Abstract:
INTRODUCTION:Thrombocytopaenia is one of the most common haemostatic abnormalities among neonates. It affects approximately one-quarter of neonates admitted into neonatal intensive care units and may lead to a high risk of bleeding and mortality, which are substantial causes for concern by neonatologists. Platelet transfusion (PT) is a specific treatment for thrombocytopaenia. To date, PT thresholds are diverse since the associations between low platelet count and negative outcomes are not clear. We propose this protocol for a systematic review to collect and assess evidence concerning the best PT threshold to reduce mortality, bleeding and major morbidity among neonates with thrombocytopaenia. METHODS AND ANALYSIS:The systematic review will be performed according to the Cochrane Handbook for Systematic Review of Interventions, the Preferred Reporting Items for Systematic Reviews and Meta-Analyses statement, and the Grading of Recommendations Assessment, Development and Evaluation system. Two independent researchers will perform the study selection, data extraction/coding, quality assessment and further analyses of the included studies, with disagreements being resolved by a third researcher. A systematic search of the literature will be conducted in the PubMed, Cochrane Library and Embase databases from database inception through 13 October 2020. All randomised controlled trials, cohort studies and case-control studies will be included without any restrictions regarding publication date or language. The primary outcomes will comprise in-hospital mortality and bleeding episodes. Endnote X9 and Review Manager V.5.3 software will be used to manage the selection process and statistical analysis, respectively. If the included studies are sufficient and homogeneous for any of the outcomes, a quantitative synthesis (meta-analysis) may be performed. Otherwise, we will conduct a narrative systematic review of the results. ETHICS AND DISSEMINATION:Ethical approval is not required for this study because the data will be obtained from published studies and will not include individual patient data. The results of this study are anticipated to be published in a peer-reviewed journal. PROSPERO REGISTRATION NUMBER:CRD42020169262.
journal_name
BMJ Openjournal_title
BMJ openauthors
Liu D,Wu J,Xiong T,Yue Y,Tang Jdoi
10.1136/bmjopen-2020-039132subject
Has Abstractpub_date
2020-10-16 00:00:00pages
e039132issue
10issn
2044-6055pii
bmjopen-2020-039132journal_volume
10pub_type
杂志文章相关文献
BMJ Open文献大全abstract:OBJECTIVE:To summarise the findings of an updated Cochrane review of interventions aimed at improving the appropriate use of polypharmacy in older people. DESIGN:Cochrane systematic review. Multiple electronic databases were searched including MEDLINE, EMBASE and the Cochrane Central Register of Controlled Trials (fro...
journal_title:BMJ open
pub_type: 杂志文章,评审
doi:10.1136/bmjopen-2015-009235
更新日期:2015-12-09 00:00:00
abstract:OBJECTIVE:Our cross-sectional study aimed at evaluating the diagnostic performance of Focused Assessment with Sonography for HIV-associated tuberculosis (FASH) to detect extrapulmonary tuberculosis in extremely resource-limited settings, with visceral leishmaniasis as a differential diagnosis with overlapping sonograph...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2018-027179
更新日期:2019-04-02 00:00:00
abstract:OBJECTIVES:To determine the validity and reliability of the Spiritual Care Competency Scale (SCCS) among nurses in China. DESIGN:Methodological research. METHODS:After the SCCS was translated into Chinese, the validity and reliability of the Chinese version of the SCCS (C-SCCS) were evaluated using a convenience samp...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2019-030497
更新日期:2019-10-10 00:00:00
abstract::Objectives Diagnoses-specific sickness certification guidelines were recently introduced in Sweden. The aim of this study was to investigate to which extent general practitioners (GPs) used these guidelines and how useful they found them, 1 year after introduction. Design A cross-sectional questionnaire study. A comp...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2011-000303
更新日期:2011-12-20 00:00:00
abstract:OBJECTIVE:The aim of this study was to assess the knowledge and practice of health workers about multidrug-resistant tuberculosis (MDR-TB) prevention and control. STUDY DESIGN AND SETTINGS:A cross-sectional study was conducted at Gondar University Referral Hospital and Felege Hiwot Referral Hospital. PARTICIPANTS:Ran...
journal_title:BMJ open
pub_type: 杂志文章,多中心研究
doi:10.1136/bmjopen-2018-022948
更新日期:2019-02-19 00:00:00
abstract:OBJECTIVE:Primarily to develop a multimarker score for prediction of 3-year mortality in older patients with decompensated heart failure (HF). DESIGN:Prospective cohort study. SETTING:Secondary care. Single centre. PATIENTS AND BIOMARKERS: 131 patients, aged ≥65 years, with decompensated HF were included. Assessment ...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2012-002254
更新日期:2013-03-09 00:00:00
abstract:OBJECTIVE:To describe the range and nature of available research regarding sources of information that patients access to inform their decisions about elective surgery. DESIGN:Scoping review. DATA SOURCES:Peer-reviewed studies published until February 2019 from the six scientific literature databases were searched an...
journal_title:BMJ open
pub_type: 杂志文章,评审
doi:10.1136/bmjopen-2018-023080
更新日期:2019-08-05 00:00:00
abstract:INTRODUCTION:Exercise and physical activity (PA) are established and effective treatment options for various side effects of cancer treatments such as surgery, chemotherapy and radiotherapy. The advent of eHealth brings new opportunities to influence healthy behaviours, using interactive and novel approaches. Influenci...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2018-024999
更新日期:2019-03-08 00:00:00
abstract:OBJECTIVES:Overweight and obesity remain at historically high levels, cluster within families and are established risk factors for multiple diseases. We describe the epidemiology and cross-generational concordance of body composition among Australian children aged 11-12 years and their parents. DESIGN:The population-b...
journal_title:BMJ open
pub_type: 杂志文章,多中心研究
doi:10.1136/bmjopen-2018-023698
更新日期:2019-07-04 00:00:00
abstract:OBJECTIVES:To investigate known and suggested risk factors associated with cerebral palsy in a Swedish birth cohort, stratified by gestational age. SETTING:Information on all births between 1995 and 2014 in Skåne, the southernmost region in Sweden, was extracted from the national birth register. PARTICIPANTS:The coho...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2020-038453
更新日期:2020-08-07 00:00:00
abstract:OBJECTIVE:We report on: (1) the proportion of patients with known atrial fibrillation (AF); and (2) demographic, clinical or radiological differences between patients with known AF (and not treated) and patients with newly diagnosed AF, in a cohort of patients who presented with ischaemic stroke or transient ischaemic ...
journal_title:BMJ open
pub_type: 杂志文章,多中心研究
doi:10.1136/bmjopen-2018-028387
更新日期:2019-07-24 00:00:00
abstract:OBJECTIVES:Develop predictive models for a paediatric population that provide information for paediatricians and health authorities to identify children at risk of hospitalisation for conditions that may be impacted through improved patient care. DESIGN:Retrospective healthcare utilisation analysis with multivariable ...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2017-019454
更新日期:2018-05-05 00:00:00
abstract:BACKGROUND:First responders (police, fire and ambulance officers) are at a significantly increased risk of experiencing poor mental health, including depression and post-traumatic stress disorder. These conditions are associated with high rates of cardiovascular disease, in part due to low levels of physical activity (...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2019-030668
更新日期:2019-09-11 00:00:00
abstract:OBJECTIVES:To estimate the prevalence of poor vision in children aged 4-5 years and determine the impact of visual acuity on literacy. DESIGN:Cross-sectional study linking clinical, epidemiological and education data. SETTING:Schools located in the city of Bradford, UK. PARTICIPANTS:Prevalence was determined for 11,...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2015-010434
更新日期:2016-02-16 00:00:00
abstract:OBJECTIVES:(1) Investigate and explore whether different classes of associative stigma (the process by which a person experiences stigmatisation as a result of an association with another stigmatised person) could be identified using latent class analysis; (2) determine the sociodemographic and employment-related corre...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2018-028179
更新日期:2019-07-11 00:00:00
abstract:INTRODUCTION:Major depression is a highly prevalent pathology that is currently the second most common cause of disease-induced disability in our society. The onset and continuation of depression may be related to a wide variety of biological and psychosocial factors, many of which are linked to different lifestyle asp...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2020-038457
更新日期:2020-12-28 00:00:00
abstract:INTRODUCTION:The ongoing opioid epidemic has necessitated increasing prescriptions of buprenorphine, which is an evidence-based treatment for opioid use disorder, and also shown to reduce harms associated with unsafe opioid administration. A systematic review of perioperative management strategies for patients taking b...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2018-027374
更新日期:2019-05-22 00:00:00
abstract:OBJECTIVES:According to a large-scale international survey, Peru has one of the highest prevalences of asthma worldwide; however, data from this survey were limited to participants from urban Lima. The authors sought to characterise the epidemiology of asthma in Peru in two regions with disparate degrees of urbanisatio...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2011-000421
更新日期:2012-02-22 00:00:00
abstract:OBJECTIVE:The objective is to evaluate efficiency based on data on morbidity and mortality, health-related quality of life and healthcare-related costs after early reversal of temporary ileostomy after rectal resection for cancer compared with the standard procedure (late reversal). BACKGROUND:Reversal of a temporary ...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2011-000162
更新日期:2011-07-29 00:00:00
abstract:INTRODUCTION:Catatonia arises from serious mental, medical, neurological or toxic conditions. The prevalence range depends on the setting and the range is anything from 7% to 63% in other countries. South African prevalence rates are currently unknown. The proposed study is a quantitative descriptive study using the Bu...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2020-040176
更新日期:2020-11-06 00:00:00
abstract:OBJECTIVE:To measure the experience and perpetration of negative behaviour, including domestic violence and abuse (DVA), and investigate its associations with health conditions and behaviours in men attending general practice. DESIGN:Cross-sectional questionnaire-based study conducted between September 2010 and June 2...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2014-007141
更新日期:2015-05-19 00:00:00
abstract:OBJECTIVES:To investigate the prevalence of mild cognitive impairment and the relationship with plasma aluminium among aluminium workers. DESIGN:This was a cross-sectional case-control study in the SH Aluminium Factory, China. SETTING:The university and affiliated hospital cooperated in the study. PARTICIPANTS:There...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2018-027154
更新日期:2019-06-16 00:00:00
abstract:OBJECTIVES:To explore the experiences of caregivers living with relatives affected by Crohn's disease (CD) in a context in which the family provides social support. DESIGN:A qualitative study based on a phenomenological approach was conducted through in-depth interviews. SETTING:Participants living in Alicante (Spain...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2019-030625
更新日期:2019-10-22 00:00:00
abstract:OBJECTIVE:To test agreement of two methods to measure intraocular pressure (IOP): rebound tonometry (RBT) and gold standard Goldmann applanation tonometry (GAT) in children with glaucoma. DESIGN:Observational prospective cohort study. SETTING:Tertiary paediatric glaucoma clinic at a single centre. PARTICIPANTS:102 i...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2012-001788
更新日期:2013-04-02 00:00:00
abstract:OBJECTIVES:To analyse free-text responses from the first Scottish Cancer Patient Experience Survey (SCPES) to understand patients' experiences of care, identify valued aspects and areas for improvement. DESIGN:Inductive thematic analysis of seven free-text comment boxes covering all stages of the cancer experience, fr...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2016-015726
更新日期:2017-06-15 00:00:00
abstract:OBJECTIVE:To systematically search for research about the effectiveness of mandatory reporting of child maltreatment and to synthesise qualitative research that explores mandated reporters' (MRs) experiences with reporting. DESIGN:As no studies assessing the effectiveness of mandatory reporting were retrieved from our...
journal_title:BMJ open
pub_type: 杂志文章,meta分析,评审
doi:10.1136/bmjopen-2016-013942
更新日期:2017-10-16 00:00:00
abstract:OBJECTIVES:Two oral targeted therapies, gefitinib and erlotinib, were first approved and then launched into the market for treatment of late-stage non-small cell lung cancer (NSCLC) in Taiwan in 2003 and 2006, respectively. The aim of this study were to determine the trends in lung cancer burden and examine changes in ...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2019-033427
更新日期:2020-05-10 00:00:00
abstract:OBJECTIVE:The aims of this study were to describe the experiences of senior students using mobile devices in a clinical setting while learning and interacting with clinical teachers, patients and each other, and to identify challenges that facilitated or impeded the use of such devices in the hospital. DESIGN:Interpre...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2016-011896
更新日期:2016-05-03 00:00:00
abstract:INTRODUCTION:Policing practices are key drivers of HIV among people who inject drugs (PWID). This paper describes the protocol for the first study to prospectively examine the impact of a police education programme (PEP) to align law enforcement and HIV prevention. PEPs incorporating HIV prevention (including harm redu...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2015-008958
更新日期:2015-08-10 00:00:00
abstract:OBJECTIVE:The International Agency for Research on Cancer classifies hexavalent chromium (Cr(VI)) as a human carcinogen. As reported, cancer mortality was higher in Cr(VI)-contaminated areas. Scientists have recommended studying its health impact on people living in contaminated areas. This study aims to evaluate the h...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2017-021470
更新日期:2018-06-27 00:00:00