Abstract:
:RIG-I-like helicases (RLH) are cytosolic sensors for viral RNA inducing type I interferon production. We found that pancreatic cancer cells express functional RLH and are susceptible to RLH-induced apoptosis via intrinsic and extrinsic pathways. Tumor cells displayed features of immunogenic cell death resulting in dendritic cell activation, enhanced antigen cross-presentation and efficient tumor control in vivo.
journal_name
Oncoimmunologyjournal_title
Oncoimmunologyauthors
Schnurr M,Duewell Pdoi
10.4161/21624011.2014.955687subject
Has Abstractpub_date
2014-12-13 00:00:00pages
e955687issue
9eissn
2162-4011issn
2162-402Xpii
955687journal_volume
3pub_type
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