Abstract：
BACKGROUND:Hereditary fructose intolerance (HFI) is a rare genetic disorder of fructose metabolism due to aldolase B enzyme deficiency. Treatment consists of fructose, sorbitol, and sucrose (FSS)-free diet. We explore possible correlations between daily fructose traces intake and liver injury biomarkers on a long-term period, in a cohort of young patients affected by HFI. METHODS:Patients' clinical data and fructose daily intake were retrospectively collected. Correlations among fructose intake, serum alanine aminotransferase (ALT) level, carbohydrate-deficient transferrin (CDT) percentage, liver ultrasonography, genotype were analyzed. RESULTS:We included 48 patients whose mean follow-up was 10.3 ± 5.6 years and fructose intake 169 ± 145.4 mg/day. Eighteen patients had persistently high ALT level, nine had abnormal CDT profile, 45 had signs of liver steatosis. Fructose intake did not correlate with ALT level nor with steatosis severity, whereas it correlated with disialotransferrin percentage (R2 0.7, p < 0.0001) and tetrasialotransferrin/disialotransferrin ratio (R2 0.5, p = 0.0001). p.A150P homozygous patients had lower ALT values at diagnosis than p.A175D variant homozygotes cases (58 ± 55 IU/L vs. 143 ± 90 IU/L, p = 0.01). CONCLUSION:A group of HFI patients on FSS-free diet presented persistent mild hypertransaminasemia which did not correlate with fructose intake. Genotypes may influence serum liver enzyme levels. CDT profile represents a good marker to assess FSS intake.
journal_name
Nutrientsjournal_title
Nutrientsauthors
Di Dato F,Spadarella S,Puoti MG,Caprio MG,Pagliardini S,Zuppaldi C,Vallone G,Fecarotta S,Esposito G,Iorio R,Parenti G,Spagnuolo MIdoi
10.3390/nu11102397subject
Has Abstractpub_date
2019-10-07 00:00:00issue
10issn
2072-6643pii
nu11102397journal_volume
11pub_type
杂志文章相关文献
Nutrients文献大全abstract：:Genome-wide association studies (GWAS) have identified copy number variants (CNVs) associated with obesity in chromosomal regions 1p31.1, 10q11.22, 11q11, 16p12.3, and recently 1p21.1, which contains the salivary amylase gene (AMY1). Recent evidence suggests this enzyme may influence gut microbiota composition through...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu10111607
更新日期：2018-11-01 00:00:00
abstract：:Several studies have demonstrated an important association between altered lipid metabolism and the development of kidney injury because of a high-fat diet. Fructose is also closely associated with renal injury. We opted for a combination of fructose and saturated fats in a diet (DH) that is a model known to induce re...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu12061624
更新日期：2020-06-01 00:00:00
abstract：:As the population is aging rapidly, there is a strong increase in the number of individuals with chronic disease and physical limitations. The decrease in skeletal muscle mass and function (sarcopenia) and the increase in fat mass (obesity) are important contributors to the development of physical limitations, which a...
journal_title：Nutrients
pub_type： 杂志文章,评审
doi：10.3390/nu10050605
更新日期：2018-05-12 00:00:00
abstract：:Poor food literacy behaviours may contribute to food insecurity in developed countries. The aim of this research was to describe the apparent prevalence of food insecurity in adults at enrolment in a food literacy program and to examine the relationship between food insecurity and a range of independent variables. Ind...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu11020445
更新日期：2019-02-20 00:00:00
abstract：:Systemic and localized ischemia and reperfusion injury remain clinically relevant issues after organ transplantation and contribute to organ dysfunctions, among which acute kidney injury is one of the most common. An in vitro test-circuit for normothermic perfusion of porcine kidneys after warm ischemia was used to in...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu11081774
更新日期：2019-08-01 00:00:00
abstract：:Vitamin A- (retinol), vitamin B12- (haptocorrin) and vitamin D-binding proteins are the major circulatory transporters of their respective ligands; they are also constituents of the salivary proteome, the origins of which, remain unclear. The aim of this study was to explore how these proteins enter saliva and their r...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu12123838
更新日期：2020-12-16 00:00:00
abstract：:The appropriate proportions of macronutritional intake have been controversial in medical nutritional therapy for diabetes, and evidence of the effects of carbohydrate consumption on diabetes complications in prospective settings is sparse. We investigated the relationships between proportions of carbohydrate intake a...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu9020113
更新日期：2017-02-06 00:00:00
abstract：BACKGROUND:Diet might influence the risk of allergic diseases. Evidence from developing countries with high prevalence of childhood asthma is scant. METHODS:Information on wheeze, rhinitis, and eczema was collected from 3209 children aged 6-7 years in 2005, who were taking part in the International Study on Asthma and...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu7075098
更新日期：2015-06-25 00:00:00
abstract：:Colorectal cancer (CRC) is one of the most commonly occurring neoplasias in humans. The prevalence of CRC rates is still rising. Although the exact background of the disease still remains unknown, it is believed that CRC may not only be a result of environmental factors, but also genetic ones. One of the mechanisms un...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu13010200
更新日期：2021-01-11 00:00:00
abstract：:Wheat is an important cereal with a key role in human nutrition. In this study, dietary fiber (DF) and arabinoxylans of different durum (Triticum turgidum ssp. Durum L.) and bread (Triticum aestivum L.) wheat flours were analyzed in order to point out their potential nutritional and health claims allege according to t...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu12020504
更新日期：2020-02-17 00:00:00
abstract：:Consuming excessive amounts of energy as dietary fat for several days or weeks can impair glycemic control and reduce insulin sensitivity in healthy adults. However, individuals who demonstrate binge eating behavior overconsume for much shorter periods of time; the metabolic consequences of such behavior remain unknow...
journal_title：Nutrients
pub_type： 临床试验,杂志文章
doi：10.3390/nu9080818
更新日期：2017-07-29 00:00:00
abstract：:Dietary intake of vitamin A (VA) and carotenes has shown beneficial effects for decreasing the risk of some types of cancer, but findings on the risk of primary liver cancer (PLC) are inconsistent. This case-control study explored the associations between the dietary intake of VA and carotenes and the risk of PLC. We ...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu8100624
更新日期：2016-10-11 00:00:00
abstract：:The relationship between the Dietary Approaches to Stop Hypertension (DASH) diet and metabolic syndrome (MetS) in people with schizophrenia is unknown and remains to be investigated. Therefore, we have conducted a three-month parallel-group randomized controlled trial. Sixty-seven hospitalized schizophrenic patients w...
journal_title：Nutrients
pub_type： 杂志文章,随机对照试验
doi：10.3390/nu11122950
更新日期：2019-12-04 00:00:00
abstract：:Mobile technology introduces opportunity for new methods of dietary assessment. The purpose of this study was to compare the reporting accuracy of a mobile food log application and 24 h recall method to a controlled meal among a convenience sample of adults (18 years of age or older). Participants were recruited from ...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu11010199
更新日期：2019-01-19 00:00:00
abstract：:Although adequate hydration is essential for health, little attention has been paid to the effects of hydration among the generally healthy population. This narrative review presents the state of the science on the role of hydration in health in the general population, specifically in skin health, neurological functio...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu11010070
更新日期：2019-01-01 00:00:00
abstract：:Raisins are dried grapes consumed worldwide that contain beneficial components for human health. They are rich in fiber and phytochemicals such as phenolic compounds. Despite a 60% sugar content, several studies have reported health-promoting properties for raisins and this review compiles the intervention studies, as...
journal_title：Nutrients
pub_type： 杂志文章,评审
doi：10.3390/nu12010054
更新日期：2019-12-24 00:00:00
abstract：:Even though irritable bowel syndrome (IBS) has been known for more than 150 years, it still remains one of the research challenges of the 21st century. According to the current diagnostic Rome IV criteria, IBS is characterized by abdominal pain associated with defecation and/or a change in bowel habit, in the absence ...
journal_title：Nutrients
pub_type： 杂志文章,评审
doi：10.3390/nu11092162
更新日期：2019-09-09 00:00:00
abstract：:Abstract: Background: Dietary protein intake is important for health. Eggs, as a protein-rich food with characteristics that appeal to older adults, may provide opportunities for increasing protein intake. Interventions that focus on the challenges or facilitators that affect a large proportion of the population will ...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu10101409
更新日期：2018-10-02 00:00:00
abstract：:Several preventive strategies to reduce dyslipidemia have been suggested, of which dietary modification features as an important one. Dyslipidemia is a major risk factor for coronary heart disease and strategies to manage dyslipidemia have been shown to reduce the incidence of cardiovascular disease (CVD). Although th...
journal_title：Nutrients
pub_type： 杂志文章,评审
doi：10.3390/nu10040468
更新日期：2018-04-11 00:00:00
abstract：:There are a significant number of studies on cognitive restraint among individuals with varying dietary patterns. Although most research has found that vegetarians report higher levels of cognitive restraint compared to non-vegetarians, many studies have contributed inconsistent results. The aim of the current study, ...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu12072133
更新日期：2020-07-17 00:00:00
abstract：:Gestational diabetes mellitus (GDM) is one of the leading causes of offspring malformations, in which eye malformation is an important disease. It has raised demand for therapy to improve fetal outcomes. In this study, we used chick embryo to establish a GDM model to study the protective effects of proanthocyanidins o...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu7085299
更新日期：2015-08-07 00:00:00
abstract：:Mucuna pruriens (Mucuna) has been prescribed in Ayurveda for various brain ailments including 'kampavata' (tremors) or Parkinson's disease (PD). While Mucuna is a well-known natural source of levodopa (L-dopa), published studies suggest that other bioactive compounds may also be responsible for its anti-PD effects. To...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu10091139
更新日期：2018-08-22 00:00:00
abstract：:In this work, the importance of dietary carotenoids in skin health and appearance is comprehensively reviewed and discussed. References are made to their applications in health-promoting and nutricosmetic products and the important public health implications that can be derived. Attention is focused on the colourless ...
journal_title：Nutrients
pub_type： 杂志文章,评审
doi：10.3390/nu11051093
更新日期：2019-05-16 00:00:00
abstract：:To the best of our knowledge, no specific questionnaires on sports nutrition knowledge (NK) have been validated so far in Italian early adolescents. The aim of the present study was to validate a short (26-item) general and sports NK questionnaire in a group of Italian early adolescents. To this aim, the questionnaire...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu12103121
更新日期：2020-10-13 00:00:00
abstract：:Despite increased interest in promoting nutrition during pregnancy, the association between maternal dietary patterns and birth outcomes has been equivocal. We examined maternal dietary patterns during pregnancy as a determinant of offspring's birth weight-for-length (WLZ), weight-for-age (WAZ), length-for-age (LAZ), ...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu7021318
更新日期：2015-02-16 00:00:00
abstract：:Modified NUTRIC (mNUTRIC) score is a useful assessment tool to determine the risk of malnutrition in patients on mechanical ventilation (MV). We identified associations between postoperative calorie adequacy, 30-day mortality, and surgical outcomes in patients with high mNUTRIC scores. Medical records of 272 patients ...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu10111589
更新日期：2018-10-29 00:00:00
abstract：BACKGROUND:Bifidobacterium represents an important early life microbiota member. Specific bifidobacterial components, exopolysaccharides (EPS), positively modulate host responses, with purified EPS also suggested to impact microbe-microbe interactions by acting as a nutrient substrate. Thus, we determined the longitudi...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu12040948
更新日期：2020-03-29 00:00:00
abstract：:The population of older adults is growing globally. This increase has led to an accumulation of chronic illnesses, so-called age-related diseases. Diet and nutrition are considered the main drivers of the global burden of diseases, and this situation applies especially to this population segment. It relates directly t...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu11061275
更新日期：2019-06-05 00:00:00
abstract：:Dietary patterns may have a role in the prevention of functional gastrointestinal disorders (FGIDs). The current study aimed at examining the association between FGIDs and adherence to the Mediterranean diet (MD) among elementary school children (ESC), as well as high school students (HSS). In a prospective cohort stu...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu11061283
更新日期：2019-06-06 00:00:00
abstract：:Advanced glycation endproducts (AGEs) can be found in protein- and sugar-rich food products processed at high temperatures, which make up a vast amount of the Western diet. The effect of AGE-rich food products on human health is not yet clear and controversy still exists due to possible contamination of samples with e...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu10121868
更新日期：2018-12-02 00:00:00
