Abstract:
:In recent years, bispecific antibodies (bsAb) have emerged as promising tools for a target-specific redirection of T cells in order to eliminate malignant cells. However, CD3-engaging constructs might also activate T regulatory cells (Tregs) present in the tumor microenvironment. Whether this has detrimental or beneficial effects for tumor therapy is still controversially discussed.
journal_name
Oncoimmunologyjournal_title
Oncoimmunologyauthors
Koristka S,Cartellieri M,Arndt C,Feldmann A,Seliger B,Ehninger G,Bachmann MPdoi
10.4161/2162402X.2014.994441subject
Has Abstractpub_date
2015-01-23 00:00:00pages
e994441issue
3eissn
2162-4011issn
2162-402Xpii
994441journal_volume
4pub_type
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