Abstract：
BACKGROUND:Fluralaner is a novel systemic ectoparasiticide for dogs and cats providing immediate and persistent flea- and tick-control after a single topical dose. Prescribing directions recommend waiting 72 h following topical administration before immersing dogs in water. The objective of this study was to determine whether water immersion immediately prior to treatment or earlier than 72 h post-treatment reduced subsequent treatment efficacy. METHODS:Forty (n = 40) dogs were blocked on tick carrying capacity into 5 experimental groups and all but one of the groups (untreated control) were treated topically with fluralaner (Bravecto® Spot-On Solution, Merck Animal Health, Madison, NJ, USA) at the commercial dose. Three of the four remaining groups were immersed in 38-40 °C water for a 5 min bath - either 1 h before treatment; 12 h after treatment; or 24 h after treatment. Seven days after treatment all dogs were challenged with 50 Rhipicephalus sanguineus (sensu lato) ticks and after 24 h attached ticks were counted and removed. RESULTS:Efficacies (compared to the untreated control group) were: 99.3% for no water immersion; 99.6% for immersion 1 h before treatment; 99.3% for immersion 12 h after treatment; and, 100% for immersion 24 h after treatment. CONCLUSIONS:Water immersion of dogs around the time of topical fluralaner administration did not reduce subsequent systemic acaricidal efficacy.
journal_name
Parasit Vectorsjournal_title
Parasites & vectorsauthors
Dongus H,Meyer L,Armstrong Rdoi
10.1186/s13071-017-2389-9subject
Has Abstractpub_date
2017-09-25 00:00:00pages
441issue
1issn
1756-3305pii
10.1186/s13071-017-2389-9journal_volume
10pub_type
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