Abstract:
Background:Bushen Huoxue decoction (BHD) has a significant effect on fracture rehabilitation, yet its underlying mechanism is still unknown. The purpose of this study was to explore whether BHD promotes bone marrow mesenchymal stem cell (BMSC) migration through the Wnt5a signalling pathway. Methods:BHD was extracted by petroleum, and its composition was analysed. Cell viability in the presence of various concentrations of BHD for 24, 48 and 72 h was measured using a Cell Counting Kit-8 assay. Transwell assays and wound healing assays were used to observe the migration ability of BMSCs. Lentiviral vectors were used to knock down Wnt5a. Polymerase chain reaction and Western blot analyses were used to further compare Wnt5a signalling components at the mRNA and protein levels between groups. Results:BHD treatment groups showed increased migration ability and Wnt5a expression. Knocking down Wnt5a using a lentivirus significantly inhibited the effects of BHD, which implies that BHD promotes BMSC migration ability through activation of Wnt5a. Conclusions:BHD can enhance BMSC migration, possibly by activating Wnt5a signalling.
journal_name
Chin Medjournal_title
Chinese medicineauthors
Shen W,Luo H,Xu L,Wu Z,Chen H,Liu Y,Yu L,Hu L,Wang B,Luo Ydoi
10.1186/s13020-018-0200-2subject
Has Abstractpub_date
2018-08-29 00:00:00pages
45issn
1749-8546pii
200journal_volume
13pub_type
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