: 杂志文章
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更新日期:1994-05-01 00:00:00
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更新日期:2007-04-01 00:00:00
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更新日期:2014-08-01 00:00:00
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更新日期:2008-02-01 00:00:00
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pub_type: 杂志文章
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更新日期:2000-10-01 00:00:00
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更新日期:2010-12-01 00:00:00
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更新日期:1975-03-01 00:00:00
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