Abstract:
:Three recent publications identified the TNF/TNR2 pathway as a new target to reduce graft-versus-host-disease through regulatory T cells activation or to potentially switch on a strong anti-leukemic effect through regulatory T cells blockade in allogeneic hematopoietic stem cell transplantation. This identified the TNF/TNR2 pathway as a swith and as a new target for immune checkpoint therapy to modulate the immune regulation in this clinical setting.
journal_name
Oncoimmunologyjournal_title
Oncoimmunologyauthors
Cohen JL,Wood KJdoi
10.1080/2162402X.2017.1373236subject
Has Abstractpub_date
2017-09-21 00:00:00pages
e1373236issue
1eissn
2162-4011issn
2162-402Xpii
1373236journal_volume
7pub_type
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