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New Molecular Technologies for Minimal Residual Disease Evaluation in B-Cell Lymphoid Malignancies.

Abstract：

:The clearance of malignant clonal cells significantly correlates with clinical outcomes in many hematologic malignancies. Accurate and high throughput tools for minimal residual disease (MRD) detection are needed to overcome some drawbacks of standard molecular techniques; such novel tools have allowed for higher sensitivity analyses and more precise stratification of patients, based on molecular response to therapy. In this review, we depict the recently introduced digital PCR and next-generation sequencing technologies, describing their current application for MRD monitoring in lymphoproliferative disorders. Moreover, we illustrate the feasibility of these new technologies to test less invasive and more patient-friendly tissues sources, such as "liquid biopsy".

journal_name

J Clin Med

journal_title

Journal of clinical medicine

authors

Dogliotti I,Drandi D,Genuardi E,Ferrero S

doi

10.3390/jcm7090288

subject

Has Abstract

pub_date

2018-09-18 00:00:00

issue

9

issn

2077-0383

pii

jcm7090288

journal_volume

7

pub_type

杂志文章,评审

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