Abstract:
INTRODUCTION:WHO recommends the introduction of at least one single dose of inactivated polio vaccine (IPV) in routine immunisation schedules. Thus, there has been an increased demand and concurrent supply shortages of IPV worldwide. One of the strategies to improve access is the use of fractional instead of full doses of IPV. We aim to compare the effects of fractional with standard doses of IPV. METHODS AND ANALYSIS:We will include randomised trials, non-randomised trials, case-control studies and cohort studies that compared fractional with full doses of IPV among children aged 5 years or younger. We will search for eligible studies among published and grey literature. Two authors will independently screen the results of the search, select studies, extract data and assess risk of bias. We will stratify analyses by study design, type of poliovirus, type of outcome measure and number of IPV doses given. For each type of poliovirus, we will pool the outcome data from studies using random-effects meta-analyses. Statistical heterogeneity will be assessed using the χ2 test of homogeneity and quantified using the I2 statistic. To investigate statistical heterogeneity, subgroup analyses will be performed based on the timing of the first fractional dose, age of administration, immunisation schedules and country income status. Sensitivity analyses will be used to assess if the effect of IPV fractional dosing is affected by study design, risk of bias and methods of meta-analysis. ETHICS AND DISSEMINATION:We obtained approval from the University of Cape Town Human Research Ethics Committee (HREC REF: 412/2018). The findings of this review will provide evidence for decision-making with regards to IPV dosage, eventually improving access to the vaccine by stretching vaccine supplies. The results will be published in the University of Cape Town online library and in a peer reviewed journal. PROSPERO REGISTRATION NUMBER:CRD42018092647.
journal_name
BMJ Openjournal_title
BMJ openauthors
Mashunye TR,Ndwandwe DE,Dube KR,Shey M,Shelton M,Wiysonge CSdoi
10.1136/bmjopen-2018-023308subject
Has Abstractpub_date
2019-03-09 00:00:00pages
e023308issue
3issn
2044-6055pii
bmjopen-2018-023308journal_volume
9pub_type
杂志文章相关文献
BMJ Open文献大全abstract:OBJECTIVES:To investigate the accuracy, reproducibility and costs of different laboratory assays for the monitoring of unfractionated heparin (UFH) in clinical practice and to study test utilisation in Switzerland. DESIGN:Prospective evaluation study and survey among Swiss hospitals and laboratories. SETTING:Secondar...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2018-022943
更新日期:2018-06-09 00:00:00
abstract:INTRODUCTION:Acute pancreatitis (AP) is a life-threatening inflammatory disease of the exocrine pancreas which needs acute hospitalisation. Despite its importance, we have significant lack of knowledge whether the lifestyle factors elevate or decrease the risk of AP or influence the disease outcome. So far, no syntheti...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2019-029660
更新日期:2020-01-06 00:00:00
abstract:OBJECTIVES:To describe the effect of in utero exposure to the buprenorphine+naloxone combination product in a rural and remote population. SETTING:A district hospital that services rural and remote, fly-in communities in Northwestern Ontario, Canada. PARTICIPANTS:A retrospective cohort study was conducted of 855 moth...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2016-011774
更新日期:2016-10-31 00:00:00
abstract:BACKGROUND:Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a condition characterised by severe and persistent fatigue, neurological disturbances, autonomic and endocrine dysfunctions and sleep difficulties that have a pronounced and significant impact on individuals' lives. Current National Institute for...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2012-001079
更新日期:2012-11-19 00:00:00
abstract:INTRODUCTION:People living with and beyond cancer are vulnerable to a number of physical, functional and psychological issues. Undertaking a holistic needs assessment (HNA) is one way to support a structured discussion of patients' needs within a clinical consultation. However, there is little evidence on how HNA impac...
journal_title:BMJ open
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1136/bmjopen-2014-006840
更新日期:2015-05-11 00:00:00
abstract:OBJECTIVES:This study aimed to assess the knowledge of risk factors and warning symptoms and attitude towards gastric cancer screening among the general population in China. SETTING:Hunan province, China PARTICIPANTS: Individuals aged older than 18 years were recruited using a cluster sampling method. DESIGN:A cross-...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2019-029638
更新日期:2019-07-23 00:00:00
abstract:OBJECTIVE:To estimate the costs and outcomes associated with treating non-asthmatic adults (nor suffering from other lung-disease) presenting to primary care with acute lower respiratory tract infection (ALRTI) with oral corticosteroids compared with placebo. DESIGN:Cost-consequence analysis alongside a randomised con...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2019-033567
更新日期:2020-02-18 00:00:00
abstract:OBJECTIVES:Many cancer patients experience high levels of anxiety and concern during radiotherapy, often with long-lasting effects on their well-being. This systematic review aims to describe and determine the effectiveness of communication skills training (CST) for the radiotherapy team (RT) to improve conversations i...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2018-025420
更新日期:2019-04-20 00:00:00
abstract:INTRODUCTION:Opioid use patterns of individuals with non-cancer pain are influenced by the behavioural dynamics of the individual in managing and properly following the prescription. The use of assessment tools for measuring the risk of behaviour suggestive of opioid abuse is important for health professionals who prov...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2018-021948
更新日期:2018-10-02 00:00:00
abstract:INTRODUCTION:The recent introduction of incision-less lesional neurosurgery using Gamma Knife and MRI-guided focused ultrasound has revived interest in lesional treatment options for tremor disorders. Preliminary literature researches reveal that the consistency of treatment effects after lesional neurosurgery for trem...
journal_title:BMJ open
pub_type: 杂志文章,meta分析
doi:10.1136/bmjopen-2016-015409
更新日期:2017-05-09 00:00:00
abstract:OBJECTIVE:To identify, summarise and synthesise available literature on the effectiveness of implementation strategies for optimising implementation of complex interventions in primary care. DESIGN:Systematic review of reviews. DATA SOURCES:MEDLINE, EMBASE, CINAHL, Cochrane Library and PsychINFO were searched, from f...
journal_title:BMJ open
pub_type: 杂志文章,评审
doi:10.1136/bmjopen-2015-009993
更新日期:2015-12-23 00:00:00
abstract:OBJECTIVES:Several ABILHAND Rasch-built manual ability scales were previously developed for chronic stroke (CS), cerebral palsy (CP), rheumatoid arthritis (RA), systemic sclerosis (SSc) and neuromuscular disorders (NMD). The present study aimed to explore the applicability of a generic manual ability scale unbiased by ...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2012-001807
更新日期:2012-10-31 00:00:00
abstract:OBJECTIVE:The objective of the study was to investigate the symptoms people with diabetes experience when having a myocardial infarction (MI), their illness narrative and how they present their symptoms to the health service. SETTING:Three London (UK) hospitals (coronary care units and medical wards). PARTICIPANTS:Pa...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2016-015736
更新日期:2017-09-15 00:00:00
abstract:OBJECTIVE:To explore nursing students' interprofessional educational (IPE) experiences during their most recent clinical rotation and to explore the factors supporting IPE experiences. DESIGN:National cross-sectional study on data collected in 2016. SETTING:95 Bachelor of Nursing Sciences programmes; 27 Italian Unive...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2018-025575
更新日期:2019-03-20 00:00:00
abstract:OBJECTIVE:To explore the perspectives of primary healthcare (PHC) professionals providing care to refugees through mainstream general practice. DESIGN:Qualitative exploratory design with semistructured interviews subjected to inductive thematic analysis. SETTING AND PARTICIPANTS:Nine general practices enrolled in the...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2019-034323
更新日期:2019-12-31 00:00:00
abstract:OBJECTIVES:In the USA, there is little systematic evidence about the real-world trajectories of patient medical care after hospice enrolment. The objective of this study was to analyse predictors of the length of stay for hospice patients who were admitted to hospital in a retrospective analysis of the mandatorily repo...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2014-005196
更新日期:2014-07-22 00:00:00
abstract:INTRODUCTION:Persistent infection with sexually transmitted, high-risk human papillomavirus (HPV) types is the cause of all cervical cancers and some anogenital and oropharyngeal cancers. HPV is an extremely common asymptomatic infection but little known and poorly understood by the public. Patients with HPV-related ca...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2016-011205
更新日期:2016-04-25 00:00:00
abstract:INTRODUCTION:Transition between health services is widely recognised as a problematic hurdle. Yet, the factors necessary for successful transition out of child and adolescent mental health services (CAMHS) as youth reach the service boundary at age 18 are poorly understood. Further, fragmentation and variability among ...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2019-035744
更新日期:2020-02-12 00:00:00
abstract:INTRODUCTION:Idiopathic Environmental Intolerance (IEI) attributed to electromagnetic fields (EMF) refers to self-reported sensitivity mainly characterised by the attribution of non-specific physical symptoms to low-level EMF exposure emitted from sources such as mobile phones. Scientific studies have not provided evid...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2013-002933
更新日期:2013-08-29 00:00:00
abstract:INTRODUCTION:Dextro-transposition of the great arteries (d-TGA) is a life-threatening congenital health defect that requires rapid surgery. The most widely used approach is the arterial switch operation (ASO) developed by Jatene in the 1970s. The first set of children who received this intervention are now adults. The ...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2014-005123
更新日期:2014-06-11 00:00:00
abstract:INTRODUCTION:Gut microbiome and diet may be important in irritable bowel syndrome (IBS), inflammatory bowel disease (IBD) and comorbid psychiatric conditions, but the mechanisms are unclear. We will create a large cohort of patients with IBS, IBD and healthy controls, and follow them over time, collecting dietary and m...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2020-041733
更新日期:2020-10-21 00:00:00
abstract:OBJECTIVES:To conduct a fully independent, external validation of a research study based on one electronic health record database using a different database sampling from the same population. DESIGN:Retrospective cohort analysis of β-blocker therapy and all-cause mortality in patients with cancer. SETTING:Two UK nati...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2014-007299
更新日期:2015-04-13 00:00:00
abstract:OBJECTIVES:We conducted a systematic survey of the methodological literature to identify recommended approaches for how and what randomised clinical trial (RCT) authors should report on missing participant data and, on the basis of these approaches, to propose guidance for RCT authors. METHODS:We defined missing parti...
journal_title:BMJ open
pub_type: 杂志文章,评审
doi:10.1136/bmjopen-2015-008431
更新日期:2015-12-30 00:00:00
abstract:INTRODUCTION:Metabolic disorder and high blood pressure are common complications globally, and specifically among people living with HIV (PLHIV). Diabetes, metabolic syndrome and hypertension are major risk factors for cardiovascular diseases and their related complications. However, the burden of metabolic syndrome, d...
journal_title:BMJ open
pub_type: 杂志文章,meta分析
doi:10.1136/bmjopen-2017-016602
更新日期:2017-07-09 00:00:00
abstract:OBJECTIVE:To summarise the unfolding of the COVID-19 epidemic among slum dwellers and different social strata in the city of Buenos Aires during the first 20 weeks after the first reported case. DESIGN:Observational study using a time-series analysis. Natural experiment in a big city. SETTING:Population of the city o...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2020-044592
更新日期:2021-01-20 00:00:00
abstract:OBJECTIVES:Our aim was to explore how members of community pharmacy staff perceive and experience the role of procedures within the workplace in community pharmacies. SETTING:Community pharmacies in England and Wales. PARTICIPANTS:24 community pharmacy staff including pharmacists and pharmacy support staff were inter...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2015-010851
更新日期:2016-06-06 00:00:00
abstract:OBJECTIVES:Low-income and middle-income countries are undergoing epidemiological transition, however, progression is varied. Bangladesh is simultaneously experiencing continuing burden of communicable diseases and emerging burden of non-communicable diseases (NCDs). For effective use of limited resources, an increased ...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2018-026722
更新日期:2019-10-28 00:00:00
abstract:INTRODUCTION:This study aims to explore the prospective association between the dietary quality (DQ) of preschoolers and their health status in Hong Kong, with the body mass index as the main outcome variable. METHODS AND ANALYSIS:This prospective cohort study has recruited 3539 children aged between 2 and 4 years old...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2017-018380
更新日期:2017-11-08 00:00:00
abstract:OBJECTIVES:This study aims to identify the sources of funding for investigator-initiated clinical trials (IICTs) in Portugal, and to recommend ways to improve the quality of information collected from clinical trial databases about funding. DESIGN AND METHODS:A systematic search of trial registrations over the last 13...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2018-023394
更新日期:2019-05-14 00:00:00
abstract:OBJECTIVE:This study sought to assess knowledge of schizophrenia and help-seeking behaviour among undergraduate students of a Nigerian university. Sociodemographic predictors of correct recognition were also explored. DESIGN:The study was a cross-sectional descriptive survey. SETTING:The study was carried out at the ...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2019-028913
更新日期:2019-09-12 00:00:00