Apoptotic death in an in vitro model of neuronal oxidative stress.

Abstract:

:1. Oxidative stress is believed to be an important mediator of neuronal cell death but the precise mechanism by which this occurs is unknown. 2. We have developed an in vitro model of neuronal oxidative stress to study the pathways by which free radicals kill neurones. 3. We have shown that oxidative stress, cystine deprivation and glutathione depletion results in cell death with the morphological and biochemical features of apoptosis. 4. Neuronal apoptosis induced by oxidative stress can be inhibited by macromolecular synthesis inhibitors. 5. This in vitro model will be a valuable tool for defining the molecular targets of toxic free radicals in neurones and, in turn, in designing rational new therapies for free radical mediated diseases.

authors

Ratan RR,Baraban JM

doi

10.1111/j.1440-1681.1995.tb02006.x

subject

Has Abstract

pub_date

1995-04-01 00:00:00

pages

309-10

issue

4

eissn

0305-1870

issn

1440-1681

journal_volume

22

pub_type

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