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Inhaled therapies in patients with moderate COPD in clinical practice: current thinking.

Abstract：

:COPD is a complex, heterogeneous condition. Even in the early clinical stages, COPD carries a significant burden, with breathlessness frequently leading to a reduction in exercise capacity and changes that correlate with long-term patient outcomes and mortality. Implementation of an effective management strategy is required to reduce symptoms, preserve lung function, quality of life, and exercise capacity, and prevent exacerbations. However, current clinical practice frequently differs from published guidelines on the management of COPD. This review focuses on the current scientific evidence and expert opinion on the management of moderate COPD: the symptoms arising from moderate airflow obstruction and the burden these symptoms impose, how physical activity can improve disease outcomes, the benefits of dual bronchodilation in COPD, and the limited evidence for the benefits of inhaled corticosteroids in this disease. We emphasize the importance of maximizing bronchodilation in COPD with inhaled dual-bronchodilator treatment, enhancing patient-related outcomes, and enabling the withdrawal of inhaled corticosteroids in COPD in well-defined patient groups.

journal_name

Int J Chron Obstruct Pulmon Dis

journal_title

International journal of chronic obstructive pulmonary disease

authors

Ariel A,Altraja A,Belevskiy A,Boros PW,Danila E,Fležar M,Koblizek V,Fridlender ZG,Kostov K,Krams A,Milenkovic B,Somfay A,Tkacova R,Tudoric N,Ulmeanu R,Valipour A

doi

10.2147/COPD.S145573

subject

Has Abstract

pub_date

2017-12-21 00:00:00

pages

45-56

eissn

1176-9106

issn

1178-2005

pii

copd-13-045

journal_volume

13

pub_type

杂志文章,评审

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