Abstract:
INTRODUCTION:Gut microbiome and diet may be important in irritable bowel syndrome (IBS), inflammatory bowel disease (IBD) and comorbid psychiatric conditions, but the mechanisms are unclear. We will create a large cohort of patients with IBS, IBD and healthy controls, and follow them over time, collecting dietary and mental health information and biological samples, to assess their gastrointestinal (GI) and psychological symptoms in association with their diet, gut microbiome and metabolome. METHODS AND ANALYSIS:This 5-year observational prospective cohort study is recruiting 8000 participants from 15 Canadian centres. Persons with IBS who are 13 years of age and older or IBD ≥5 years will be recruited. Healthy controls will be recruited from the general public and from friends or relatives of those with IBD or IBS who do not have GI symptoms. Participants answer surveys and provide blood, urine and stool samples annually. Surveys assess disease activity, quality of life, physical pain, lifestyle factors, psychological status and diet. The main outcomes evaluated will be the association between the diet, inflammatory, genetic, microbiome and metabolomic profiles in those with IBD and IBS compared with healthy controls using multivariate logistic regression. We will also compare these profiles in those with active versus quiescent disease and those with and without psychological comorbidity. ETHICS AND DISSEMINATION:Approval has been obtained from the institutional review boards of all centres taking part in the study. We will develop evidence-based knowledge translation initiatives for patients, clinicians and policymakers to disseminate results to relevant stakeholders.Trial registration number: NCT03131414.
journal_name
BMJ Openjournal_title
BMJ openauthors
Moayyedi P,MacQueen G,Bernstein CN,Vanner S,Bercik P,Madsen KL,Surette M,Rioux JD,Dieleman LA,Verdú E,de Souza RJ,Otley A,Targownik L,Lavis J,Cunningham J,Marshall DA,Zelinsky S,Fernandes Adoi
10.1136/bmjopen-2020-041733subject
Has Abstractpub_date
2020-10-21 00:00:00pages
e041733issue
10issn
2044-6055pii
bmjopen-2020-041733journal_volume
10pub_type
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