Brain in flames - animal models of psychosis: utility and limitations.

Abstract:

:The neurodevelopmental hypothesis of schizophrenia posits that schizophrenia is a psychopathological condition resulting from aberrations in neurodevelopmental processes caused by a combination of environmental and genetic factors which proceed long before the onset of clinical symptoms. Many studies discuss an immunological component in the onset and progression of schizophrenia. We here review studies utilizing animal models of schizophrenia with manipulations of genetic, pharmacologic, and immunological origin. We focus on the immunological component to bridge the studies in terms of evaluation and treatment options of negative, positive, and cognitive symptoms. Throughout the review we link certain aspects of each model to the situation in human schizophrenic patients. In conclusion we suggest a combination of existing models to better represent the human situation. Moreover, we emphasize that animal models represent defined single or multiple symptoms or hallmarks of a given disease.

authors

Mattei D,Schweibold R,Wolf SA

doi

10.2147/NDT.S65564

subject

Has Abstract

pub_date

2015-05-27 00:00:00

pages

1313-29

eissn

1176-6328

issn

1178-2021

pii

ndt-11-1313

journal_volume

11

pub_type

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