Abstract：
BACKGROUND:Angiostrongylus cantonensis is an important causative agent of eosinophilic meningitis and eosinophilic meningoencephalitis in humans. Previous studies have shown that the Sonic hedgehog (Shh) signaling pathway may reduce cell apoptosis by inhibiting oxidative stress in A. cantonensis infection. In this study, we investigated the relationship between cytokine secretion and Shh pathway activation after treatment with excretory/secretory products (ESP) of fifth-stage larval A. cantonensis (L5). RESULTS:The results showed that IL-1β and IL-6 levels in mouse astrocytes were increased. Moreover, ESP stimulated the protein expression of Shh pathway molecules, including Shh, Ptch, Smo and Gli-1, and induced IL-1β and IL-6 secretion. The transcription factor nuclear factor-κB (NF-κB) plays an important role in inflammation, and it regulates the expression of proinflammatory genes, including cytokines and chemokines, such as IL-1β and TNF-α. After ESP treatment, NF-κB induced IL-1β and IL-6 secretion in astrocytes by activating the Shh signaling pathway. CONCLUSIONS:Overall, the data presented in this study showed that ESP of fifth-stage larval A. cantonensis stimulates astrocyte activation and cytokine generation through NF-κB and the Shh signaling pathway.
journal_name
Parasit Vectorsjournal_title
Parasites & vectorsauthors
Chen KY,Wang LCdoi
10.1186/s13071-017-2385-0subject
Has Abstractpub_date
2017-09-26 00:00:00pages
445issue
1issn
1756-3305pii
10.1186/s13071-017-2385-0journal_volume
10pub_type
杂志文章abstract：BACKGROUND:Aedes albopictus (Skuse) is an invasive mosquito that has become an important vector of chikungunya, dengue and Zika viruses. In the absence of specific antiviral therapy or a vaccine, vector management is the sole method available for reducing Aedes-induced disease morbidity. Determining the resistance stat...
journal_title：Parasites & vectors
pub_type： 杂志文章
doi：10.1186/s13071-017-2581-y
更新日期：2018-01-03 00:00:00
abstract：BACKGROUND:Cyathostomins infect virtually all horses, and concomitant infections with 10 or more species per horse is standard. Species-specific knowledge is limited, despite potential species bias in development of disease and anthelmintic resistance. This is the first meta-analysis to examine effects of geographical ...
journal_title：Parasites & vectors
pub_type： 杂志文章
doi：10.1186/s13071-020-04396-5
更新日期：2020-10-12 00:00:00
abstract：:Schistosomiasis is a major disease of public health importance in humans occurring in 76 countries of the tropics and sub-tropics. In China, schistosomiasis japonica is one of the highest priorities in communicable disease control defined by the central government. Since 1970s, the habitats of Biomphalaria straminea, ...
journal_title：Parasites & vectors
pub_type： 杂志文章,评审
doi：10.1186/1756-3305-6-249
更新日期：2013-08-28 00:00:00
abstract：BACKGROUND:Anopheles culicifacies s.l. is one of the primary vectors of malaria in India responsible for the highest number of malaria cases. This vector is resistant to DDT in most parts of the country with indication of emerging resistance to pyrethroids. Since knockdown resistance (kdr) is known to confer cross-resi...
journal_title：Parasites & vectors
pub_type： 杂志文章
doi：10.1186/s13071-015-0946-7
更新日期：2015-06-18 00:00:00
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journal_title：Parasites & vectors
pub_type： 杂志文章
doi：10.1186/1756-3305-5-7
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journal_title：Parasites & vectors
pub_type： 杂志文章
doi：10.1186/1756-3305-7-224
更新日期：2014-05-14 00:00:00
abstract：BACKGROUND:Liver fluke (Fasciola hepatica) is a widespread parasite of ruminants which can have significant economic impact on cattle production. Fluke infection status at the animal-level is captured during meat inspection of all animals processed for human consumption within Northern Ireland. These national datasets ...
journal_title：Parasites & vectors
pub_type： 杂志文章
doi：10.1186/s13071-016-1489-2
更新日期：2016-04-14 00:00:00
abstract：BACKGROUND:Thelazia callipaeda is transmitted by Phortica variegata, a drosophilid that feeds on lachrymal secretions of mammals. Scientific information on human thelaziosis is still relatively limited, mainly for physicians and ophthalmologists. Indeed, the literature is full of misleading information on the transmiss...
journal_title：Parasites & vectors
pub_type： 杂志文章
doi：10.1186/s13071-015-0881-7
更新日期：2015-05-14 00:00:00
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journal_title：Parasites & vectors
pub_type： 杂志文章
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更新日期：2019-01-14 00:00:00
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journal_title：Parasites & vectors
pub_type： 杂志文章
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更新日期：2019-08-13 00:00:00
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journal_title：Parasites & vectors
pub_type： 杂志文章
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更新日期：2020-10-07 00:00:00
abstract：BACKGROUND:Ixodes ricinus is the most common tick species in Europe and the main vector for Borrelia burgdorferi (sensu lato) and tick-borne encephalitis virus (TBEV). It is involved also in the transmission of Borrelia miyamotoi, a relapsing fever spirochete that causes health disorders in humans. Little is known rega...
journal_title：Parasites & vectors
pub_type： 杂志文章
doi：10.1186/s13071-020-3969-7
更新日期：2020-02-27 00:00:00
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journal_title：Parasites & vectors
pub_type： 杂志文章
doi：10.1186/s13071-020-3929-2
更新日期：2020-02-11 00:00:00
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journal_title：Parasites & vectors
pub_type： 杂志文章
doi：10.1186/1756-3305-7-117
更新日期：2014-03-24 00:00:00
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journal_title：Parasites & vectors
pub_type： 杂志文章
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更新日期：2014-02-11 00:00:00
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journal_title：Parasites & vectors
pub_type： 杂志文章
doi：10.1186/s13071-020-04318-5
更新日期：2020-09-10 00:00:00
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journal_title：Parasites & vectors
pub_type： 杂志文章
doi：10.1186/s13071-015-0948-5
更新日期：2015-06-18 00:00:00
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journal_title：Parasites & vectors
pub_type： 杂志文章
doi：10.1186/s13071-019-3611-8
更新日期：2019-09-16 00:00:00
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journal_title：Parasites & vectors
pub_type： 杂志文章
doi：10.1186/1756-3305-7-372
更新日期：2014-08-15 00:00:00
abstract：BACKGROUND:The prevalence of bovine babesiosis caused by Babesia divergens has been declining during the past decades in northeastern Hungary, and no cases have been observed since 2008. Infections of cattle with B. major and Theileria buffeli were hitherto reported in southern and western Europe. In other parts of the...
journal_title：Parasites & vectors
pub_type： 杂志文章
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journal_title：Parasites & vectors
pub_type： 杂志文章
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更新日期：2011-02-26 00:00:00
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journal_title：Parasites & vectors
pub_type： 杂志文章,评审
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更新日期：2020-07-29 00:00:00
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journal_title：Parasites & vectors
pub_type： 杂志文章
doi：10.1186/s13071-020-3974-x
更新日期：2020-03-12 00:00:00
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journal_title：Parasites & vectors
pub_type： 信件
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更新日期：2020-11-10 00:00:00
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journal_title：Parasites & vectors
pub_type： 杂志文章
doi：10.1186/s13071-017-2556-z
更新日期：2017-12-27 00:00:00
abstract：BACKGROUND:Malaria vector control in Africa relies on insecticides targeting adult mosquito vectors via insecticide treated nets or indoor residual spraying. Despite the proven efficacy of these strategies, the emergence and rapid rise in insecticide resistance in malaria vectors raises many concerns about their sustai...
journal_title：Parasites & vectors
pub_type： 杂志文章
doi：10.1186/s13071-016-1354-3
更新日期：2016-02-05 00:00:00
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journal_title：Parasites & vectors
pub_type： 杂志文章
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更新日期：2018-06-19 00:00:00
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journal_title：Parasites & vectors
pub_type： 杂志文章
doi：10.1186/s13071-015-0756-y
更新日期：2015-03-23 00:00:00
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journal_title：Parasites & vectors
pub_type： 杂志文章
doi：10.1186/s13071-014-0608-1
更新日期：2015-01-06 00:00:00
abstract：BACKGROUND:Different species of apicomplexan protozoans of the genera Hepatozoon and Cytauxzoon can infect domestic cats, but their epidemiology and clinical relevance are not fully understood. The aim of this study was to assess the molecular prevalence of Hepatozoon spp. and Cytauxzoon spp. and to identify associated...
journal_title：Parasites & vectors
pub_type： 杂志文章
doi：10.1186/s13071-017-2056-1
更新日期：2017-03-13 00:00:00
