Abstract:
INTRODUCTION:Drug-resistant tuberculosis (TB) is a global concern. The proper diagnosis and management of drug-resistant TB are critical for improving treatment outcome. Molecular-based genotypic drug-susceptibility testing (DST) was developed to identify drug-resistant TB; however, discordant results from phenotypic and genotypic DST analyses have alarmed clinicians and raised concerns about the test's utility. Moreover, the characteristics of disputed mutations are not well studied and only based on retrospective study findings. METHODS AND ANALYSIS:We describe a 28-month prospective observational cohort study ongoing at two university-affiliated hospitals in South Korea. The cohort study will enrol and evaluate 600 adults with pulmonary TB. Relevant clinical and epidemiological data will be collected prospectively and participants will be evaluated at each hospital during anti-TB treatment to identify factors associated with TB treatment outcomes. Respiratory specimens will be collected at select visits. After generating a well-characterised cohort, patterns of drug resistance on both phenotypic and genotypic DSTs and associated mutations including the disputed mutation will be evaluated. We will also identify various clinical and socioeconomic factors that affect the causes of drug resistance and their clinical outcomes. ETHICS AND DISSEMINATION:The study protocol is approved by the Institutional Review Boards of Chungbuk National University Hospital and Chungnam National University Hospital. Study results will be disseminated through peer-reviewed journals and conference presentations. TRIAL REGISTRATION NUMBER:KCT0002594.
journal_name
BMJ Openjournal_title
BMJ openauthors
Min J,Chung C,Lim J,Park JH,Shin KS,Jung SS,Lee KMdoi
10.1136/bmjopen-2017-021235subject
Has Abstractpub_date
2018-10-10 00:00:00pages
e021235issue
10issn
2044-6055pii
bmjopen-2017-021235journal_volume
8pub_type
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