Abstract:
OBJECTIVES:The significance of early ischemic changes (EIC) on computed tomography (CT) within 3 hours after stroke onset remains controversial. The semi-quantitative Alberta Stroke Program Early CT Score (ASPECTS) is found to have prognostic value in early stroke. This study assesses factors associated with the presence of EIC and the relation between EIC and clinical outcome. MATERIALS AND METHODS:CT scans from 61 consecutive patients receiving thrombolytic therapy were reviewed by 3 experienced stroke neurologists, assessing EIC (ASPECTS) and vascular signs (hyperdense middle cerebral artery stem and/or branches). Short-term outcome was assessed with the National Institute of Health Stroke Scale at 24 hours and long-term outcome with the modified Rankin Scale score after 3 months. RESULTS:The prevalence of EIC was 54% and the agreement between assessors was good (kappa 0.52-0.67). EIC was independently associated with younger age and absence of diabetes mellitus. Neither EIC nor vascular signs were associated with 3-months outcome. CONCLUSIONS:ASPECTS is as simple, systematic approach to assessing EIC, and the inter-observer agreement is good. Patient age and diabetes mellitus influence the presence of EIC.
journal_name
Ther Clin Risk Managjournal_title
Therapeutics and clinical risk managementauthors
Thomassen L,Waje-Andreassen U,Naess Hdoi
10.2147/tcrm.s2812subject
Has Abstractpub_date
2008-08-01 00:00:00pages
699-703issue
4eissn
1176-6336issn
1178-203Xjournal_volume
4pub_type
杂志文章abstract::Metachromatic leukodystrophy (MLD) disorder is a rare lysosomal storage disorder that leads to severe neurological symptoms and an early death. MLD occurs due to the deficiency of enzyme arylsulfatase A (ARSA) in leukocytes, and patients with MLD excrete sulfatide in their urine. In this study, the ARSA gene in 12 non...
journal_title:Therapeutics and clinical risk management
pub_type: 杂志文章
doi:10.2147/TCRM.S119967
更新日期:2017-06-16 00:00:00
abstract::Actinic keratoses (AKs) are epidermal cutaneous neoplasia observed predominantly in middle-aged and older subjects with mainly photo type I and photo type II on sun-exposed surfaces as a result of DNA damage. AKs have historically been characterized as being "precancerous"; however, now it is considered by many author...
journal_title:Therapeutics and clinical risk management
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journal_title:Therapeutics and clinical risk management
pub_type: 杂志文章
doi:10.2147/TCRM.S236498
更新日期:2020-01-09 00:00:00
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journal_title:Therapeutics and clinical risk management
pub_type: 杂志文章
doi:10.2147/TCRM.S30947
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journal_title:Therapeutics and clinical risk management
pub_type: 杂志文章
doi:
更新日期:2005-09-01 00:00:00
abstract:BACKGROUND:Narcolepsy is a lifelong, rare neurological sleep disorder characterized by chronic, excessive attacks of daytime sleepiness. This disease is often extremely incapacitating, interfering with every aspect of life, in work and social settings. OBJECTIVE:The purpose of this study is to specify the treatment co...
journal_title:Therapeutics and clinical risk management
pub_type: 杂志文章
doi:10.2147/TCRM.S119888
更新日期:2016-11-18 00:00:00
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journal_title:Therapeutics and clinical risk management
pub_type: 杂志文章
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journal_title:Therapeutics and clinical risk management
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doi:10.2147/TCRM.S206930
更新日期:2019-07-24 00:00:00
abstract:INTRODUCTION:A prospective study to evaluate the reliability of cystoscopy was performed with fluorescence (photodynamic diagnosis, PDD) compared with standard white light (WL) cystoscopy in patients with solitary carcinoma in situ (CIS), undergoing BCG treatment. MATERIALS AND METHODS:Between February 2004 and March ...
journal_title:Therapeutics and clinical risk management
pub_type: 杂志文章
doi:
更新日期:2007-12-01 00:00:00
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journal_title:Therapeutics and clinical risk management
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doi:
更新日期:2005-12-01 00:00:00
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journal_title:Therapeutics and clinical risk management
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abstract::A "Meeting on Upstream Rotavirus Vaccines and Emerging Vaccine Producers" was held at the World Health Organization in Geneva, Switzerland on March 28-30, 2006. The purpose was to discuss, evaluate, and weigh the importance of additional rotavirus vaccine candidates following the successful international licensure of ...
journal_title:Therapeutics and clinical risk management
pub_type: 杂志文章
doi:10.2147/tcrm.s821
更新日期:2008-02-01 00:00:00
abstract:Purpose:Postoperative urinary retention (POUR) is one of the most common complications following spinal anesthesia. Spinal anesthesia may influence urinary bladder function due to interruption of the micturition reflex. Urinary catheterization is the standard treatment of POUR. Urinary catheter insertion is an invasive...
journal_title:Therapeutics and clinical risk management
pub_type: 杂志文章
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更新日期:2018-09-11 00:00:00
abstract::Treatment of advanced, recurrent or persistent cervical cancer includes radiotherapy and chemotherapy. Radiation has been the primary treatment modality for locoregionally advanced cervical cancer. Concomitant systemic cisplatin chemotherapy and radiation have shown high response rates with improvements in durable rem...
journal_title:Therapeutics and clinical risk management
pub_type: 杂志文章
doi:10.2147/tcrm.s1771
更新日期:2008-02-01 00:00:00
abstract:Background:The effect of continuous positive airway pressure (CPAP) on nasal symptoms in patients with obstructive sleep apnea-hypopnea syndrome (OSAHS) remains controversial. In addition, possible mechanism(s) remains unclear. Objective:To examine whether CPAP contributes to the onset and exacerbation of allergic rhi...
journal_title:Therapeutics and clinical risk management
pub_type: 杂志文章
doi:10.2147/TCRM.S170548
更新日期:2018-08-24 00:00:00
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journal_title:Therapeutics and clinical risk management
pub_type: 杂志文章
doi:10.2147/tcrm.s1997
更新日期:2008-04-01 00:00:00
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journal_title:Therapeutics and clinical risk management
pub_type: 杂志文章
doi:10.2147/TCRM.S26893
更新日期:2012-01-01 00:00:00
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journal_title:Therapeutics and clinical risk management
pub_type:
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更新日期:2016-08-19 00:00:00
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journal_title:Therapeutics and clinical risk management
pub_type: 杂志文章
doi:10.2147/TCRM.S180747
更新日期:2018-11-16 00:00:00
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journal_title:Therapeutics and clinical risk management
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abstract:Purpose:Anastomotic leakage is a major surgical complication following esophagectomy and gastric pull-up. Specific risk factors such as celiac trunk (TC) stenosis and high calcification score of the aorta have been identified, but no data are available on their relative prognostic values. This retrospective study aimed...
journal_title:Therapeutics and clinical risk management
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journal_title:Therapeutics and clinical risk management
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journal_title:Therapeutics and clinical risk management
pub_type: 杂志文章,评审
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更新日期:2014-09-05 00:00:00
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journal_title:Therapeutics and clinical risk management
pub_type: 杂志文章
doi:10.2147/tcrm.1.1.27.53602
更新日期:2005-03-01 00:00:00
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journal_title:Therapeutics and clinical risk management
pub_type: 杂志文章
doi:10.2147/tcrm.s2838
更新日期:2008-06-01 00:00:00
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journal_title:Therapeutics and clinical risk management
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更新日期:2020-03-26 00:00:00
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journal_title:Therapeutics and clinical risk management
pub_type: 杂志文章
doi:10.2147/tcrm.s3782
更新日期:2008-10-01 00:00:00
abstract::Background: Endoscopic sinus surgery (ESS) has been the definitive treatment for chronic rhinosinusitis (CRS), but the complications caused perioperatively may affect patients' quality of life (QoL). This study aims to evaluate the effects of enhanced recovery after surgery (ERAS) on improving perioperative QoL in ESS...
journal_title:Therapeutics and clinical risk management
pub_type: 杂志文章
doi:10.2147/TCRM.S199630
更新日期:2019-06-04 00:00:00
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journal_title:Therapeutics and clinical risk management
pub_type: 杂志文章,评审
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更新日期:2015-11-16 00:00:00
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journal_title:Therapeutics and clinical risk management
pub_type: 杂志文章
doi:
更新日期:2007-06-01 00:00:00