Abstract:
:PD-1 engagement on the surface of effector T cells strongly suppresses their cytotoxic function, which constitutes a major obstacle for T cell-mediated anti-tumor activities. Surprisingly, PD-1 is strongly upregulated in T cells, engaging its ligand PD-L1 during antigen presentation. However, our recent published data may provide an explanation for this apparent contradiction.
journal_name
Oncoimmunologyjournal_title
Oncoimmunologyauthors
Karwacz K,Arce F,Bricogne C,Kochan G,Escors Ddoi
10.4161/onci.1.1.17824subject
Has Abstractpub_date
2012-01-01 00:00:00pages
86-88issue
1eissn
2162-4011issn
2162-402Xpii
2011ONCOIMM0005journal_volume
1pub_type
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