Abstract:
:We identified a critical role for receptor for advanced glycation end products (RAGE) in the intratumoral accumulation of myeloid-derived suppressor cells (MDSCs) during pancreatic carcinogenesis. The absence of RAGE markedly delayed neoplasia and limited MDSC accumulation in mice expressing an oncogenic variant of Kras. In spite of MDSCs, these mice accumulated non-immunosuppressive macrophages. Thus, RAGE regulates carcinogenesis and consequent myeloid responses.
journal_name
Oncoimmunologyjournal_title
Oncoimmunologyauthors
Vernon PJ,Zeh Iii HJ,Lotze MTdoi
10.4161/onci.24184subject
Has Abstractpub_date
2013-05-01 00:00:00pages
e24184issue
5eissn
2162-4011issn
2162-402Xpii
2013ONCOIMM0051journal_volume
2pub_type
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