Abstract:
:Aberrantly glycosylated tumor antigens represent promising targets for the development of anti-cancer vaccines, yet how glycans influence immune responses is poorly understood. Recent studies have demonstrated that GalNAc-glycosylation enhances antigen uptake by dendritic cells as well as CD4+ T-cell and humoral responses, but prevents CD8+ T-cell activation. Here, we briefly discuss the relevance of glycans as candidate targets for anti-cancer vaccines.
journal_name
Oncoimmunologyjournal_title
Oncoimmunologyauthors
Madsen CB,Pedersen AE,Wandall HHdoi
10.4161/onci.23659subject
Has Abstractpub_date
2013-04-01 00:00:00pages
e23659issue
4eissn
2162-4011issn
2162-402Xpii
2013ONCOIMM0013journal_volume
2pub_type
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