当前位置： SCI文献检索 > DISEASES OF THE ESOPHAGUS期刊下所有文献 > Association of methylenetetrahydrofolate reductase and thymidylate synthase promoter polymorphisms with genetic susceptibility to esophageal and cardia cancer in a Chinese high-risk population.

Association of methylenetetrahydrofolate reductase and thymidylate synthase promoter polymorphisms with genetic susceptibility to esophageal and cardia cancer in a Chinese high-risk population.

Abstract：

SUMMARY:Methylenetetrahydrofolate reductase (MTHFR) and thymidylate synthase (TS) are key enzymes in folate metabolism, which is essential for normal DNA methylation and synthesis. Common polymorphisms at the MTHFR nucleotides position 677 (C-T) and a 28-bp tandem repeat polymorphism (2R or 3R) in the TS promoter enhancer region (TSER) have been reported to be functional and are supposed to disturb the normal DNA methylation and synthesis leading to carcinogenesis. To investigate the association between these polymorphisms and the risk of esophageal squamous cell carcinoma (ESCC) and gastric cardia adenocarcinoma (GCA), we conducted a case-control study in the Anyang area where the incidence of ESCC is highest in northern China. Subjects consisted of 275 cases with ESCC, 129 cases with GCA and 310 sex- and age-matched cancer-free controls. The risk was evaluated in terms of age-sex adjusted odds ratios (ORs) and 95% confidence intervals (CIs) by unconditional logistic regression model. The ORs for the MTHFR677TT genotype compared with the MTHFR677CC/CT genotype were 1.62 (95% CI = 1.15-2.30) and 1.81 (1.17-2.81) for ESCC and GCA, respectively. The ORs for the TSER 2R/2R genotype relative to the other genotypes were 2.44 (0.89-6.73) and 3.94 (1.29-12.0) for SCC and GCA, respectively. These findings indicated that the folate metabolism plays an important role in carcinogenesis of ESCC and GCA and the common functionally polymorphisms MTHFRC677T and TSER have substantial influence in this metabolic pathway.

journal_name

Dis Esophagus

journal_title

Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus

authors

Wang LD,Guo RF,Fan ZM,He X,Gao SS,Guo HQ,Matsuo K,Yin LM,Li JL

doi

10.1111/j.1442-2050.2005.00492.x

subject

Has Abstract

pub_date

2005-01-01 00:00:00

pages

177-84

issue

3

eissn

1120-8694

issn

1442-2050

pii

DES492

journal_volume

18

pub_type

杂志文章

相关文献

DISEASES OF THE ESOPHAGUS文献大全
  • The use of circular stapler for cervical esophagogastric anastomosis after esophagectomy: surgical technique and early postoperative outcome.

    abstract：:Stapled esophagogastric anastomosis after esophagectomy is considered to be superior to traditional handsewn techniques. Linear staplers are usually used. The aim of this study is to evaluate early postoperative results of circular stapler in cervical esophagogastric anastomosis. Records of all patients who underwent ...

    journal_title：Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus

    pub_type： 杂志文章

    doi：10.1111/j.1442-2050.2008.00913.x

    authors： Pines G,Buyeviz V,Machlenkin S,Klein Y,Laor A,Kashtan H

    更新日期：2009-01-01 00:00:00

  • Efficacy of chemoradiotherapy with low-dose cisplatin and continuous infusion of 5-fluorouracil for unresectable squamous cell carcinoma of the esophagus.

    abstract：:We retrospectively investigated the efficacy of a chemoradiotherapy regimen using daily low-dose cisplatin and continuous 5-fluorouracil infusion in 71 registered patients with unresectable esophageal cancer. The overall response rate (complete response plus partial response) was 59%. The major toxicities observed wer...

    journal_title：Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus

    pub_type： 杂志文章

    doi：10.1111/j.1442-2050.2008.00935.x

    authors： Takagawa R,Kunisaki C,Makino H,Kosaka T,Ono HA,Akiyama H,Shimada H

    更新日期：2009-01-01 00:00:00

  • Outcomes of definitive chemoradiation in patients with esophageal cancer.

    abstract：:The incidence of esophageal cancer has risen dramatically in the Western world. Although surgical resection of esophageal tumors is considered the cornerstone of curative approaches in localized esophageal cancer, approximately 40% of patients who undergo chemoradiation followed by surgery will experience a recurrence...

    journal_title：Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus

    pub_type： 杂志文章,评审

    doi：10.1111/dote.12506

    authors： Mikhail S,Wei L,Salem ME,Bekaii-Saab T

    更新日期：2017-02-01 00:00:00

  • Estrogen and progesterone receptors in esophageal carcinoma.

    abstract：:Information is sparse and contradictory in the literature regarding the role of estrogen receptor (ER) and progesterone receptor (PR) in esophageal carcinoma. This study was conducted over a period of 18 months from September 2004 with the primary aim of determining the PR, ER alpha (ERalpha) and ER beta (ERbeta) stat...

    journal_title：Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus

    pub_type： 杂志文章

    doi：10.1111/j.1442-2050.2007.00767.x

    authors： Kalayarasan R,Ananthakrishnan N,Kate V,Basu D

    更新日期：2008-01-01 00:00:00

  • Small volume acid reflux in gastroesophageal reflux disease patients with hiatal hernia is only detectable by pH-metry but not by multichannel intraluminal impedance.

    abstract：:Until now, it is uncertain if the so-called pH-only reflux episodes that consist of a pH drop without evidence of retrograde bolus movement in multichannel intraluminal impedance (MII) represent reflux episodes or artifacts. Hiatal hernia (HH) may allow reflux of small volumes to occur that can be detected by pH-metry...

    journal_title：Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus

    pub_type： 杂志文章

    doi：10.1111/j.1442-2050.2012.01379.x

    authors： Weigt J,Malfertheiner P

    更新日期：2013-07-01 00:00:00

  • Early diagnosis of mucosal squamous cell carcinoma of the esophagus: including two interesting cases of superficial spreading-type and multicentric-type squamous cell carcinomas.

    abstract：:We reviewed 10 patients with esophageal mucosal carcinoma in order to improve the early diagnosis of the disease. Histologically seven of the 14 lesions were carcinomas in situ (epithelial cancer), and the other seven lesions were carcinomas confined to the mucosa other than epithelial cancer (muscularis mucosae cance...

    journal_title：Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus

    pub_type： 杂志文章

    doi：10.1093/dote/10.3.201

    authors： Kimura H,Konishi K,Earashi M,Satou T,Nojima N,Inoue T,Maeda K,Yabushita K,Kuroda Y,Tsuji M,Miwa A

    更新日期：1997-07-01 00:00:00

  • Trimodality therapy and definitive chemoradiotherapy for esophageal cancer: a single-center experience and review of the literature.

    abstract：:In the UK, the standard of care for esophageal cancer has generally combined surgery with neoadjuvant chemotherapy, with definitive chemoradiotherapy (dCRT) being reserved for certain subgroups. Chemoradiotherapy followed by surgery (trimodality therapy) has not been widely adopted. The outcomes of patients undergoing...

    journal_title：Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus

    pub_type： 杂志文章,评审

    doi：10.1111/dote.12242

    authors： Hategan M,Cook N,Prewett S,Hindmarsh A,Qian W,Gilligan D

    更新日期：2015-10-01 00:00:00

  • Laparoscopic inversion esophagectomy: simplifying a daunting operation.

    abstract：:Minimally invasive esophageal resection is a technically demanding procedure that may reduce patient morbidity and improve convalescence when compared with the open approach. Despite these proposed advantages, the minimally invasive approach has not been widely embraced and is routinely performed in only a few special...

    journal_title：Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus

    pub_type： 杂志文章

    doi：10.1111/j.1442-2050.2004.00383.x

    authors： Jobe BA,Reavis KM,Davis JJ,Hunter JG

    更新日期：2004-01-01 00:00:00

  • Impedance nadir values correlate with barium bolus amount.

    abstract：:We examined the value of impedance monitoring in measuring bolus volume compared with videoesophagram. Eighty consecutive subjects were studied with simultaneous impedance-manometry-videoesophagram. A catheter with both an impedance electrode pair and a pressure transducer at four sites (5, 10, 15, 20 cm above lower e...

    journal_title：Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus

    pub_type： 杂志文章

    doi：10.1111/j.1442-2050.2011.01302.x

    authors： Imam H,Marrero F,Shay S

    更新日期：2012-09-01 00:00:00

  • Health-related quality of life in long-term survivors after high-dose chemoradiotherapy followed by surgery in esophageal cancer.

    abstract：:Curative treatment of esophageal cancer with definitive or preoperative high-dose chemoradiotherapy inflicts a major strain on the patients with potentially severe physical, emotional, and social consequences. The aim of this study was to assess various aspects of quality of life and fatigue in long-term survivors fol...

    journal_title：Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus

    pub_type： 杂志文章

    doi：10.1111/j.1442-2050.2010.01104.x

    authors： Hurmuzlu M,Aarstad HJ,Aarstad AK,Hjermstad MJ,Viste A

    更新日期：2011-01-01 00:00:00

  • Surveillance of neo-squamous epithelium after ablation of Barrett's esophagus: is it better to use jumbo over standard biopsy forceps?

    abstract：BACKGROUND AND AIMS:As obtaining adequate tissue on biopsy is critical for the detection of residual and recurrent intestinal metaplasia/dysplasia in Barrett's esophagus (BE) patients undergone Barrett's endoscopic eradication therapy (BET), we decided to compare the adequacy of biopsy specimens using jumbo versus stan...

    journal_title：Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus

    pub_type： 杂志文章

    doi：10.1093/dote/doaa044

    authors： Duvvuri A,Desai M,Srinivasan S,Chandrashekar VT,Vennelaganti S,Vennalaganti P,Jani B,Lim D,Ciscato C,Spaggiari P,Consolo P,Porter J,Ferrara E,Kennedy K,Gupta N,Mathur S,Sharma P,Repici A

    更新日期：2020-05-28 00:00:00

  • Circumferential and axial distribution of esophageal mucosal damage in reflux disease.

    abstract：:The aim of this study was to evaluate the axial and radial distribution of histological markers including hyperplasia of the basal cell layer, elongation of the papillae and dilatation of the intercellular spaces of the squamous epithelium in patients with nonerosive reflux disease compared to controls and to relate t...

    journal_title：Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus

    pub_type： 杂志文章

    doi：10.1111/j.1442-2050.2007.00678.x

    authors： Edebo A,Vieth M,Tam W,Bruno M,van Berkel AM,Stolte M,Schoeman M,Tytgat G,Dent J,Lundell L

    更新日期：2007-01-01 00:00:00

  • Heller's esophagomyotomy with or without a 360 degrees floppy Nissen fundoplication for achalasia. Long-term results from a prospective randomized study.

    abstract：:Heller's esophagomyotomy relieves dysphagia but does not restore esophageal peristalsis. The myotomy may induce reflux and the addition of a 360 degrees fundoplication may be hazardous with regard to the remaining aperistaltic esophagus. The aim of this prospectively randomized clinical trial was to compare the outcom...

    journal_title：Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1111/j.1442-2050.2003.00348.x

    authors： Falkenback D,Johansson J,Oberg S,Kjellin A,Wenner J,Zilling T,Johnsson F,Von Holstein CS,Walther B

    更新日期：2003-01-01 00:00:00

  • Implementation of guidelines in eosinophilic esophagitis at an academic pediatric practice.

    abstract：:Guidelines for eosinophilic esophagitis (EoE) require high-dose PPI (HD-PPI) trial to evaluate for PPI-responsive esophageal eosinophilia (PPI-REE) prior to EoE diagnosis and dedicated therapy. This involves a second esophagogastroduodenoscopy (EGD) to assess for PPI-REE. This study is to evaluate adherence to current...

    journal_title：Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus

    pub_type： 杂志文章

    doi：10.1093/dote/doy029

    authors： Harris BR,Hon E,Gupta SK

    更新日期：2018-08-01 00:00:00

  • Clinical benefits of a swallowing intervention for esophageal cancer patients after esophagectomy.

    abstract：:Dysphagia after esophagectomy is the main cause of a prolonged postoperative stay. The present study investigated the effects of a swallowing intervention led by a speech-language-hearing therapist (SLHT) on postoperative dysphagia. We enrolled 276 consecutive esophageal cancer patients who underwent esophagectomy and...

    journal_title：Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus

    pub_type： 杂志文章

    doi：10.1093/dote/doaa094

    authors： Takatsu J,Higaki E,Hosoi T,Yoshida M,Yamamoto M,Abe T,Shimizu Y

    更新日期：2020-10-29 00:00:00

  • Optical techniques for perfusion monitoring of the gastric tube after esophagectomy: a review of technologies and thresholds.

    abstract：:Anastomotic leakage is one of the most severe complications after esophageal resection with gastric tube reconstruction. Impaired perfusion of the gastric fundus is seen as the main contributing factor for this complication. Optical modalities show potential in recognizing compromised perfusion in real time, when isch...

    journal_title：Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus

    pub_type： 杂志文章,评审

    doi：10.1093/dote/dox161

    authors： Jansen SM,de Bruin DM,van Berge Henegouwen MI,Strackee SD,Veelo DP,van Leeuwen TG,Gisbertz SS

    更新日期：2018-06-01 00:00:00

  • Trends in diagnoses after implementation of the Chicago classification for esophageal motility disorders (V3.0) for high-resolution manometry studies.

    abstract：:To determine trends in the diagnostic distribution of esophageal motility disorders after implementation of the Chicago Classification Version 3.0 (CC V3.0) for interpretation of high-resolution manometry (HRM) studies compared to non-Chicago Classification criteria. Retrospective trends analysis of patients with an H...

    journal_title：Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus

    pub_type： 杂志文章

    doi：10.1093/dote/dox068

    authors： Laing P,Bress AP,Fang J,Peterson K,Adler DG,Gawron AJ

    更新日期：2017-12-01 00:00:00

  • Superiority of anti-reflux stent compared with conventional stents in the palliative management of patients with cancer of the lower esophagus and esophago-gastric junction: results of a randomized clinical trial.

    abstract：:Palliation of inoperable esophageal cancer with covered stents aims to relieve progressive dysphagia and improve health-related quality of life (HRQoL). Introducing a stent across the esophagogastric junction in lower third tumors may predispose to unchecked gastro-esophageal reflux (GER). Esophageal stents incorporat...

    journal_title：Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus

    pub_type： 杂志文章,随机对照试验

    doi：10.1111/j.1442-2050.2007.00696.x

    authors： Power C,Byrne PJ,Lim K,Ravi N,Moore J,Fitzgerald T,Keeling PW,Reynolds JV

    更新日期：2007-01-01 00:00:00

  • Impedance characteristics of esophageal motor function in achalasia.

    abstract：:Detailed data on patterns of esophageal bolus transport in patients with achalasia are still lacking. To study these we applied the novel technique of multichannel intraluminal impedance measurements. Ten patients with achalasia were studied using a 16 channel system. Liquid and semisolid boluses of 10 mL were applied...

    journal_title：Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus

    pub_type： 杂志文章

    doi：10.1111/j.1442-2050.2004.00372.x

    authors： Nguyen HN,Domingues GR,Winograd R,Lammert F,Silny J,Matern S

    更新日期：2004-01-01 00:00:00

  • Gastroesophageal reflux disease progressing to achalasia.

    abstract：:Two achalasia patients with former complaints of heartburn were examined. Antisecretory drugs were used by the patients when dysphagia occurred. Barium X-ray and esophageal manometry were performed and achalasia was diagnosed in both patients. Twenty-four-hour pH-metry showed significant and long-lasting acid reflux d...

    journal_title：Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus

    pub_type： 杂志文章

    doi：10.1111/j.1442-2050.2005.00515.x

    authors： Király A,Illés A,Undi S,Varga G,Kalmár K,Horváth PO

    更新日期：2005-01-01 00:00:00

  • Use of multiple channel pH monitoring for evaluation of ultra-distal reflux in patients after fundoplication for treatment of Barrett's esophagus.

    abstract：:Dysplasia and esophageal adenocarcinoma may arise in patients with Barrett's esophagus after fundoplication esophageal pH monitoring showing no acid in esophagus. This suggests the need to develop methodology to evaluate the occurrence of ultra-distal reflux (1cm above the LES). The objective of the study was to compa...

    journal_title：Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus

    pub_type： 杂志文章

    doi：10.1111/j.1442-2050.2010.01160.x

    authors： Seguro FC,Santo MA,Szachnowicz S,Maluf Filho F,Kishi HS,Falcão AM,Nasi A,Sallum RA,Cecconello I

    更新日期：2011-08-01 00:00:00

  • Association of ablation of Barrett's esophagus with high grade dysplasia and adenocarcinoma of the gastric cardia.

    abstract：:There has been increasing application of endoscopic ablation therapy for patients with high-grade dysplasia (HGD) and Barrett's esophagus (BE). Three cases are reported in which the patient developed adenocarcinoma of the gastric cardia after thermal ablation of HGD. A definition of BE including endoscopic abnormality...

    journal_title：Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus

    pub_type： 杂志文章

    doi：10.1111/j.1442-2050.2006.00577.x

    authors： Sampliner RE,Camargo E,Prasad AR

    更新日期：2006-01-01 00:00:00

  • Randomized controlled study on preoperative chemoradiotherapy followed by surgery versus surgery alone for esophageal squamous cell cancer in a single institution.

    abstract：:The purpose of the present study was to compare the clinical results between preoperative chemoradiotherapy followed by surgery (CRT group) and surgery alone (Surgery group) by a randomized controlled study. Twenty-two patients were assigned to the CRT group and 23 to the Surgery group. A total radiation dose of 40 Gy...

    journal_title：Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus

    pub_type： 杂志文章,随机对照试验

    doi：10.1111/j.1442-2050.2006.00615.x

    authors： Natsugoe S,Okumura H,Matsumoto M,Uchikado Y,Setoyama T,Yokomakura N,Ishigami S,Owaki T,Aikou T

    更新日期：2006-01-01 00:00:00

  • The natural history of gastro-esophageal reflux disease: a comprehensive review.

    abstract：:Gastroesophageal reflux disease (GERD) is a common disorder of the upper gastrointestinal tract which is typically characterized by heartburn and acid regurgitation. These symptoms are widespread in the community and range from 2.5% to more than 25%. Economic analyses showed an increase in direct and indirect costs re...

    journal_title：Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus

    pub_type： 杂志文章,评审

    doi：10.1111/dote.12511

    authors： Savarino E,de Bortoli N,De Cassan C,Della Coletta M,Bartolo O,Furnari M,Ottonello A,Marabotto E,Bodini G,Savarino V

    更新日期：2017-02-01 00:00:00

  • Small cell carcinoma of the esophagus; clinicopathological and immunohistochemical analysis of six cases.

    abstract：:Small cell carcinoma arising in the esophagus is a relatively rare disease. In the more common small cell carcinoma of the lung, the diagnostic significance of several new markers has been recently reported. This study used immunohistochemical techniques in addition to clinicopathological analysis, in order to clarify...

    journal_title：Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus

    pub_type： 杂志文章

    doi：10.1046/j.1442-2050.2003.00341.x

    authors： Noguchi T,Takeno S,Kato T,Wada S,Noguchi T,Uchida Y,Kashima K,Yokoyama S

    更新日期：2003-01-01 00:00:00

  • Comparison of bolus transit patterns identified by esophageal impedance to barium esophagram in patients with dysphagia.

    abstract：:Bolus transit through the esophagus has not been validated by videoesophagram in patients with dysphagia and changes in impedance with abnormal barium transit have not been described in those patients. The aim of this study was to compare esophageal impedance findings with barium esophagram measurements in patients wi...

    journal_title：Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus

    pub_type： 杂志文章

    doi：10.1111/j.1442-2050.2011.01212.x

    authors： Cho YK,Choi MG,Oh SN,Baik CN,Park JM,Lee IS,Kim SW,Choi KY,Chung IS

    更新日期：2012-01-01 00:00:00

  • Outcomes in achalasia from a surgical unit where pneumatic dilatation is first-line therapy.

    abstract：:The management of achalasia remains controversial, with little consensus on the optimal patient treatment pathway. In our own esophageal unit, we offer pneumatic dilatation as the initial therapy in most patients as first-line therapy. In this study, we aimed to examine the safety and efficacy of our own approach to t...

    journal_title：Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus

    pub_type： 杂志文章

    doi：10.1111/j.1442-2050.2010.01055.x

    authors： Howard JM,Mongan AM,Manning BJ,Byrne P,Lawler P,Ravi N,Reynolds JV

    更新日期：2010-08-01 00:00:00

  • Manometric study in Kearns-Sayre syndrome.

    abstract：:Although swallowing difficulties have been described in patients with Kearns-Sayre syndrome (KSS), the spectrum of manometric characteristics of dysphagia is not yet well known. Moreover, it is conceivable that a combination of various degrees of swallowing difficulties with different patterns in manometric studies ex...

    journal_title：Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus

    pub_type： 杂志文章

    doi：10.1111/j.1442-2050.2001.00152.x

    authors： Katsanos KH,Nastos D,Noussias V,Christodoulou D,Kappas A,Tsianos EV

    更新日期：2001-01-01 00:00:00

  • Patient characteristics, clinical, endoscopic, and histologic findings in adult eosinophilic esophagitis: a case series and systematic review of the medical literature.

    abstract：:The objective of our study is to describe patient characteristics, clinical, endoscopic, and pathologic features and management of adult eosinophilic esophagitis (EE). A retrospective review of adults with EE (20 or more eosinophils per high-power field) diagnosed between 1997 and 2006, and a systematic review of the ...

    journal_title：Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus

    pub_type： 杂志文章,评审

    doi：10.1111/j.1442-2050.2007.00721.x

    authors： Pasha SF,DiBaise JK,Kim HJ,De Petris G,Crowell MD,Fleischer DE,Sharma VK

    更新日期：2007-01-01 00:00:00

  • Influence of the esophageal hiatus size on the lower esophageal sphincter, on reflux activity and on symptomatology.

    abstract：:Hiatal hernia is an underlying factor contributing to gastroesophageal reflux disease (GERD). However, it remains elusive whether the size of the esophageal hiatus has a de facto influence on the lower esophageal sphincter (LES), on the intensity of patient reflux, on GERD symptoms and on the quality of life (QoL). On...

    journal_title：Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus

    pub_type： 杂志文章

    doi：10.1111/j.1442-2050.2011.01238.x

    authors： Koch OO,Kaindlstorfer A,Antoniou SA,Asche KU,Granderath FA,Pointner R

    更新日期：2012-04-01 00:00:00