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Efficacy of chemoradiotherapy with low-dose cisplatin and continuous infusion of 5-fluorouracil for unresectable squamous cell carcinoma of the esophagus.

Abstract：

:We retrospectively investigated the efficacy of a chemoradiotherapy regimen using daily low-dose cisplatin and continuous 5-fluorouracil infusion in 71 registered patients with unresectable esophageal cancer. The overall response rate (complete response plus partial response) was 59%. The major toxicities observed were leukopenia and anorexia. The 1- and 3-year overall survival rates were 54.6% and 18.4%, respectively. A low preoperative C-reactive protein level was found to be associated with a good response. The pretreatment performance status and response results were both shown to be prognostic factors for overall survival. These findings confirmed that the chemoradiotherapy regimen had curative potential for unresectable esophageal cancer.

journal_name

Dis Esophagus

journal_title

Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus

authors

Takagawa R,Kunisaki C,Makino H,Kosaka T,Ono HA,Akiyama H,Shimada H

doi

10.1111/j.1442-2050.2008.00935.x

subject

Has Abstract

pub_date

2009-01-01 00:00:00

pages

482-9

issue

6

eissn

1120-8694

issn

1442-2050

pii

DES935

journal_volume

22

pub_type

杂志文章

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