Abstract:
:Oncolytic viruses (OVs) preferentially target and kill cancer cells without affecting healthy cells through a multi-modal mechanism of action. While historically the direct killing activity of OVs was considered the primary mode of action, initiation or augmentation of a host antitumor immune response is now considered an essential aspect of oncolytic virotherapy. To improve oncolytic virotherapy, many studies focus on increasing virus replication and spread. In this article, we open for discussion the traditional dogma that correlates replication with the efficacy of OVs, pointing out several examples that oppose this principle.
journal_name
Oncoimmunologyjournal_title
Oncoimmunologyauthors
Davola ME,Mossman KLdoi
10.1080/2162402X.2019.1596006subject
Has Abstractpub_date
2019-03-28 00:00:00pages
e1581528issue
6eissn
2162-4011issn
2162-402Xpii
1596006journal_volume
8pub_type
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