Abstract:
:DNA damage responses have been proposed as a gatekeeper to block tumorigenesis. We identify unexpected mechanisms whereby ATM-mediated pathway interacts with NFκB inflammatory cascades, leading to upregulation of integrin-αbβ3 on chemoresistant tumor cells. The integrin-αbβ3 is responsible for impeding tumor-specific immune responses, linking chemoresistant niche with tumor immune evasion.
journal_name
Oncoimmunologyjournal_title
Oncoimmunologyauthors
Jinushi Mdoi
10.4161/onci.19123subject
Has Abstractpub_date
2012-05-01 00:00:00pages
400-402issue
3eissn
2162-4011issn
2162-402Xpii
2011ONCOIMM0109journal_volume
1pub_type
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