Elevated Inflammatory Plasma Biomarkers in Patients With Fabry Disease: A Critical Link to Heart Failure With Preserved Ejection Fraction.

abstract：BACKGROUND:Cardiac magnetic resonance (CMR) can quantify myocardial infarct (MI) size and myocardium at risk (MaR), enabling assessment of myocardial salvage index (MSI). We assessed how MSI impacts the number of patients needed to reach statistical power in relation to MI size alone and levels of biochemical markers i...

journal_title：Journal of the American Heart Association

authors： Engblom H,Heiberg E,Erlinge D,Jensen SE,Nordrehaug JE,Dubois-Randé JL,Halvorsen S,Hoffmann P,Koul S,Carlsson M,Atar D,Arheden H

更新日期：2016-03-09 00:00:00

abstract：BACKGROUND:Transseptal puncture is a critical step in achieving left atrial (LA) access for a variety of cardiac procedures. Although the mechanical Brockenbrough needle has historically been used for this procedure, a needle employing radiofrequency (RF) energy has more recently been approved for clinical use. We soug...

journal_title：Journal of the American Heart Association

authors： Hsu JC,Badhwar N,Gerstenfeld EP,Lee RJ,Mandyam MC,Dewland TA,Imburgia KE,Hoffmayer KS,Vedantham V,Lee BK,Tseng ZH,Scheinman MM,Olgin JE,Marcus GM

更新日期：2013-09-17 00:00:00

abstract：BACKGROUND:Few studies have examined the impact of lifecourse socioeconomic position (SEP) on cardiovascular disease (CVD) risk among African Americans. METHODS AND RESULTS:We used data from the Jackson Heart Study (JHS) to examine the associations of multiple measures of lifecourse SEP with CVD events in a large coho...

journal_title：Journal of the American Heart Association

authors： Gebreab SY,Diez Roux AV,Brenner AB,Hickson DA,Sims M,Subramanyam M,Griswold ME,Wyatt SB,James SA

更新日期：2015-05-27 00:00:00

abstract：BACKGROUND:People with end-stage renal disease (ESRD) are at risk for advanced heart failure, but little is known about use and outcomes of durable mechanical circulatory support in this setting. We examined use and outcomes of implantable ventricular assist devices (VADs) in a national ESRD cohort. METHODS AND RESULT...

journal_title：Journal of the American Heart Association

authors： Walther CP,Niu J,Winkelmayer WC,Cheema FH,Nair AP,Morgan JA,Fedson SE,Deswal A,Navaneethan SD

更新日期：2018-07-06 00:00:00

abstract：:Background We aimed to determine if there is an association between hospital quality and the likelihood of a given hospital being a preferred transfer destination for stroke patients. Methods and Results Data from Medicare claims identified acute ischemic stroke transferred between 394 northeast US hospitals from 2007...

journal_title：Journal of the American Heart Association

authors： Zachrison KS,Onnela JP,Reeves MJ,Hernandez A,Camargo CA Jr,Zhao X,Matsouaka RA,Goldstein JN,Metlay JP,Schwamm LH

更新日期：2020-01-07 00:00:00

abstract：:Background Many patients use opioids for nonmalignant pain, and opioid use in the general population has been associated with poor long-term outcomes. The use of high-risk medications, including opioid analgesics, may increase the risk of unplanned healthcare utilization. Methods and Results We performed a nested eval...

journal_title：Journal of the American Heart Association

authors： Liberman JS,Samuels LR,Goggins K,Kripalani S,Roumie CL,VICS (Vanderbilt Inpatient Cohort Study).

更新日期：2019-02-05 00:00:00

abstract：BACKGROUND:We examined the role of menopause on cardiac dimensions and function and assessed the efficacy of exercise training before and after menopause. METHODS AND RESULTS:Two groups of healthy premenopausal (n=36, 49.4±0.3 years) and postmenopausal (n=37, 53.5±0.5 years) women with no history of cardiovascular dis...

journal_title：Journal of the American Heart Association

authors： Egelund J,Jørgensen PG,Mandrup CM,Fritz-Hansen T,Stallknecht B,Bangsbo J,Nyberg M,Hellsten Y

更新日期：2017-08-18 00:00:00

abstract：:Background Muscular dystrophy (MD) causes a progressive cardiomyopathy characterized by diffuse fibrosis, arrhythmia, heart failure, and early death. Activation of the thromboxane-prostanoid receptor (TPr) increases calcium transients in cardiomyocytes and is proarrhythmic and profibrotic. We hypothesized that TPr act...

journal_title：Journal of the American Heart Association

authors： West JD,Galindo CL,Kim K,Shin JJ,Atkinson JB,Macias-Perez I,Pavliv L,Knollmann BC,Soslow JH,Markham LW,Carrier EJ

更新日期：2019-11-05 00:00:00

abstract：:Background The ODYSSEY OUTCOMES (Alirocumab and Cardiovascular Outcomes after Acute Coronary Syndrome) trial demonstrated that alirocumab reduced major cardiovascular events. However, because of the hierarchical testing strategy used for the multiple outcomes examined, the observed reduction in all-cause mortality was...

journal_title：Journal of the American Heart Association

authors： Labos C,Brophy JM,Sniderman A,Thanassoulis G

更新日期：2019-10-15 00:00:00

abstract：BACKGROUND:NO bioavailability has not been systematically examined in congenital heart disease (CHD). To assess NO in patients with CHD, we measured nasal NO (nNO) generated by the nasal epithelia, given blood NO is difficult to measure (half-life, <2 ms). Given NO's role in hemodynamic regulation and the association o...

journal_title：Journal of the American Heart Association

authors： Adams PS,Zahid M,Khalifa O,Feingold B,Lo CW

更新日期：2017-12-06 00:00:00

abstract：:Background We aimed to determine the change in treatment strategies and times to treatment over the first 5 years of the Mission: Lifeline program. Methods and Results We assessed pre- and in-hospital care and outcomes from 2008 to 2012 for patients with ST -segment-elevation myocardial infarction at US hospitals, usi...

journal_title：Journal of the American Heart Association

authors： Granger CB,Bates ER,Jollis JG,Antman EM,Nichol G,O'Connor RE,Gregory T,Roettig ML,Peng SA,Ellrodt G,Henry TD,French WJ,Jacobs AK

更新日期：2019-01-08 00:00:00

abstract：:Background Although PAR-1 (protease-activated receptor-1) exerts important functions in the pathophysiology of the cardiovascular system, the role of PAR-1 signaling in heart failure development remains largely unknown. We tested the hypothesis that PAR-1 signaling inhibition has protective effects on the progression ...

journal_title：Journal of the American Heart Association

authors： Yokono Y,Hanada K,Narita M,Tatara Y,Kawamura Y,Miura N,Kitayama K,Nakata M,Nozaka M,Kato T,Kudo N,Tsushima M,Toyama Y,Itoh K,Tomita H

更新日期：2020-06-16 00:00:00

abstract：BACKGROUND:The structure of the aorta is considered to influence exercise systolic blood pressure (SBP) response, which, in turn, might impact upon adverse outcomes. The current study sought to investigate the relationship of aortic calcification and exercise SBP with adverse outcomes among elderly individuals. METHOD...

journal_title：Journal of the American Heart Association

authors： Cho IJ,Chang HJ,Cho I,Heo R,Lee SE,Shim CY,Hong GR,Chung N

更新日期：2016-04-22 00:00:00

abstract：:Background Hypertrophic cardiomyopathy (HCM) is the most common inherited cardiomyopathy. Current guidelines endorse management in expert centers, but patient socioeconomic status can affect access to specialty care. The effect of socioeconomic status and specialty care access on HCM outcomes has not been examined. Me...

journal_title：Journal of the American Heart Association

authors： Thomas A,Papoutsidakis N,Spatz E,Testani J,Soucier R,Chou J,Ahmad T,Darr U,Hu X,Li F,Chen ME,Bellumkonda L,Sumathipala A,Jacoby D

更新日期：2020-02-04 00:00:00

abstract：:Background Recent publications reached conflicting conclusions about the cost-effectiveness of left atrial appendage closure (LAAC) with the Watchman device (Boston Scientific, Marlborough, MA) for stroke risk reduction in nonvalvular atrial fibrillation (AF). This analysis sought to assess the cost-effectiveness of L...

journal_title：Journal of the American Heart Association

authors： Reddy VY,Akehurst RL,Gavaghan MB,Amorosi SL,Holmes DR Jr

更新日期：2019-07-02 00:00:00

abstract：BACKGROUND:Platelet activation can lead to enhanced oxidative stress, inflammatory response, and endothelial dysfunction. To quantify the effects of platelet inhibition on endothelial function, we assessed platelet activity of healthy persons before and after clopidogrel administration and evaluated its effects on endo...

journal_title：Journal of the American Heart Association

authors： Salimi S,Lewis JP,Yerges-Armstrong LM,Mitchell BD,Saeed F,O'Connell JR,Perry JA,Ryan KA,Shuldiner AR,Parsa A

更新日期：2016-10-31 00:00:00

abstract：BACKGROUND:There are several mechanisms, including inflammation, oxidative stress and abnormal calcium homeostasis, involved in the pathogenesis of atrial fibrillation. In diabetes mellitus (DM), increased oxidative stress may be attributable to higher xanthine oxidase activity. In this study, we examined the relations...

journal_title：Journal of the American Heart Association

authors： Yang Y,Zhao J,Qiu J,Li J,Liang X,Zhang Z,Zhang X,Fu H,Korantzopoulos P,Letsas KP,Tse G,Li G,Liu T

更新日期：2018-05-02 00:00:00

abstract：BACKGROUND:Higher heart rate has been associated with an adverse prognosis, but most prior studies focused on individuals with known cardiovascular disease or examined a limited number of outcomes. We sought to examine the association of baseline heart rate with both fatal and nonfatal outcomes during 2 decades of foll...

journal_title：Journal of the American Heart Association

authors： Ho JE,Larson MG,Ghorbani A,Cheng S,Coglianese EE,Vasan RS,Wang TJ

更新日期：2014-05-08 00:00:00

abstract：:Background The regulation of sodium excretion is important in the pathogenesis of hypertension and salt sensitivity is predictive of cardiovascular events and mortality. C57Bl/6 and BALB/c mice have different blood pressure sensitivities to salt intake. High salt intake increases blood pressure in some C57Bl/6J mouse ...

journal_title：Journal of the American Heart Association

authors： Cuevas S,Asico LD,Jose PA,Konkalmatt P

更新日期：2020-01-07 00:00:00

abstract：BACKGROUND:The amino acid response (AAR) is an evolutionarily conserved protective mechanism activated by amino acid deficiency through a key kinase, general control nonderepressible 2. In addition to mobilizing amino acids, the AAR broadly affects gene and protein expression in a variety of pathways and elicits antifi...

journal_title：Journal of the American Heart Association

authors： Qin P,Arabacilar P,Bernard RE,Bao W,Olzinski AR,Guo Y,Lal H,Eisennagel SH,Platchek MC,Xie W,Del Rosario J,Nayal M,Lu Q,Roethke T,Schnackenberg CG,Wright F,Quaile MP,Halsey WS,Hughes AM,Sathe GM,Livi GP,Kirkpatri

更新日期：2017-05-09 00:00:00

abstract：BACKGROUND:The liver X receptors (LXRs; α/β) are nuclear receptors known to regulate cholesterol homeostasis and the production of select hematopoietic populations. The objective of this study was to determine the importance of LXRs and a high-fat high-cholesterol diet on global hematopoiesis, with special emphasis on ...

journal_title：Journal of the American Heart Association

authors： Rasheed A,Tsai R,Cummins CL

更新日期：2018-05-08 00:00:00

abstract：BACKGROUND:Left ventricular noncompaction (LVNC) has since been classified as a primary genetic cardiomyopathy, but the genetic basis is not fully evaluated. The aim of the present study was to identify the genetic spectrum using next-generation sequencing and to evaluate genotype-phenotype correlations in LVNC patient...

journal_title：Journal of the American Heart Association

authors： Wang C,Hata Y,Hirono K,Takasaki A,Ozawa SW,Nakaoka H,Saito K,Miyao N,Okabe M,Ibuki K,Nishida N,Origasa H,Yu X,Bowles NE,Ichida F,for LVNC Study Collaborators.

更新日期：2017-08-30 00:00:00

abstract：BACKGROUND:Currently, acute ischemic stroke is still a leading cause of mortality and morbidity. Approximately 2 years ago, mechanical thrombectomy was proven beneficial as a revolutionary new therapy for stroke in the MR-CLEAN trial (A Multicenter Randomized Clinical Trial of Endovascular Treatment for Acute Ischemic ...

journal_title：Journal of the American Heart Association

authors： Autar ASA,Hund HM,Ramlal SA,Hansen D,Lycklama À Nijeholt GJ,Emmer BJ,de Maat MPM,Dippel DWJ,van der Lugt A,van Es ACGM,van Beusekom HMM,MR CLEAN Registry Investigators.

更新日期：2018-06-22 00:00:00

abstract：BACKGROUND:The postnatal development of myofibrillar mechanics, a major determinant of heart function, is unknown in pediatric patients with tetralogy of Fallot and related structural heart defects. We therefore determined the mechanical properties of myofibrils isolated from right ventricular tissue samples from such ...

journal_title：Journal of the American Heart Association

authors： Elhamine F,Iorga B,Krüger M,Hunger M,Eckhardt J,Sreeram N,Bennink G,Brockmeier K,Pfitzer G,Stehle R

更新日期：2016-06-27 00:00:00

abstract：BACKGROUND:The atherosclerosis cardiovascular disease (ASCVD) Pooled Cohort risk equations have shown different calibration across US populations with varied levels of social deprivation. METHODS AND RESULTS:We analyzed the calibration and discrimination of the Pooled Cohort risk equations by social deprivation status...

journal_title：Journal of the American Heart Association

authors： Colantonio LD,Richman JS,Carson AP,Lloyd-Jones DM,Howard G,Deng L,Howard VJ,Safford MM,Muntner P,Goff DC Jr

更新日期：2017-03-17 00:00:00

abstract：BACKGROUND:Previous studies have documented a high prevalence of atrial fibrillation (AF) in individuals with obstructive sleep apnea (OSA). Central sleep apnea (CSA) has been associated with AF in patients with heart failure. However, data from prospective cohorts are sparse and few studies have distinguished the asso...

journal_title：Journal of the American Heart Association

authors： Tung P,Levitzky YS,Wang R,Weng J,Quan SF,Gottlieb DJ,Rueschman M,Punjabi NM,Mehra R,Bertisch S,Benjamin EJ,Redline S

更新日期：2017-07-01 00:00:00

abstract：BACKGROUND:Many patients requiring a pacemaker have persistent hypertension with systolic blood pressures above recommended levels. We evaluated a pacemaker-based Programmable Hypertension Control (PHC) therapy that uses a sequence of variably timed shorter and longer atrioventricular intervals. METHODS AND RESULTS:Pa...

journal_title：Journal of the American Heart Association

authors： Neuzil P,Merkely B,Erglis A,Marinskis G,de Groot JR,Schmidinger H,Rodriguez Venegas M,Voskuil M,Sturmberger T,Petru J,Jongejan N,Aichinger J,Kamzola G,Aidietis A,Gellér L,Mraz T,Osztheimer I,Mika Y,Evans S,Burkhoff

更新日期：2017-12-23 00:00:00

abstract：BACKGROUND:Whether heart rate upon discharge following hospitalization for heart failure is associated with long-term adverse outcomes and whether this association differs between patients with sinus rhythm (SR) and atrial fibrillation (AF) have not been well studied. METHODS AND RESULTS:We conducted a retrospective c...

journal_title：Journal of the American Heart Association

authors： Laskey WK,Alomari I,Cox M,Schulte PJ,Zhao X,Hernandez AF,Heidenreich PA,Eapen ZJ,Yancy C,Bhatt DL,Fonarow GC,AHA Get With The Guidelines®‐Heart Failure Program.

更新日期：2015-04-22 00:00:00

abstract：BACKGROUND:Fatty infiltration of the pancreas is an enigmatic manifestation of ectopic fat deposition in obesity. Studies have shown that pancreatic lipid accumulation interferes with insulin secretion in humans. However, the prevalence of fatty pancreas and its associated factors in the general population remain uncle...

journal_title：Journal of the American Heart Association

authors： Wang CY,Ou HY,Chen MF,Chang TC,Chang CJ

更新日期：2014-02-26 00:00:00

abstract：BACKGROUND:Physical activity is of benefit for primary prevention of cardiovascular diseases, but it appears to increase the risk for atrial fibrillation. We aimed to study a cohort of patients following a first stroke in individuals with previous high physical activity, compare them to the general population with resp...

journal_title：Journal of the American Heart Association

authors： Hållmarker U,Åsberg S,Michaëlsson K,Ärnlöv J,Hellberg D,Lindbäck J,Wester P,James S

更新日期：2015-09-24 00:00:00