Abstract:
:Tumors arise and progress in immunocompetent hosts presumably by activating tolerance mechanisms critical for normal homeostasis. Host immune cells can mount anti-tumor responses by activation of Toll-like receptors (TLRs). However, emerging data suggests that molecules that negatively regulate TLRs are exploited by tumors to induce tolerance and mitigate the host immunosurveillance. Targeting these negative regulators can be a potential new immunotherapeutic strategy.
journal_name
Oncoimmunologyjournal_title
Oncoimmunologyauthors
Standiford TJ,Keshamouni VGdoi
10.4161/onci.18434subject
Has Abstractpub_date
2012-05-01 00:00:00pages
340-345issue
3eissn
2162-4011issn
2162-402Xpii
2011ONCOIMM0066journal_volume
1pub_type
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