Abstract:
:Despite the opposite roles of Tbet and Foxp3 in the immune system as well as in tumour biology, recent studies have demonstrated the presence of of CD4+ T cells, expressing both, Tbet and Foxp3. Although Tbet+Foxp3+ T cells are currently a subject of intense research, less is known about their biological function especially in cancer. Here we found a considerable accumulation of Tbet+Foxp3+CD4+ T cells, mediated by the immunosuppressive cytokine TGFβ in the lungs of tumour bearing mice. This is in line with previous studies, demonstrating the important role of TGFβ for the immunopathogenesis of cancer. By gathering results both in murine model and in human disease, we demonstrate that, the conversion of IFNγ producing anti-tumoral T-bet+Th1 CD4+ T cells into immunosuppressive Tbet and Foxp3-PD1 co-expressing regulatory cells could represent an additional important mechanism of TGFβ-mediated blockade of anti-tumour immunity.
journal_name
Oncoimmunologyjournal_title
Oncoimmunologyauthors
Kachler K,Holzinger C,Trufa DI,Sirbu H,Finotto Sdoi
10.1080/2162402X.2018.1456612subject
Has Abstractpub_date
2018-04-25 00:00:00pages
e1456612issue
8eissn
2162-4011issn
2162-402Xpii
1456612journal_volume
7pub_type
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