Abstract:
:We have recently reported that the PD-1 and CTLA4 signaling pathways are active in both effector and regulatory T cells, causing profound immune dysfunctions in the tumor microenvironment. In line with this notion, the dual blockade of PD-1- and CTLA4-conveyed signals may exert robust therapeutic effects. Here, we discuss the mechanisms possibly underlying such a synergic interaction.
journal_name
Oncoimmunologyjournal_title
Oncoimmunologyauthors
Duraiswamy J,Freeman G,Coukos Gdoi
10.4161/onci.25912subject
Has Abstractpub_date
2013-10-01 00:00:00pages
e25912issue
10eissn
2162-4011issn
2162-402Xpii
2013ONCOIMM0199journal_volume
2pub_type
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