Abstract:
:Chronic physical illness is associated with significant vulnerability for emotional disorders. Some studies suggest anxiety and depression are common comorbidities in individuals with alpha-1 antitrypsin deficiency (AATD). Many aspects of AATD contribute to quality of life impairment. Delays in diagnosis, high costs of disease treatment, and inherited genetic risk add to the symptom burden of lung or liver disease to alter quality of life. Whether anxiety and depression independently contribute to quality of life impairment remains unproven. In this article, we aim to review current literature examining the impact of anxiety and depression on the quality of life of AATD-affected individuals. Multifaceted approaches may best meet the needs of a heterogeneous population and are the best future strategies to minimize these emotional impacts and assure highest quality of life possible. More research studies are needed to achieve this ambitious goal and make life of AATD-affected individuals better by minimizing the effects of anxiety and depression.
journal_name
Ther Clin Risk Managjournal_title
Therapeutics and clinical risk managementauthors
Beiko T,Strange Cdoi
10.2147/TCRM.S175369subject
Has Abstractpub_date
2019-07-31 00:00:00pages
959-964eissn
1176-6336issn
1178-203Xpii
175369journal_volume
15pub_type
杂志文章abstract:Purpose:To compare running suture (RS) and interrupted suture (IS) of vesicourethral anastomosis (VUA) during open retropubic radical prostatectomy (RRP) on early urinary continence and extravasation. Patients and Methods:Single center analysis of 211 patients who underwent RRP performed by a single surgeon during 200...
journal_title:Therapeutics and clinical risk management
pub_type: 杂志文章
doi:10.2147/TCRM.S278454
更新日期:2020-12-23 00:00:00
abstract:Background:Treatment-related problems (TRPs) may pose risks for patients if unaddressed. With the increased complexity of health care, it is important to target pharmacists' efforts to patients that are at high risk for TRPs. Objectives:The present study aimed to identify medications most commonly associated with TRPs...
journal_title:Therapeutics and clinical risk management
pub_type: 杂志文章
doi:10.2147/TCRM.S180747
更新日期:2018-11-16 00:00:00
abstract:Purpose:To investigate the influence and possible pathophysiological mechanism of pulsatile cardiopulmonary bypass (CPB) in various frequencies in pediatric patients undergoing congenital cardiac surgery. Patients and methods:Clinical data and hemodynamic parameters were collected in 80 patients who underwent congenit...
journal_title:Therapeutics and clinical risk management
pub_type: 杂志文章
doi:10.2147/TCRM.S170642
更新日期:2018-09-03 00:00:00
abstract::Purpose: This study aimed to assess the effect of intravenous dexmedetomidine (DEX) on sevoflurane EC50 for supraglottic airway device (SAD) insertion in spontaneously breathing morbidly obese patients. Patients and methods: Thirty-eight morbidly obese patients with a body mass index 40-57 kg/m2 who were scheduled for...
journal_title:Therapeutics and clinical risk management
pub_type: 杂志文章
doi:10.2147/TCRM.S199440
更新日期:2019-05-03 00:00:00
abstract:INTRODUCTION:Sepsis and septic shock are important causes of mortality in intensive care unit patients, hence early diagnosis and therapy are important in management of their treatment. The available information on sepsis patients is not enough to recommend or to discard the routine evaluation of triglyceride (TG) leve...
journal_title:Therapeutics and clinical risk management
pub_type: 杂志文章
doi:10.2147/TCRM.S57791
更新日期:2014-02-27 00:00:00
abstract::The C-MAC videolaryngoscope was evaluated for intubation in patients with predicted extremely difficult airway. The presented cases are patients with neoplasm tumors in larynx. In all cases, awake intubation using C-MAC videolaryngoscope was performed in patients breathing spontaneously, under local anaesthesia, with ...
journal_title:Therapeutics and clinical risk management
pub_type: 杂志文章
doi:10.2147/TCRM.S150536
更新日期:2018-03-14 00:00:00
abstract::Hyperphosphatemia is an inevitable consequence of end stage chronic kidney disease and is present in the majority of dialysis patients. Recent observational data has associated hyperphosphatemia with increased cardiovascular mortality among dialysis patients. Dietary restriction of phosphate and current dialysis presc...
journal_title:Therapeutics and clinical risk management
pub_type: 杂志文章
doi:10.2147/tcrm.s1555
更新日期:2008-10-01 00:00:00
abstract::Preterm birth is the major cause of perinatal morbidity and mortality in the developed world, and spontaneous preterm labor is the commonest cause of preterm birth. Interventions to treat women in spontaneous preterm labor have not reduced the incidence of preterm births but this may be due to increased risk factors, ...
journal_title:Therapeutics and clinical risk management
pub_type: 杂志文章
doi:10.2147/tcrm.s9378
更新日期:2010-04-26 00:00:00
abstract:AIM:The aim of this study was to evaluate the efficacy of, and patients' subjective responses to, periodontal ligament (PDL) anesthetic injection compared to traditional local-anesthetic infiltration injection for the nonsurgical extraction of one posterior maxillary permanent tooth. MATERIALS AND METHODS:All patients...
journal_title:Therapeutics and clinical risk management
pub_type: 杂志文章
doi:10.2147/TCRM.S143173
更新日期:2017-10-06 00:00:00
abstract:BACKGROUND:Internationally, there is a remarkable achievement in the areas of drug discovery, drug design, and clinical trials. New and efficient drug formulation techniques are widely available which have led to success in treatment of several diseases. Despite these achievements, large number of patients continue to ...
journal_title:Therapeutics and clinical risk management
pub_type: 杂志文章
doi:10.2147/TCRM.S85019
更新日期:2015-06-30 00:00:00
abstract:Objectives:International experts recently characterized interstitial pneumonia with autoimmune features (IPAF) as a provisional diagnosis for patients with interstitial lung disease who have characteristics of autoimmune disease but do not meet criteria for a specific autoimmune disease. We describe clinical characteri...
journal_title:Therapeutics and clinical risk management
pub_type: 杂志文章
doi:10.2147/TCRM.S173154
更新日期:2018-11-01 00:00:00
abstract:Purpose:We conducted this meta-analysis to evaluate the efficacy of hybrid grafts in anterior cruciate ligament reconstruction (ACLR). Methods:We performed an electronic search of the Cochrane Library, PubMed, Embase, and ScienceDirect from the inception of these databases to February 2018, based on the terms "anterio...
journal_title:Therapeutics and clinical risk management
pub_type: 杂志文章
doi:10.2147/TCRM.S187979
更新日期:2019-03-14 00:00:00
abstract::Regular blood transfusions as supportive care for patients with chronic anemia inevitably lead to iron overload as humans cannot actively remove excess iron. The cumulative effects of iron overload cause significant morbidity and mortality if not effectively treated with chelation therapy. Based on a comprehensive cli...
journal_title:Therapeutics and clinical risk management
pub_type: 杂志文章
doi:10.2147/tcrm.s5497
更新日期:2009-01-01 00:00:00
abstract::Uncontrolled asthma continues to be a problem for many patients with moderate-to-severe allergic asthma. Dupilumab, which blocks the receptors for interleukin-4 and interleukin-13, has been effective in reducing asthma exacerbations, improving forced expiratory volume in one second (FEV1), and reducing oral corticoste...
journal_title:Therapeutics and clinical risk management
pub_type: 杂志文章,评审
doi:10.2147/TCRM.S192392
更新日期:2020-03-04 00:00:00
abstract::Background: Avian AIV-H7N9 influenza progresses rapidly and has a high fatality rate. However, it lacks an early effective biomarker to predict disease severity and fatal outcomes successfully. Our study aimed to explore whether the neutrophil-to-lymphocyte ratio (NLR) taken within 24 h after admission can predict dis...
journal_title:Therapeutics and clinical risk management
pub_type: 杂志文章
doi:10.2147/TCRM.S206930
更新日期:2019-07-24 00:00:00
abstract::Soft tissue sarcomas (STSs) are a group of rare tumors accounting for less than 1% of all adult malignant tumors, a heterogeneous group of more than 50 histological subtypes. Five percent to 30% of STS patients experience local recurrence and 10%-38% present with clinically detectable metastases. Doxorubicin either al...
journal_title:Therapeutics and clinical risk management
pub_type: 杂志文章,评审
doi:10.2147/TCRM.S84789
更新日期:2016-01-13 00:00:00
abstract::Background: Endoscopic sinus surgery (ESS) has been the definitive treatment for chronic rhinosinusitis (CRS), but the complications caused perioperatively may affect patients' quality of life (QoL). This study aims to evaluate the effects of enhanced recovery after surgery (ERAS) on improving perioperative QoL in ESS...
journal_title:Therapeutics and clinical risk management
pub_type: 杂志文章
doi:10.2147/TCRM.S199630
更新日期:2019-06-04 00:00:00
abstract:Background:Cardiovascular diseases (CVD) combined with Type 2 diabetes mellitus (T2DM) frequently occurred. In this study, we aimed at exploring the prognostic significance of blood neutrophil-lymphocyte ratio (NLR) in these types of patients. Patients and Methods:Between June 30, 2010 and August 30, 2017, 1454 pati...
journal_title:Therapeutics and clinical risk management
pub_type: 杂志文章
doi:10.2147/TCRM.S244623
更新日期:2020-05-19 00:00:00
abstract::We describe the case of a 49-year-old male who presented to the emergency department with right-sided weakness and inability to speak. He was diagnosed with stroke and was admitted to Qatar Rehabilitation Institute after he was treated for the acute phase at Hamad General Hospital. As part of his management, he was st...
journal_title:Therapeutics and clinical risk management
pub_type:
doi:10.2147/TCRM.S169868
更新日期:2018-09-10 00:00:00
abstract:BACKGROUND:Acute diarrhea is the major cause of child morbidity and mortality in low-income nations. It is the second most common cause of death among children <5 years of age globally. The indispensable role of community pharmacists is clearly observed in the prevention and treatment of diarrhea. However, there is a p...
journal_title:Therapeutics and clinical risk management
pub_type: 杂志文章
doi:10.2147/TCRM.S98474
更新日期:2016-04-05 00:00:00
abstract:Purpose:According to the WHO vancomycin-resistant Enterococcus faecium (VRE) belongs to the microorganisms for which new antibiotics are urgently needed. Depending on the type of vancomycin resistance vanA gene VRE is differentiated from vanB VRE and other types. In this retrospective analysis the results of VRE survei...
journal_title:Therapeutics and clinical risk management
pub_type: 杂志文章
doi:10.2147/TCRM.S179208
更新日期:2019-02-27 00:00:00
abstract:Purpose:We aimed to present our experience with total hip arthroplasty in patients with previous hip arthrodesis. Patients and methods:This was a retrospective study, in which clinical and radiological outcomes of total hip arthroplasty performed in 17 patients (mean age 54.2±8.5 years; age range 33-68 years; female t...
journal_title:Therapeutics and clinical risk management
pub_type: 杂志文章
doi:10.2147/TCRM.S163569
更新日期:2018-04-11 00:00:00
abstract:BACKGROUND:Numerous reporting biases have been known to affect spontaneous reporting databases. The Weber effect, which constitutes a peak in adverse event (AE) reporting of a drug at the end of second year after regulatory approval followed by a continuous decline thereafter, has been considered an important bias for ...
journal_title:Therapeutics and clinical risk management
pub_type: 杂志文章
doi:10.2147/TCRM.S137144
更新日期:2017-09-11 00:00:00
abstract::Selectins mediate tethering and rolling of leukocytes to the vascular endothelium, the first adhesive step in the recruitment of immune cells to inflamed tissues. Thus, selectins play a key role in the pathogenesis of common inflammatory skin disorders such as atopic dermatitis or psoriasis. As a consequence of their ...
journal_title:Therapeutics and clinical risk management
pub_type: 杂志文章
doi:
更新日期:2005-09-01 00:00:00
abstract::Procarbazine HCl is a 'nonclassical' oral alkylating anticancer agent that was first synthesized in the late 1950s. It has been used in the treatment of many cancers, but its main use is in the treatment of Hodgkin's lymphoma and brain tumors and, to a lesser extent, Non-Hodgkin's lymphoma and primary central nervous ...
journal_title:Therapeutics and clinical risk management
pub_type: 杂志文章
doi:10.2147/tcrm.2007.3.2.213
更新日期:2007-06-01 00:00:00
abstract:INTRODUCTION:The seven-year experience of elective abdominal aortic aneurysm (AAA) repair of a vascular surgical unit in a teaching hospital was reviewed to determine the factors associated with in-hospital mortality. METHODS:All patients who underwent elective open repair of an AAA between July 1, 1991, and June 30, ...
journal_title:Therapeutics and clinical risk management
pub_type: 杂志文章
doi:10.2147/tcrm.1.1.27.53602
更新日期:2005-03-01 00:00:00
abstract::Parkinson's disease (PD) is a progressive neurodegenerative, dopamine deficiency disorder. The main therapeutic strategies for PD treatment relies on dopamine precursors (levodopa), inhibition of dopamine metabolism (monoamine oxidase [MAO] B and catechol-O-methyl transferase inhibitors), and dopamine receptor agonist...
journal_title:Therapeutics and clinical risk management
pub_type: 杂志文章
doi:
更新日期:2007-06-01 00:00:00
abstract::The topoisomerase I inhibitor topotecan is the only single-agent therapy approved for the treatment of recurrent small cell lung cancer (SCLC). Many patients with recurrent SCLC may be predisposed to treatment-related adverse events because of the presence of comorbidities such as advanced age, renal impairment, or ex...
journal_title:Therapeutics and clinical risk management
pub_type: 杂志文章
doi:
更新日期:2007-12-01 00:00:00
abstract::Poorly controlled asthma is currently treated by adding or removing asthma medication in a stepwise fashion to try and improve symptoms and maintain lung function. It is becoming apparent that asthma exacerbations are independent of asthma control and severity, and that the simple method of using rescue courses of cor...
journal_title:Therapeutics and clinical risk management
pub_type: 杂志文章
doi:
更新日期:2005-12-01 00:00:00
abstract:BACKGROUND:Influenza A H1N1 and H3N2 are two influenza waves that have been identified in past years. METHODS:Data from 77 inpatients from three tertiary hospitals were included and statistical analysis was performed in three different clusters. RESULTS:Thirty-four patients (44.2%) had respiratory distress upon admis...
journal_title:Therapeutics and clinical risk management
pub_type: 杂志文章
doi:10.2147/TCRM.S57429
更新日期:2014-02-07 00:00:00