Abstract:
:Cell signals integral to the tumor microenvironment influence cancer progression. Tumor-associated myeloid cells secrete pro-tumorigenic agents including, but not limited to, the potent cytokine transforming growth factor β (TGFβ). We have discovered a network of extrinsic signals including delta-like 4 (Dll4), Notch and TGFβ, linking malignant cells and tumor-infiltrating myeloid cells, a nexus portending a clinically-relevant anticancer treatment.
journal_name
Oncoimmunologyjournal_title
Oncoimmunologyauthors
Ohnuki H,Tosato Gdoi
10.4161/onci.29029subject
Has Abstractpub_date
2014-05-23 00:00:00pages
e29029eissn
2162-4011issn
2162-402Xpii
2014ONCOIMM0122journal_volume
3pub_type
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