Abstract:
BACKGROUND:Ov16 serology is considered a reference method for Onchocerca volvulus epidemiological mapping. Given the suboptimal sensitivity of this test and the fact that seroconversion takes more than a year after infection, additional serological tests might be needed to guide onchocerciasis elimination programmes. Recently, two linear epitopes encoded in OvMP-1 and OvMP-23 peptides were introduced as serological markers, but the observed antibody cross-reactivity in samples originating from Onchocerca volvulus non-endemic areas required further investigation. METHODS:We evaluated both peptide markers in an O. volvulus hypo-endemic setting in Jimma Town, Ethiopia using peptide ELISA. For all individuals (n = 303), the infection status with soil-transmitted helminths and Schistosoma mansoni was known. RESULTS:We found that 11 (3.6%) individuals were positive for anti-Ov16 IgG4 antibodies, while 34 (11.2%) and 15 (5.0%) individuals were positive for OvMP-1 and OvMP-23, respectively. Out of the 34 OvMP-1 positive samples, 33 were negative on the Ov16 IgG4 ELISA. Similarly, out of the 15 OvMP-23 positive samples, 14 scored negative on this reference method. No difference in seroprevalence for all three markers could be observed between uninfected individuals and individuals infected with different soil-transmitted helminths or S. mansoni. Moreover, the intensity of the response to OvMP-1, OvMP-23 or Ov16 was not significantly stronger in individuals carrying patent STH or S. mansoni infections, nor was there any correlation between the intensities of the responses to the three different antigens. CONCLUSIONS:This study demonstrates that a patent infection with either soil-transmitted helminths or S. mansoni does not lead to increased antibody recognition of both OvMP-1 and OvMP23.
journal_name
Parasit Vectorsjournal_title
Parasites & vectorsauthors
Vlaminck J,Lagatie O,Verheyen A,Dana D,Van Dorst B,Mekonnen Z,Levecke B,Stuyver LJdoi
10.1186/s13071-019-3308-zsubject
Has Abstractpub_date
2019-01-28 00:00:00pages
63issue
1issn
1756-3305pii
10.1186/s13071-019-3308-zjournal_volume
12pub_type
杂志文章abstract:BACKGROUND:Novel transgenic mosquito control methods require progressively more realistic evaluation. The goal of this study was to determine the effect of a transgene that causes a male-bias sex ratio on Anopheles gambiae target populations in large insectary cages. METHODS:Life history characteristics of Anopheles g...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-019-3289-y
更新日期:2019-02-06 00:00:00
abstract:BACKGROUND:The World Health Organization (WHO) has set elimination (interruption of transmission) as an end goal for schistosomiasis. However, there is currently little guidance on the monitoring and evaluation strategy required once very low prevalence levels have been reached to determine whether elimination or resur...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-019-3611-8
更新日期:2019-09-16 00:00:00
abstract:BACKGROUND:Dicistroviridae is a new family of small, non-enveloped, +ssRNA viruses pathogenic to both beneficial arthropods and insect pests. Little is known about the dicistrovirus replication mechanism or gene function, and any knowledge on these subjects comes mainly from comparisons with mammalian viruses from the ...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/1756-3305-6-66
更新日期:2013-03-15 00:00:00
abstract:BACKGROUND:Toxocara canis is quite closely related to Ascaris suum but its biology is more complex, involving a phase of arrested development (diapause or hypobiosis) in tissues as well as transplacental and transmammary transmission routes. In the present study, we explored and compared dauer-like signalling pathways ...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-018-3265-y
更新日期:2019-01-14 00:00:00
abstract:BACKGROUND:Cryptosporidiosis is a gastrointestinal disease affecting many people worldwide. Disease incidence is often unknown and surveillance of human cryptosporidiosis is installed in only a handful of developed countries. A genetic marker that mirrors disease incidence is potentially a powerful tool for monitoring ...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-015-0921-3
更新日期:2015-06-06 00:00:00
abstract:BACKGROUND:Intestinal schistosomiasis due to Schistosoma mansoni was mapped in Cameroon in the 1990s and preventive chemotherapy launched since 2005. A situation analysis conducted in 2011 revealed an increase in schistosomiasis transmission, especially in the equatorial part of the country, despite the fact that Biomp...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-018-2763-2
更新日期:2018-03-13 00:00:00
abstract:BACKGROUND:Cytauxzoonosis is an emerging tick-borne disease of domestic and wild felids. Cytauxzoon felis induces severe and often fatal disease in domestic cats. In Europe, clinical and subclinical infections caused by Cytauxzoon sp. are described. We report the first cases of Cytauxzoon sp. infection in domestic cats...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-018-2728-5
更新日期:2018-05-10 00:00:00
abstract:BACKGROUND:The aim of this study was to determine exposure to vector-borne pathogens (VBPs) in populations of dogs living on Greek islands in the Ionian and Aegean seas. METHODS:In total, 1154 dogs with different lifestyles and of varying ages and breeds were randomly sampled and examined for the presence of clinical ...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-020-04153-8
更新日期:2020-06-03 00:00:00
abstract:BACKGROUND:Widespread deforestation occurring in the tropics is hypothesized to impact the transmission of vector-borne diseases (VBD). Predicting how environmental changes will impact VBD transmission is dependent on understanding the ecology and behaviour of potential vector species outside of domestic settings. Howe...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-018-2926-1
更新日期:2018-06-14 00:00:00
abstract:BACKGROUND:With field releases starting in Brazil, particular interest must be given to understanding how the endosymbiotic bacterium Wolbachia pipientis affects Aedes aegypti mosquitoes with a Brazilian genetic background. Currently, there is limited information on how the bacterium affects phenotypic traits such as l...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-016-1559-5
更新日期:2016-05-16 00:00:00
abstract:BACKGROUND:In the past, immune responses to several Brugia malayi immunodominant antigens have been characterized in filaria-infected populations; however, little is known regarding Wolbachia proteins. We earlier cloned and characterized few B. malayi (trehalose-6-phosphate phosphatase, Bm-TPP and heavy chain myosin, B...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-016-1963-x
更新日期:2017-01-24 00:00:00
abstract:BACKGROUND:Tick cell lines are now available from fifteen ixodid and argasid species of medical and veterinary importance. However, some tick cell lines can be difficult to cryopreserve, and improved protocols for short- and long-term low temperature storage will greatly enhance their use as tools in tick and tick-born...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/1756-3305-3-37
更新日期:2010-04-13 00:00:00
abstract:BACKGROUND:Bravecto™ Chewable Tablets for Dogs, containing fluralaner as active ingredient, is an innovative treatment for flea and tick infestations that provides safe, rapid and long acting efficacy after a single oral administration in dogs. Topically applied fluralaner provides similar safe, rapid and long acting e...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-016-1564-8
更新日期:2016-05-31 00:00:00
abstract:BACKGROUND:Culicoides biting midges are biological vectors of arboviruses including bluetongue virus (BTV), Schmallenberg virus (SBV) and African horse sickness virus (AHSV). Zoos are home to a wide range of 'at risk' exotic and native species of animals. These animals have a high value both in monetary terms, conserva...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-020-04018-0
更新日期:2020-03-16 00:00:00
abstract:BACKGROUND:The G subfamily of ABC (ATP-binding cassette) transporters of Leishmania include 6 genes (ABCG1-G6), some with relevant biological functions associated with drug resistance and phospholipid transport. Several studies have shown that Leishmania LABCG2 transporter plays a role in the exposure of phosphatidylse...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-017-2198-1
更新日期:2017-05-30 00:00:00
abstract:BACKGROUND:Schistosoma japonicum is one of the major causative agents of schistosomiasis. The pairing of males and females leads to female sexual maturation and maintains this mature state. However, the mechanisms by which pairing facilitates sexual maturation are yet to be investigated. METHODS:Parasites isolated fro...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/1756-3305-7-177
更新日期:2014-04-10 00:00:00
abstract:BACKGROUND:The emergence and spread of insecticide resistance in the major African malaria vectors Anopheles gambiae (s.s.) and An. arabiensis may compromise the current vector control interventions and threatens the global malaria control and elimination efforts. METHODS:Insecticide resistance was monitored in severa...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-017-2342-y
更新日期:2017-09-02 00:00:00
abstract:BACKGROUND:Culicoides biting midges are incriminated as biological vectors of a number of viruses, e.g. bluetongue virus. In order to define vector-free periods/areas and to assess the vectorial role of the various Culicoides species, a comprehensive knowledge on their spatio-temporal occurrence is required. METHODS:B...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/1756-3305-5-246
更新日期:2012-10-31 00:00:00
abstract:BACKGROUND:Leishmania infantum is a vector-borne pathogen endemic in countries in the Mediterranean basin, including Italy. Dogs act as the primary reservoir for this parasite, but other animal species may also be infected. Low-to-moderate seroprevalence levels of infection have been reported in apparent healthy equine...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-020-04385-8
更新日期:2020-10-22 00:00:00
abstract:BACKGROUND:Toxoplasma gondii is an intracellular protozoan parasite that infects a wide variety of warm-blooded hosts, including humans. Limited information about T. gondii infection in bats is available in China. The objective of the present study was to determine prevalence and genetic characterization of T. gondii i...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-014-0558-7
更新日期:2014-12-03 00:00:00
abstract:BACKGROUND:The merozoite of the zoonotic Plasmodium knowlesi invades human erythrocytes via the binding of its Duffy binding protein (PkDBPαII) to the Duffy antigen on the eythrocytes. The Duffy antigen has two immunologically distinct forms, Fya and Fyb. In this study, the erythrocyte-binding assay was used to quantit...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-018-3118-8
更新日期:2018-09-26 00:00:00
abstract:BACKGROUND:The emergence and massive spread of bluetongue in Western Europe during 2006-2008 had disastrous consequences for sheep and cattle production and confirmed the ability of Palaearctic Culicoides (Diptera: Ceratopogonidae) to transmit the virus. Some aspects of Culicoides ecology, especially host-seeking and f...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/1756-3305-4-119
更新日期:2011-06-27 00:00:00
abstract:BACKGROUND:Schistosomiasis is a prevalent but neglected tropical disease caused by parasitic trematodes of the genus Schistosoma, with the primary disease-causing species being S. haematobium, S. mansoni and S. japonicum. Male-female pairing of schistosomes is necessary for sexual maturity and the production of a large...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-019-3672-8
更新日期:2019-08-23 00:00:00
abstract:BACKGROUND:The myxosporean Myxidium giardi Cépède, 1906 was described infecting the kidney of the European eel, Anguilla anguilla (L.), having spindle-shaped myxospores and terminal sub-spherical polar capsules. Since then, numerous anguillid eels globally have been documented to have similar Myxidium infections. Many ...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-018-3087-y
更新日期:2018-10-22 00:00:00
abstract:BACKGROUND:Trypanosomosis is a haemoprotozoan disease, mostly transmitted by the tsetse fly (Glossina spp.), it causes severe disease in humans and animals in Sub-Saharan Africa (SSA). The disease results in loss of livestock and agricultural productivity with severe socio-economic impacts. In Ethiopia, bovine trypanos...
journal_title:Parasites & vectors
pub_type: 杂志文章,meta分析
doi:10.1186/s13071-016-1404-x
更新日期:2016-03-10 00:00:00
abstract:BACKGROUND:Tick-borne relapsing fevers of humans are caused by spirochetes that must adapt to both warm-blooded vertebrates and cold-blooded ticks. In western North America, most human cases of relapsing fever are caused by Borrelia hermsii, which cycles in nature between its tick vector Ornithodoros hermsi and small m...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-015-1170-1
更新日期:2015-10-21 00:00:00
abstract::Since 2004 there has been an increased recognition of the importance of Neglected Tropical Diseases (NTDs) as impediments to development. These diseases are caused by a variety of infectious agents - viruses, bacteria and parasites - which cause a diversity of clinical conditions throughout the tropics. The World Heal...
journal_title:Parasites & vectors
pub_type: 杂志文章,评审
doi:10.1186/1756-3305-4-234
更新日期:2011-12-13 00:00:00
abstract:BACKGROUND:Despite intensive control measures including governmental campaigns using highly-efficacious systemic insecticides, there is evidence for persisting or recurring bovine Hypoderma species populations in parts of Europe, the USA and Canada. The present study evaluated the efficacy of LONGRANGE® (eprinomectin 5...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-019-3475-y
更新日期:2019-05-14 00:00:00
abstract:BACKGROUND:Schistosomiasis japonica remains a major public health concern in China. There are many interventions implemented to control the transmission of the disease. The purpose of the present study was to investigate the effects of an integrated control strategy for schistosomiasis control. METHODS:An integrated c...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/1756-3305-4-243
更新日期:2011-12-30 00:00:00
abstract:BACKGROUND:Insect-specific viruses do not replicate in vertebrate cells, but persist in mosquito populations and are highly prevalent in nature. These viruses may naturally regulate the transmission of pathogenic vertebrate-infecting arboviruses in co-infected mosquitoes. Following the isolation of the first Australian...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-016-1683-2
更新日期:2016-07-25 00:00:00