Abstract:
:Regulatory T cell (Treg) promote IL-17-mediated colon tumorigenesis in multiple intestinal neoplasia (Min) mice colonized with enterotoxigenic Bacteroides fragilis (ETBF). Although they retain their immunosuppressive function, mucosal Treg are instrumental to initiate ETBF-triggered IL-17 colitis by limiting the availability of IL-2 in the local microenvironment. However, the mechanisms that trigger the recruitment of the pro-carcinogenic Treg in ETBF-colonized colon remained to be elucidated.
journal_name
Oncoimmunologyjournal_title
Oncoimmunologyauthors
Geis AL,Housseau Fdoi
10.1080/2162402X.2015.1118601subject
Has Abstractpub_date
2015-12-21 00:00:00pages
e1118601issue
4eissn
2162-4011issn
2162-402Xpii
1118601journal_volume
5pub_type
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