Abstract:
:Successful cancer immunotherapy is thought to require de novo priming of tumor specific CD8(+) T cells in lymphatic organs. Contrasting these beliefs, cancer therapy based on interleukin-10 (IL-10) results in tumor rejection without a requirement for T-cell trafficking from lymphatic organs. Rather, IL-10 directly activates autochthonous, tumor-resident CD8(+) T cells.
journal_name
Oncoimmunologyjournal_title
Oncoimmunologyauthors
Emmerich J,Mumm JB,Oft Mdoi
10.4161/onci.21683subject
Has Abstractpub_date
2012-12-01 00:00:00pages
1637-1639issue
9eissn
2162-4011issn
2162-402Xpii
2012ONCOIMM0254journal_volume
1pub_type
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