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Clinical relevance of aortic calcification in urolithiasis patients.

Abstract：

BACKGROUND:The aim of the present study is to investigate the clinical relevance of aortic calcification in urolithiasis patients. METHODS:Between January 2010 and September 2014, 1221 patients with urolithiasis were treated in Oyokyo Kidney Research Institute and Hirosaki University Hospital. Among these, 287 patients (Stone group) on whom adequate data were available were included in this retrospective study. We also selected 148 subjects with early stage (pT1N0M0) renal cell carcinoma from 607 renal cell carcinoma patients who underwent radical nephrectomy at Hirosaki University Hospital (Non-stone group) as control subjects. Validity of the Non-stone group was evaluated by comparison with pair-matched 296 volunteers from 1166 subjects who participated in the Iwaki Health Promotion Project in 2014. Thereafter, age, body mass index, aortic calcification index (ACI), renal function, serum uric acid concentrations, and comorbidities (diabetes, hypertension, or cardiovascular disease) were compared between the Non-stone and Stone groups. Independent factors for higher ACI and impaired renal function were assessed using multivariate logistic regression analysis. RESULTS:We confirmed relevance of Non-stone group patients as a control subject by comparing the pair-matched community-dwelling volunteers. Backgrounds of patients between the Non-stone and Stone groups were not significantly different except for the presence of hypertension in the Stone group. ACI was not significantly high in the Stone group compared with the Non-stone group. However, age-adjusted ACI was greater in the Stone group than the Non-stone group. Among urolithiasis patients, ACI was significantly higher in uric acid containing stone patients. The number of patients with stage 3B chronic kidney disease (CKD) was significantly higher in the Stone group than in the Non-stone group (12% vs. 4%, P = 0.008). Multivariate logistic regression analysis showed higher aortic calcification index (>13%), and being a stone former were independent factors for stage 3B CKD at the time of diagnosis. CONCLUSION:Aortic calcification and being a stone former had harmful influence on renal function. This study was registered as a clinical trial: UMIN: UMIN000022962.

journal_name

BMC Urol

journal_title

BMC urology

authors

Tanaka T,Hatakeyama S,Yamamoto H,Narita T,Hamano I,Matsumoto T,Soma O,Tobisawa Y,Yoneyama T,Yoneyama T,Hashimoto Y,Koie T,Takahashi I,Nakaji S,Terayama Y,Funyu T,Ohyama C

doi

10.1186/s12894-017-0218-2

subject

Has Abstract

pub_date

2017-04-04 00:00:00

pages

issue

issn

1471-2490

pii

10.1186/s12894-017-0218-2

journal_volume

pub_type

临床试验,杂志文章

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Clinical relevance of aortic calcification in urolithiasis patients.