Copeptin: a new predictor for severe obstructive sleep apnea.

abstract：INTRODUCTION:The seven-year experience of elective abdominal aortic aneurysm (AAA) repair of a vascular surgical unit in a teaching hospital was reviewed to determine the factors associated with in-hospital mortality. METHODS:All patients who underwent elective open repair of an AAA between July 1, 1991, and June 30, ...

journal_title：Therapeutics and clinical risk management

authors： Mackenzie S,Swan JR,D'Este C,Spigelman AD

更新日期：2005-03-01 00:00:00

abstract：Purpose:According to the WHO vancomycin-resistant Enterococcus faecium (VRE) belongs to the microorganisms for which new antibiotics are urgently needed. Depending on the type of vancomycin resistance vanA gene VRE is differentiated from vanB VRE and other types. In this retrospective analysis the results of VRE survei...

journal_title：Therapeutics and clinical risk management

authors： Borgmann S,Rieß B,Siegmund R,Werner G,Klare I

更新日期：2019-02-27 00:00:00

abstract：:Angiogenesis is an essential process in the development, growth, and metastasis of malignant tumors including lung cancer. Several angiogenesis inhibitors have been developed as potential therapies for non-small-cell lung cancer (NSCLC). Nintedanib is a small-molecule tyrosine kinase inhibitor that targets receptors f...

journal_title：Therapeutics and clinical risk management

authors： Takeda M,Okamoto I,Nakagawa K

更新日期：2015-11-16 00:00:00

abstract：BACKGROUND:Iron-deficiency anemia is the most common nutritional cause of anemia in pregnancy and is often responsible for puerperal anemia. Puerperal anemia can impair postpartum maternal and neonatal well-being. OBJECTIVE:To determine the effect of treatment of moderate puerperal iron-deficiency anemia using a singl...

journal_title：Therapeutics and clinical risk management

authors： Iyoke CA,Emegoakor FC,Ezugwu EC,Lawani LO,Ajah LO,Madu JA,Ezegwui HU,Ezugwu FO

更新日期：2017-05-17 00:00:00

abstract：:Parkinson's disease (PD) is a progressive neurodegenerative, dopamine deficiency disorder. The main therapeutic strategies for PD treatment relies on dopamine precursors (levodopa), inhibition of dopamine metabolism (monoamine oxidase [MAO] B and catechol-O-methyl transferase inhibitors), and dopamine receptor agonist...

journal_title：Therapeutics and clinical risk management

authors： Lecht S,Haroutiunian S,Hoffman A,Lazarovici P

更新日期：2007-06-01 00:00:00

abstract：:A utilization study was performed in a 2200-bed tertiary care teaching hospital. Data mining was performed on all nasogastric medication prescriptions for patients hospitalized in 2011. Nurses were interviewed by questionnaire. A PDCA (Plan-Do-Check-Act) cycle was used for continuous quality improvement. The proportio...

journal_title：Therapeutics and clinical risk management

authors： Zhu LL,Xu LC,Wang HQ,Jin JF,Wang HF,Zhou Q

更新日期：2012-01-01 00:00:00

abstract：BACKGROUND:The irradiation of head and neck cancer (HNC) often causes damage to the salivary glands. The resulting salivary gland hypofunction and xerostomia seriously reduce the patient's quality of life. PURPOSE:To analyze the literature of actual management strategies for radiation-induced hypofunction and xerostom...

journal_title：Therapeutics and clinical risk management

authors： Pinna R,Campus G,Cumbo E,Mura I,Milia E

更新日期：2015-02-04 00:00:00

abstract：:Use of non-vitamin K antagonist oral anticoagulants is spreading in the real world. Despite that, a strong need for antidotes/reversal agents is still reported by several physicians. Idarucizumab is a humanized monoclonal antibody fragment that binds specifically to dabigatran. Idarucizumab was approved in 2015 by the...

journal_title：Therapeutics and clinical risk management

authors： Proietti M,Boriani G

更新日期：2018-08-22 00:00:00

abstract：Purpose:We aimed to present our experience with total hip arthroplasty in patients with previous hip arthrodesis. Patients and methods:This was a retrospective study, in which clinical and radiological outcomes of total hip arthroplasty performed in 17 patients (mean age 54.2±8.5 years; age range 33-68 years; female t...

journal_title：Therapeutics and clinical risk management

authors： Çalbıyık M

更新日期：2018-04-11 00:00:00

abstract：:Vorapaxar (ZONTIVITY™, formerly known as SCH 530348) is a specific, orally active antagonist of the protease-activated receptor-1 (PAR-1) on platelets. It inhibits thrombin-induced platelet activation by binding to the ectodomain of PAR-1. After animal studies and Phase II studies showed that vorapaxar sufficiently in...

journal_title：Therapeutics and clinical risk management

authors： Diehl P,Bode C,Duerschmied D

更新日期：2015-08-03 00:00:00

abstract：OBJECTIVES:The significance of early ischemic changes (EIC) on computed tomography (CT) within 3 hours after stroke onset remains controversial. The semi-quantitative Alberta Stroke Program Early CT Score (ASPECTS) is found to have prognostic value in early stroke. This study assesses factors associated with the presen...

journal_title：Therapeutics and clinical risk management

authors： Thomassen L,Waje-Andreassen U,Naess H

更新日期：2008-08-01 00:00:00

abstract：:Chronic physical illness is associated with significant vulnerability for emotional disorders. Some studies suggest anxiety and depression are common comorbidities in individuals with alpha-1 antitrypsin deficiency (AATD). Many aspects of AATD contribute to quality of life impairment. Delays in diagnosis, high costs o...

journal_title：Therapeutics and clinical risk management

authors： Beiko T,Strange C

更新日期：2019-07-31 00:00:00

abstract：Background:Cardiovascular diseases (CVD) combined with Type 2 diabetes mellitus (T2DM) frequently occurred. In this study, we aimed at exploring the prognostic significance of blood neutrophil-lymphocyte ratio (NLR) in these types of patients. Patients and Methods:Between June 30, 2010 and August 30, 2017, 1454 pati...

journal_title：Therapeutics and clinical risk management

authors： Qiao S,Gao W,Guo S

更新日期：2020-05-19 00:00:00

abstract：:The purpose of this review was to test contraceptive efficacy, cycle control, tolerability, and acceptability as found in the non-comparative studies with NuvaRing((R)) by those found in the randomized trials comparing NuvaRing and combined oral contraceptives (COCs). All large non-comparative studies and all relevant...

journal_title：Therapeutics and clinical risk management

authors： Roumen FJ

更新日期：2008-04-01 00:00:00

abstract：:Premenstrual dysphoric disorder (PMDD) is a severe form of premenstrual syndrome (PMS). Pharmacologic options studied for treating severe PMS and PMDD may include selective serotonin reuptake inhibitors, anxiolytic agents, gonadotropin-releasing hormone agonists and the diuretic spironolactone. However, the use of com...

journal_title：Therapeutics and clinical risk management

authors： De Berardis D,Serroni N,Salerno RM,Ferro FM

更新日期：2007-08-01 00:00:00

abstract：:A number of drugs rely on the kidney for excretion and thus require their dose to be modified in any patients where there is renal impairment. Others are nephrotoxic and should be avoided completely in patients with renal disease. Traditionally clinicians have had to rely on serum creatinine to assess renal function b...

journal_title：Therapeutics and clinical risk management

authors： Harris K,Stribling B

更新日期：2007-10-01 00:00:00

abstract：AIM:To compare the long-term survival outcomes of radiofrequency ablation and liver resection for single very early/early stage hepatocellular carcinoma (HCC). METHODS:The Cochrane Library (Issue 3, 2015), Embase (1974 to March 15, 2015), PubMed (1950 to March 15, 2015), Web of Science (1900 to March 15, 2015), and Ch...

journal_title：Therapeutics and clinical risk management

authors： He ZX,Xiang P,Gong JP,Cheng NS,Zhang W

更新日期：2016-02-23 00:00:00

abstract：BACKGROUND:Artemether-lumefantrine (AL) has been used as a first-line treatment for uncomplicated Plasmodium falciparum malaria in Ethiopia since 2004. Antimalarial drug resistance is one of the major obstacles for malaria control and curtails the lifespan of several drugs. Thus, continued monitoring of the efficacy of...

journal_title：Therapeutics and clinical risk management

authors： Deressa T,Seid ME,Birhan W,Aleka Y,Tebeje BM

更新日期：2017-02-16 00:00:00

abstract：BACKGROUND:The aim of this open-label, randomized, parallel-group pilot study was to evaluate the efficacy of cefditoren pivoxil and levofloxacin in terms of speed of reduction in inflammatory parameters, clinical recovery, and microbiological eradication. METHODS:Forty eligible patients with acute exacerbation of chr...

journal_title：Therapeutics and clinical risk management

authors： Blasi F,Tarsia P,Mantero M,Morlacchi LC,Piffer F

更新日期：2013-01-01 00:00:00

abstract：:Antimicrobial agents are the most valuable means available for treating bacterial infections. However, the administration of therapeutic doses of antimicrobial agents to patients is a leading cause of disturbance of the normal gastrointestinal microflora. This disturbance results in diminishing the natural defense mec...

journal_title：Therapeutics and clinical risk management

authors： Rafii F,Sutherland JB,Cerniglia CE

更新日期：2008-12-01 00:00:00

abstract：BACKGROUND:Acute diarrhea is the major cause of child morbidity and mortality in low-income nations. It is the second most common cause of death among children <5 years of age globally. The indispensable role of community pharmacists is clearly observed in the prevention and treatment of diarrhea. However, there is a p...

journal_title：Therapeutics and clinical risk management

authors： Abegaz TM,Belachew SA,Abebe TB,Gebresilassie BM,Teni FS,Woldie HG

更新日期：2016-04-05 00:00:00

abstract：:Prostacyclin is an endogenous eicosanoid produced by endothelial cells; through actions on vascular smooth-muscle cells, it promotes vasodilation. Pulmonary arterial hypertension (PAH) is characterized by elevated mean pulmonary artery pressure due to a high pulmonary vascular resistance state. A relative decrease in ...

journal_title：Therapeutics and clinical risk management

authors： LeVarge BL

更新日期：2015-03-31 00:00:00

abstract：Background:Liver cirrhosis is an uncommon but not rare side effect of amiodarone-induced hepatotoxicity. Patients with hepatitis B virus and hepatitis C virus infections are at a high risk for developing liver cirrhosis. However, the relationship between this treatment and risk of liver cirrhosis in high-risk chronic h...

journal_title：Therapeutics and clinical risk management

authors： Huang CH,Lai YY,Kuo YJ,Yang SC,Chang YJ,Chang KK,Chen WK

更新日期：2019-01-10 00:00:00

abstract：INTRODUCTION:Available literature suggests that the advantage of animal-derived surfactants over first-generation synthetic agents derives from the presence of surface-active proteins and their phospholipid content. Here we summarize the results of clinical trials comparing animal-derived surfactant preparations with o...

journal_title：Therapeutics and clinical risk management

authors： Logan JW,Moya FR

更新日期：2009-02-01 00:00:00

abstract：:Mucositis pain is a major clinical problem associated with cancer treatment. Mucosal tissue injury is a dose-limiting side effect and also limits nutritional intake and oral function, resulting in weight loss and nutritional deficits for many patients. The pathophysiology of mucositis is thought to be a complex array ...

journal_title：Therapeutics and clinical risk management

authors： Harris DJ

更新日期：2006-09-01 00:00:00

abstract：BACKGROUND/PURPOSE:In-hospital mortality rate of acute ischemic stroke patients remains between 3% and 18%. For improving the quality of stroke care, we investigated the factors that contribute to the risk of in-hospital mortality in acute ischemic stroke patients. MATERIALS AND METHODS:Between January 1, 2007, and De...

journal_title：Therapeutics and clinical risk management

authors： Ong CT,Wong YS,Wu CS,Su YH

更新日期：2016-06-29 00:00:00

abstract：Background:Hyperparathyroidism is a frequent endocrine disorder with variable clinical manifestations and outcomes. We aimed to evaluate clinical presentations, management and outcomes of hyperparathyroidism. Methods:A retrospective study was conducted to include all patients presented with hyperparathyroidism between...

journal_title：Therapeutics and clinical risk management

authors： Al-Thani H,El-Matbouly M,Al-Sulaiti M,Asim M,Majzoub A,Tabeb A,El-Menyar A

更新日期：2018-07-31 00:00:00

abstract：:East Asians are prone to higher systemic exposure and increased risk of bleeding compared to other races after administration of antiplatelet agent(s). The aim of this systematic review was to compare and evaluate the appropriateness of a lower dose versus standard dose of ticagrelor in East Asians. A systematic searc...

journal_title：Therapeutics and clinical risk management

authors： Lee YJ,Kim H,Choi J,Lee BH,Lee SY

更新日期：2018-01-08 00:00:00

abstract：:Objective: Intraventricular hemorrhage (IVH) is characterized by acute onset, rapid progression, and high disability and mortality rates. In this study, we investigated the clinical effect of external ventricular drainage combined with continuous lumbar drainage in IVH treatments. Methods: 114 patients with IVH treate...

journal_title：Therapeutics and clinical risk management

authors： Xia D,Jiang X,Li Z,Jin Y,Dai Y

更新日期：2019-05-30 00:00:00

abstract：PURPOSE:To report two cases of chronic postoperative cystoid macular edema, resistant to topical therapy, treated with consecutive intravitreal injections of ketorolac tromethamine. METHODS:Four daily intravitreal injections of 500 μg/0.05 mL of ketorolac were given to each patient. Complete clinical examination and O...

journal_title：Therapeutics and clinical risk management

authors： Tsilimbaris MK,Tsika C,Kymionis GD

更新日期：2016-02-12 00:00:00