Abstract:
:Type I interferon (IFN) release by irradiated cancer cells is paramount for radiation therapy to elicit anticancer immunity. Our findings demonstrate that mitochondrial outer membrane permeabilization (MOMP) triggered by RT enables exposure of mitochondrial DNA to the cytosol, hence setting off CGAS-driven type I IFN synthesis. These data point to the existence of a therapeutically actionable mitochondrial checkpoint that restricts innate immune signaling in irradiated cancer cells.
journal_name
Oncoimmunologyjournal_title
Oncoimmunologyauthors
Yamazaki T,Galluzzi Ldoi
10.1080/2162402X.2020.1797292subject
Has Abstractpub_date
2020-07-22 00:00:00pages
1797292issue
1eissn
2162-4011issn
2162-402Xpii
1797292journal_volume
9pub_type
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