Abstract：
:Heart failure in older individuals is normally associated with a high body mass index and relatively low lean body mass due to, in part, a resistance to the normal anabolic effect of dietary protein. In this study we have investigated the hypothesis that consumption of a specially-formulated composition of essential amino acids (HiEAAs) can overcome anabolic resistance in individuals with heart failure and stimulate the net gain of body protein to a greater extent than a commercially popular protein-based meal replacement beverage with greater caloric but lower essential amino acid (EAA) content (LoEAA). A randomized cross-over design was used. Protein kinetics were determined using primed continuous infusions of L-(2H5)phenylalanine and L-(2H2)tyrosine in the basal state and for four hours following consumption of either beverage. Both beverages induced positive net protein balance (i.e., anabolic response). However, the anabolic response was more than two times greater with the HiEAA than the LoEAA (p < 0.001), largely through a greater suppression of protein breakdown (p < 0.001). Net protein accretion (g) was also greater in the HiEAA when data were normalized for either amino acid or caloric content (p < 0.001). We conclude that a properly formulated EAA mixture can elicit a greater anabolic response in individuals with heart failure than a protein-based meal replacement. Since heart failure is often associated with obesity, the minimal caloric value of the HiEAA formulation is advantageous.
journal_name
Nutrientsjournal_title
Nutrientsauthors
Kim IY,Park S,Smeets ETHC,Schutzler S,Azhar G,Wei JY,Ferrando AA,Wolfe RRdoi
10.3390/nu11061360subject
Has Abstractpub_date
2019-06-17 00:00:00issue
6issn
2072-6643pii
nu11061360journal_volume
11pub_type
杂志文章相关文献
Nutrients文献大全abstract：:This secondary analysis study addressed a gap of knowledge: whether perceived stress reduction created by a lifestyle intervention might serve as a mediator for reducing fat and fast food intakes in low-income overweight or obese mothers of young children. This analysis included 338 low-income overweight or obese moth...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu12123606
更新日期：2020-11-24 00:00:00
abstract：BACKGROUND:To prevent malnutrition and food aspiration in children with chronic neuromuscular problems, enteral nutrition provided by gastrostomy is recommended. Long-term follow-up data about surgical and medical complications of PEG are available, but few papers have addressed all of the issues in the same series. M...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu11071555
更新日期：2019-07-10 00:00:00
abstract：:High consumption of fructose and high-fructose corn syrup is related to the development of obesity-associated metabolic diseases, which have become the most relevant diet-induced diseases. However, the influences of a high-fructose diet on gut microbiota are still largely unknown. We therefore examined the effect of s...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu12113444
更新日期：2020-11-10 00:00:00
abstract：:The prevention or alleviation of neurodegenerative diseases, including Alzheimer's disease (AD), is a challenge for contemporary health services. The aim of this study was to review the literature on the prevention or alleviation of AD by introducing an appropriate carnitine-rich diet, dietary carnitine supplements an...
journal_title：Nutrients
pub_type： 杂志文章,评审
doi：10.3390/nu12071987
更新日期：2020-07-03 00:00:00
abstract：:Objectives: To evaluate in patients admitted for stroke: (1) The frequency of hyperglycaemia associated with enteral nutrition (EN). (2) The risk of morbidity and mortality associated with the development of this type of hyperglycaemia. METHODS:A longitudinal observational study was conducted in 115 non-diabetic pati...
journal_title：Nutrients
pub_type：
doi：10.3390/nu11050996
更新日期：2019-04-30 00:00:00
abstract：:The aim of this 12-month retrospective study was to evaluate differences in the outcomes of denosumab alone or denosumab combined with vitamin D and calcium supplementation in patients having osteoporosis (OP) with rheumatoid arthritis (RA). Patients were divided into the denosumab monotherapy group (denosumab group, ...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu9050428
更新日期：2017-04-26 00:00:00
abstract：:Individualized parenteral nutrition is the most specialized type of nutritional support in the hospital setting. The composition and prescribing patterns for parenteral nutrition have evolved due to new emerging scientific evidence. In the last few years, there has been a tendency to increase the nitrogen and lipid co...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu10081079
更新日期：2018-08-13 00:00:00
abstract：:In this study, we investigated whether (E)-5-hydroxy-7-methoxy-3-(2'-hydroxybenzyl)-4-chromanone, a homoisoflavonoid compound isolated from Portulaca oleracea L., protects INS-1 pancreatic β cells against glucotoxicity-induced apoptosis. Treatment with high glucose (30 mM) induced apoptosis in INS-1 pancreatic β cells...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu11020404
更新日期：2019-02-14 00:00:00
abstract：:Non-coeliac/non-allergic gluten/wheat sensitivity (NCG/WS) is a gluten-related disorder, the pathogenesis of which remains unclear. Recently, the involvement of an increased intestinal permeability has been recognized in the onset of this clinical condition. However, mechanisms through which it takes place are still u...
journal_title：Nutrients
pub_type： 杂志文章,评审
doi：10.3390/nu9111203
更新日期：2017-11-02 00:00:00
abstract：:After enforcement of a new food labeling law in 2016, Chile exhibits a greater offer to reduced sugar products with addition of non-nutritive sweeteners (NNS). Many of these products are consumed by children, who are at greater risk of reaching the acceptable daily intake (ADI) of these food additives. The objective o...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu12061594
更新日期：2020-05-29 00:00:00
abstract：BACKGROUND:The aim of this study was to investigate total water intake (TWI) from water, beverages and foods among Italian adults and the elderly. METHODS:Data of 2607 adults and the elderly, aged 18-75 years from the last national food consumption survey, INRAN-SCAI 2005-06, were used to evaluate the TWI. The INRAN-S...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu8110674
更新日期：2016-10-26 00:00:00
abstract：:Hypertension is affected by both genetic and dietary factors. This study aimed to examine the interaction between dietary sodium/potassium intake, sodium-potassium ratios, and FGF5 rs16998073 and link these with increased risk for developing hypertension. Using data from the Health Examinee (HEXA) Study of the Korean ...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu12072121
更新日期：2020-07-17 00:00:00
abstract：:Dietary habits in children may not only impact current health status but could also shape future, lifelong dietary choices. Dietary intake data in Singaporean children are limited. The current study aimed to define the overall diet quality of Singaporean children using an existing cross-sectional dataset and to consid...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu11112615
更新日期：2019-11-01 00:00:00
abstract：:Iron is an essential micronutrient that is involved in many functions in humans, as it plays a critical role in the growth and development of the central nervous system, among others. Premature and low birth weight infants have higher iron requirements due to increased postnatal growth compared to that of term infants...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu11051090
更新日期：2019-05-16 00:00:00
abstract：:The objective of the study was to investigate the potential association of human milk leptin concentrations with child body mass index (BMI) and BMI trajectory patterns up to two years of age among children in the Ulm SPATZ Health Study. Leptin concentration was measured in skimmed human milk by ELISA (R&D System). Ch...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu11081883
更新日期：2019-08-13 00:00:00
abstract：:The bile acid receptor, TGR5, is a key regulator of glucose homeostasis, but the mechanisms by which TGR5 signaling improves glucose regulation are incompletely defined. In particular, TGR5 has an increasingly appreciated role in liver physiology and pathobiology; however, whether TGR5 signaling within the liver contr...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu12072124
更新日期：2020-07-17 00:00:00
abstract：:Dietary assessment is important for monitoring and evaluating population intakes. Online tools can reduce the level of participant burden and the time taken to complete records, compared with other methods. The study aimed to field test an online dietary recall tool (Intake24) to test the suitability for collecting di...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu10111690
更新日期：2018-11-06 00:00:00
abstract：:Cholinergic neurons in the central nervous system play a vital role in higher brain functions, such as learning and memory. Choline is essential for the synthesis of the neurotransmitter acetylcholine by cholinergic neurons. The synthesis and metabolism of acetylcholine are important mechanisms for regulating neuronal...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu11102265
更新日期：2019-09-20 00:00:00
abstract：:The COVID-19 pandemic has disrupted many aspects of daily life. The purpose of this study was to identify how health behaviors, level of stress, financial and food security have been impacted by the pandemic among Canadian families with young children. Parents (mothers, n = 235 and fathers, n = 126) from 254 families ...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu12082352
更新日期：2020-08-07 00:00:00
abstract：:Agronomic biofortification (i.e., the application of fertilizer to elevate micronutrient concentrations in staple crops) is a recent strategy recommended for controlling Iodine Deficiency Disorders (IDDs). However, its success inevitably depends on stakeholders' appreciation and acceptance of it. By taking Northern Ug...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu10040407
更新日期：2018-03-24 00:00:00
abstract：:Polyphenols (PPs) are the naturally occurring bioactive components in fruits and vegetables, and they are the most abundant antioxidant in the human diet. Studies are suggesting that ingestion of PPs might be helpful to ameliorate metabolic syndromes that may contribute in the prevention of several chronic disorders l...
journal_title：Nutrients
pub_type： 杂志文章,评审
doi：10.3390/nu13010206
更新日期：2021-01-12 00:00:00
abstract：BACKGROUND:There is still room for further studies aimed at investigating the most widespread diets in the Mediterranean area. The objective of the study is to analyze the relation of food group intake to clinical chemical indicators of health, and also to compare the food group intake with healthy well-known diet indi...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu12103097
更新日期：2020-10-12 00:00:00
abstract：:Nutrient timing involves manipulation of nutrient consumption at specific times in and around exercise bouts in an effort to improve performance, recovery, and adaptation. Its historical perspective centered on ingestion during exercise and grew to include pre- and post-training periods. As research continued, transla...
journal_title：Nutrients
pub_type： 杂志文章,评审
doi：10.3390/nu12071948
更新日期：2020-06-30 00:00:00
abstract：:As not much is known about the prevalence and predictors of nutritional deficiencies among vegans in the Czech Republic, we evaluated whether supplement use and duration of adherence to the vegan diet are associated with the risk of cobalamin and iron deficiencies. Associations between self-reported supplementation an...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu11123019
更新日期：2019-12-10 00:00:00
abstract：:In vitro and in vivo experimental studies have shown garlic has protective effects on the aging process; however, there is no evidence that garlic consumption is associated with all-cause mortality among oldest-old individuals (≥80 years). From 1998 to 2011, 27,437 oldest-old participants (mean age: 92.9 years) were r...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu11071504
更新日期：2019-06-30 00:00:00
abstract：:Distarch phosphate is a resistant starch type 4 (RS4) containing phosphodiester cross-links within and between starch molecules. This study examined the glycemic effects of VERSAFIBE 1490™ resistant starch, a distarch phosphate derived from potato, containing 90% total dietary fiber (TDF, AOAC 991.43 method). In this ...
journal_title：Nutrients
pub_type： 杂志文章,随机对照试验
doi：10.3390/nu9030237
更新日期：2017-03-05 00:00:00
abstract：:Despite several reports on the relationship between metabolic and neurodegenerative diseases, the effect of a high-sugar diet (HSD) on brain function is still unknown. Given the crucial role of oxidative stress in the pathogenesis of these disorders, this study was the first to compare the effect of an HSD on the acti...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu12103181
更新日期：2020-10-18 00:00:00
abstract：:Oligosaccharides (OS) are commonly added to infant formulas, however, their physiological impact, particularly on adult health programming, is poorly described. In adult animals, OS modify microbiota and stimulate colonic fermentation and enteroendocrine cell (EEC) activity. Since neonatal changes in microbiota and/or...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu11091967
更新日期：2019-08-21 00:00:00
abstract：:There are a significant number of studies on cognitive restraint among individuals with varying dietary patterns. Although most research has found that vegetarians report higher levels of cognitive restraint compared to non-vegetarians, many studies have contributed inconsistent results. The aim of the current study, ...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu12072133
更新日期：2020-07-17 00:00:00
abstract：:Vitamin A- (retinol), vitamin B12- (haptocorrin) and vitamin D-binding proteins are the major circulatory transporters of their respective ligands; they are also constituents of the salivary proteome, the origins of which, remain unclear. The aim of this study was to explore how these proteins enter saliva and their r...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu12123838
更新日期：2020-12-16 00:00:00
