Abstract:
:Searching for biomarkers that associated with the acquired resistance of malignant cells to epidermal growth factor receptor (EGFR)-targeting monoclonal antibodies is crucial to improve the clinical benefits of these therapeutic agents. We have recently demonstrated that molecular alterations in both oncogenic and immunological pathways may be responsible for such an insensitivity. Our findings suggest that a combination of targeted anticancer agents and immunomodulatory drugs may be useful for overcoming the acquired resistance of cancer cells to EGFR-specific monoclonal antibodies.
journal_name
Oncoimmunologyjournal_title
Oncoimmunologyauthors
Garrido G,Rabasa A,Sánchez Bdoi
10.4161/onci.26904subject
Has Abstractpub_date
2013-12-01 00:00:00pages
e26904issue
12eissn
2162-4011issn
2162-402Xpii
2013ONCOIMM0304journal_volume
2pub_type
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